There is multisystem involvement in systemic lupus erythematosus
There are three different dematologic manifestations of lupus.
In chronic cutaneous lupus (discoid lupus) the most common dermatological manifestation is skin lesions that resemble coins in shape without systemic complaints.
With acute systemic lupus the classic and most familiar skin manifestation is a cutaneous lesion consisting of a butterfly shaped rash across the bridge of the nose and over the cheek. This is seen in about 50% of the patients.
Sunlight or artificial ultraviolet light can cause a severe flare up of disease and people with lupus must use sunscreen every day of there life regardless of there skin type or where they live.
Alopecia is common and the scalp becomes dry and scaly
problems include polyarthralgia, diffuse swelling by joints, Arthritis in 90% of patients
problems include tachypnea and cough suggesting restrictive lung disease, pleurisy, dysrhythmias resulting from fibrosis of the SA and AV nodes (advanced stages of Lupus),
include lupus nephritis in 40-85% of pts. Aggressive tx of this disease includes corticosteroids, cytotoxic agents, and immunosuppressive agents
problems include seizures, peripheral neuropathies, cognitive and psychiatric disorders (depression and psychosis)
abdom pain, diarrhea, Dysphagia, N/V
includes the formation of antibodies against blood cells. Anemia, leukopenia and thrombocytopenia are often present in SLE. Antiphosholipid syndrome is common (hypercoagulability associated with high blood levels of IgG antibodies against phospholipids, which are major component of cell membranes)
- Infection: SLE patients are at a high risk for developing infections because of defects in the ability to phagocytize invading bacteria, deficiencies in production of antibodies and the immunosuppressive effect of many ant-iinflammatory drugs they routinely take. Body is attacking itself causing ALL these problems.
- Malar rash-butterlfly