2) Which of the following is not a common component of biomolecules?
A) Carbon
B) Oxygen
C) Hydrogen
D) Chlorine
E) Nitrogen
D)
5) Which of the following is not a role played by carbohydrates in living cells?
A) Energy source
B) Structural support
C) Intercellular communication
D) Both A and B are correct
E) All are roles played by carbohydrates in living cells
E)
Which of the following is not a waste product of living organisms
A) Urea
B) Ammonia
C) Carbon dioxide
D) Glycine
E) Water
D)
Biochemistry is defined as
A) The study of the molecular basis of life
B) The study of organic compounds in living organisms
C) The study of life processes
D) The study of living compounds
E) The study of living organisms
A)
One of the principal methods that organisms use to obtain energy from chemical bonds is by ___________.
A) Dehydration reactions
B) Oxidation/reduction reactions
C) Substitution reactions
D) Hydration reactions
E) Addition reactions
B)
The following is an example of which reaction class?
CH3Br + HSCH2CH(NH2)COOH CH3SCH2CH(NH2)COOH + Br- + H+
A) Isomerization
B) Elimination
C) Addition
D) Oxidation/Reduction
E) Substitution
E)
The following is an example of which reaction class
HOOCCH=CHCOOH + H2O HOOCCH2CH(OH)COOH
A) Isomerization
B) Substitution
C) Elimination
D) Addition
E) Oxidation/Reduction
D)
The following is an example of which reaction class?
CH3CH2OH CH3CHO + H2O
A) Oxidation/Reduction
B) Addition
C) Substitution
D) Elimination
E) Isomerization
A)
The following molecule is an example of which single class of compounds?
CH3CH2CH(NH2)COOH
A) Ester
B) Acid
C) Amino acid
D) Amine
E) Alcohol
C)
he following molecule is an example of which class of compounds?
CH3CH2CH2COOCH2CH3
A) Ester
B) Acid
C) Aldehyde
D) Hydrocarbon
E) Ether
A)
The following molecule is an example of which class of compounds?
CH3CH2CH2COOH
A) Acid
B) Aldehyde
C) Alcohol
D) Ketone
E) Hydrocarbon
A)
Which of the following amino acids contain a hydrophobic side chain
Leucine
Arginine
Glutamine
Glutamic acid
Aspartic acid
A
Which of the following small molecules do not form biopolymers
Amino acids
Sugars
Fatty acids
Nucleotides
C and D
C
Choose the amino acid that can function as a neurotransmitter
Glutamic acid
Alanine
Tyrosine
Lysine
Cysteine
A
Which of the following is not characteristic of an autopoietic system?
A) Autonomous
B) Intelligent
C) Self-maintaining
D) Self-organizing
E) B and D
B)
Which of the following is not a core principle of systems biology?
A) Robustness
B) Redundancy
C) Emergence
D) Modularity
E) Limit of resolution
E)
The field of study associated with the investigation of gene expression patterns is called:
A) Synomics
B) Proteomics
C) Functional genomics
D) Genomics
E) Bioinformatics
C)
Which of the following is not an example of a macromolecule?
A) Protein
B) Amino acid
C) Nucleic acid
D) Enzyme
E) Polysaccharide
B)
Which of the following is not considered a class of small biomolecule?
A) Nucleotide
B) Fatty acid
C) Sugar
D) Amino acid
E) Nucleic Acid
E)
The majority of Earth’s species belong to which of the following classifications
Eukaryotes
Prokaryotes
Viruses
Mammals
Archea
B
The conversion of earths atmosphere from anerobic to aerobic was due to the development of _________________ by cyanobacteria
Photosynthesis
Metabolism
Chemosynthesis
Oxidation of iron
Fixation of nitrogen as cyanide
A
The largest mass extinction also known as the great dying was called the
Cenezoic extinction
Permian extinction
Mesozoic event
Great ice age
The great plague
B
During exocytosis membrane-bound vesicles migrate from the Golgi apparatus to the __________.
A) Smooth endoplasmic reticulum
B) Lysosome
C) Cell wall
D) Plasma membrane
E) More than one answer is correct
D)
Structural features that make phospholipids suited for their biological role are:
A) A hydrophilic head group
B) Branched carbon chains
C) A hydrophobic group
D) A and C are correct
E) None of the above are true
D)
Which of the following types of molecules is not hydrophilic
Sodium chloride
Glucose
Amino acids
Fats
A and B
D
The basic structure of biological membranes is provided by what class of compounds?
A) Lipids
B) Steroids
C) Proteins
D) Peptidoglycans
E) Carbohydrates
A)
Which of the following statements is not true of the endoplasmic reticulum?
A) Rough ER ribosomes are responsible for biotransformation.
B) It exists in two forms: rough and smooth
C) Smooth ER is responsible for lipid synthesis
D) Rough ER is responsible for protein synthesis
E) It often constitutes more than half of the cell’s total membrane
A)
12) Which of the following statements is not true of the Golgi apparatus?
A) It has two faces
B) The analogous plant structure is referred to as a dictyosome
C) The cisterna or forming face usually projects toward the ER
D) It is usually located near the plasma membrane
E) It is involved in the packaging and secretion of cell products
D)
Acid hydrolases are found in ___________.
A) Lysosomes
B) Smooth ER
C) Dictyosomes
D) Golgi Apparatus
E) Ribosomes
A)
Biological machines are derived from which class of compounds
Fats
Proteins
Carbohydrates
Ribosomes
B and C
B
Which of the following organelles is involved in aerobic metabolism?
A) Glyoxysomes
B) Ribosomes
C) Mitochondria
D) Peroxisomes
E) Lysosomes
C)
Respiratory assemblies are responsible for the synthesis of ___________.
A) Hydrogen peroxide
B) NADH
C) ATP
D) GTP
E) ADP
C)
Which of the following statements is not true of the mitochondrial matrix?
A) It contains circular DNA molecules
B) It contains enzymes responsible for nucleotide metabolism
C) It has a high concentration of enzymes and ions
D) It has a gel-like consistency
E) It contains all of the necessary compounds for protein synthesis
B)
The excluded volume of a cell varies between _____ and ______%.
A) 5-10
B) 40-50
C) 20-40
D) 10-20
E) 0-5
C)
Plastids are plant structures similar to what organelle found in animals?
A) Ribosomes
B) Leucoplasts
C) Golgi apparatus
D) Peroixsomes
E) None of the above is correct
E)
The stroma of plastids is analogous to what structure of mitochondria?
A) Matrix
B) Grana
C) Outer membrane
D) Inner membrane
E) Cisternal space
A)
Biotransformation is defined as:
A) Transformation of food molecules to ATP
B) The preparation of water-insoluble substances for excretion
C) Oxidation of organic molecules
D) Reactions occuring within a living system
E) Conversion of harmless compounds to toxins
B)
In place of a nucleus a prokaryotic cell has a __________.
A) Nucleoid
B) Mesosome
C) Reticulosome
D) Centrosome
E) Nucleosome
A)
Which of the following is not a membrane protein?
A) Receptors
B) Motor proteins
C) Channel protein
D) Integral proteins
E) Carrier protein
B)
Examples of eukaryotic signal molecules are:
A) Neurotransmitters
B) Hormones
C) Cytokines
D) Both A and B are correct
E) All of the above are correct
E)
Which of the following is not a phase of the information processing mechanism?
A) Reception
B) Transduction
C) Response
D) Transformation
E) Both A and C are correct
D)
34) Which of the following is not a component of the endomembrane system?
A) Lysosomes
B) Ribosomes
C) Endoplasmic reticulum
D) Golgi apparatus
E) Plasma membrane
B)
The carbohydrate coat of a cell is called the:
A) Extracellular matrix
B) Glycocalyx
C) Cell cortex
D) Fibroblast
E) Both A and C are correct
B)
The perinuclear space is:
A) The space between the nucleus and the cytoplasm
B) The space between the membranes of the nuclear envelope
C) The space between the nucleus and the nucleous
D) The space between DNA and histones
E) Both A and B are correct
B)
Which of the following organelles are involved in autophagy?
A) Mitochondria
B) Lysosomes
C) Chloroplasts
D) Golgi apparatus
E) Both B and C are correct
B)
Which of the following molecules is not an example of a type of eukaryotic signal molecule
type?
Neurotransmitters
Hormones
Cytokinins
Endotoxins
A and B
D
Of the 100 approximately trillion free living cells in the human body how many are actually human cells?
All of them
50 Trillion
90 Trillion
10 Trillion
80 Trillion
D
Analysis of the RNA of prokaryotes reveals that there are ______ distinct types of
prokaryotes.
One
Two
Three
Four
Five
B
Which of the following are microbiota
Bacteria
Fungi
Archea
A and B
A, B and C
E
The endocytotic cycle is
A means of remodeling plasma membrane
A form a signal transduction
Cycling of sodium and potassium ions through the cell membrane
Continuous recycling of membrane through endocytosis and exocytosis
A and D
A
A hydrogen bond is best defined as:
A) A weak electrostatic bond between hydrogen and oxygen or nitrogen
B) A relatively strong electrostatic bond between hydrogen and oxygen or nitrogen
C) A weak chemical bond between hydrogen and another element
D) A strong chemical bond between hydrogen and another element
E) A bond between two hydrogens
B)
Which of the following compounds is capable of hydrogen bonding with like molecules?
A) CH3CH2CH2CH2CH3
B) CH3CH2OCH2CH3
C) CH3NH2
D) HOCH2CH2OH
E) Both C and D are correct
E)
Which of the following is not a type of van der Waals force?
A) Induced dipole – induced dipole interactions
B) Chemical bonds
C) Dipole-induced dipole interactions
D) Hydrogen bonds
E) Dipole-dipole interactions
B)
Which of the following is not an example of noncovalent interactions between molecules?
A) Salt bridges
B) Chemical bonds
C) Ionic bonds
D) Hydrophobic interactions
E) Hydrogen bonds
B)
Which of the following factors is responsible for the fact that water is a liquid at room temperature?
A) Covalent O-H bonds
B) The molecular weight of water
C) Ionic bonds
D) Hydrogen bonds
E) Hydrophobic bonding between water molecules
D)
Which of the following properties of water promotes the relatively constant climate of earth?
A) High heat capacity
B) High surface tension
C) High heat of fusion
D) A, C, and D are all important
E) High heat of vaporization
D)
Which of the following compounds is amphipathic?
A) H2O
B) CH3CH2CH2CH2CH3
C) HOOCCOOH
D) CH3CH2CH2CH2COOH
E) Both A and D are correct
D)
Which of the following statements is true of weak acids dissolved in water?
A) The dissociation constant is a function of pH
B) They are completely ionized in water
C) They are partially ionized in water
D) The dissociation constant is a function of solute concentration
E) They are totally unionized in water
C)
What is the pH of a solution where the concentration of hydrogen ions is 2 x 10-5 molar?
A) 4.7
B) 5
C) 5.3
D) 2.5
E) 2
A)
Which of the following would not form a suitable buffer?
A) Bicarbonate/ carbonate
B) Acetic acid/ acetate
C) Carbonic acid/ bicarbonate
D) Phosphoric acid/ dihydrogen phosphate
E) Hydrochloric acid/ chloride
E)
The sodium acetate/acetic acid buffer is 0.1 molar in sodium acetate and 0.5 molar
in acetic acid. What is the concentration of the buffer?
A) 0.1 molar
B) 0.5 molar
C) 0.4 molar
D) Either A or B depending on whether acid or base is being added to the buffer.
E) 0.6 molar
E)
The pH of a solution that is 0.25 molar in acetic acid and 0.1 molar in sodium acetate is 4.36. What is the pKa of acetic acid?
A) 5.76
B) 4.36
C) 3.76
D) 4.76
E) 7.76
D)
The most important buffer in blood is __________.
A) Phosphate buffer
B) Lactate buffer
C) Protein buffer
D) Carbonate/bicarbonate buffer
E) Tartrate buffer
D)
When an individual breathes very rapidly, large amounts of carbon dioxide are exhaled. What effect does this have on blood pH?
A) First alkalosis then rebounding acidosos
B) Alkalosis
C) No change
D) Acidosis
E) First acidosis then rebounding alkalosis
B)
Salt bridges in proteins are an example of _________.
A) London dispersion forces
B) Ionic interactions
C) Hydrogen bonds
D) van der Waals forces
E) Hydrophobic interactions
B)
What is the osmorlarity of a solution that is 0.25 molar in trisodium phosphate?
A) 0.25 osmolar
B) 0.5 osmolar
C) 0.75 osmolar
D) 1.0 osmolar
E) None of the above are correct
D)
Red blood cells are isotonic to a solution that is 0.9% sodium chloride. These same cells are _______________ to a solution that is 0.9% sodium sulfate.
A) Nontonic
B) Hypertonic
C) Isotonic
D) Tonic
E) Hypotonic
E)
Which of the following molecules would have a dipole moment?
A) I2
B) CCl4
C) CHCl3
D) H2
E) CH3CH3
C)
Which of the following molecules would form a micelle?
A) CH3COOH
B) CH3CH2CH2CH2CH2CH3
C) NaCl
D) H3PO4
E) CH3(CH2)10COO- Na +
E)
Which of the following molecules are weak acids?
A) HCl
B) CO3-2
C) HNO3
D) HCO3-
E) Both B and D
D)
Which of the following ions would have the largest hydration sphere?
A) Na+
B) K+
C) All would have the same size hydration sphere
D) Li+
E) Cs+
D)
Hydration is best defined as
A) Covalent interaction between water and a solute
B) Noncovalent interaction between water and a solute
C) Salt formation in water
D) Ionization of a base to produce hydroxide ions
E) Both C and D are correct
B)
The noncovalent interaction between an amide and an alcohol would be which of the following?
A) Salt bridges
B) Hydrophobic
C) Hydrogen bonding
D) Both A and C are correct
E) All of the above are true
C)
Crenation would result when cells are placed in a ___________ solution.
A) Isotonic
B) Hypotonic
C) Nontonic
D) Nonaqueous solvent
E) Hypertonic
E)
Which of the following is not an important noncovalent interaction of living organisms
Ionic interactions
Van der Waals interactions
Hydrogen bonds
Carbon hydrogen bonds
All are important
D
Which of the following molecules would have unusually high heat capacities?
A) Ammonia
B) Methane
C) Methyl alcohol
D) Benzene
E) Both A and C are correct
E)
The hybridization of the water molecule is:
A) Sp2
B) Sp3
C) Unhybridized
D) Sp
E) Planar
B)
The strongest type of non covalent force is
Dipole-Dipole
Dipole-Induced Dipole
Induced Dipole – Induced Dipole
London dispersion forces
Hydrogen bonds
E
Which of the following ions would have the strongest tendency to form an ion pair with carboxylate groups the surface of a protein?
A) All have the same tendency
B) Potassium
C) Sodium
D) These ions do not associate with proteins
E) Lithium
B)
Which of the following species would form a buffer with HPO4-2?
A) H3PO4
B) H2PO4-1
C) CO3-2
D) All would form buffers with HPO4-2
E) Both A and B
B)
Water can form how many hydrogen bonds
One
Two
Three
Four
Five
D
Which of the following solutions will be isotonic with 3M sucrose?
A) 3M NaCl
B) 1 M Sodium sulfate
C) 1.5 M Proline
D) 2 M Sodium chloride
E) 1 M Magnesium sulfate
B)
Which of the following molecules is hydrophobic?
A) Sodium chloride
B) Ethyl alcohol
C) Hexane
D) Sucrose
E) Ammonia
C)
In biological systems buffers usually contain an excess of __________.
A) It would depend on the system
B) The two components of the buffer are present in equal amounts
C) Weak acid
D) Weak base
E) None are correct
D)
The tendency of nonpolar molecules to aggregate in a water medium is called ________.
A) Hydrophillic effect
B) Amphiatic
C) Micellular effect
D) Crenation
E) Hydrophobic effect
E)
The high heat of fusion of water is due to its _______________.
A) High heat of vaporization
B) A, C, and D are all important
C) High heat capacity
D) Hydrogen bonding
E) High surface tension
D)
Which of the following is not a role of water in the body
Nutrient absorption
Nutrient transport
Waste product excretion
Temperature regulation
All are roles of water
E
Which of the following species can form a buffer system
Hydrochloric acid / Acetic acid
Acetic acid / Sodium chloride
Acetic acid / Ammonium chloride
Acetic acid/ Sodium acetate
Phosphoric acid / Sodium phosphate
D
Which of the following are unusual properties of water that suit it to be the matrix
of life
Tetrahedral hybridization
Presence of oxygen
Thermal properties
Solvent characteristics
C and D
E
What percentage of the worlds water is drinkable
100%
60%
3%
1%
97%
C
The immediate effect of deforestation is
Drought
Erosion
Formation of grasslands
Formation of deserts
Increase in the water table
B
Which of the following is not an effect of hydrogen bonding on the
physical properties of water
Increased boiling point
Increased heat of fusion
Increased melting point
Increased heat of vaporization
All are effects of hydrogen bonding
E
The course of chemical reactions is determined by three factors. These are enthalpy, entropy and
A) Heat of reaction
B) Free energy
C) States of matter
D) Bond energy
E) Both A and B are correct
B)
Which of the following statements is true of an open system
A) There is an exchange of energy only with the surroundings
B) There is an exchange of matter only with the surroundings
C) There is an exchange of both matter and energy with the surroundings
D) In an open system either matter or energy, but not both may be exchanged with the surroundings
E) Energy flows only into the system: matter flows out of the system.
C)
Which of the following statements is true of a closed system?
A) There is an exchange of energy only with the surroundings
B) There is an exchange of matter only with the surroundings
C) There is an exchange of both matter and energy with the surroundings
D) In an closed system either matter or energy, but not both may be exchanged with the surroundings
E) Energy flows only into the system: matter flows out of the system.
A)
Which of the following thermodynamic properties is a state function?
A) Work
B) Heat
C) Enthalpy
D) Entropy
E) Both C and D are correct
E)
The first law of thermodynamics is described by which of the following equations?
A) ΔE = Q+W
B) ΔQ = E-W
C) ΔW = Q-W
D) Both B and C are correct
E) All of the above are correct.
A)
Which of the following statements is not true of a spontaneous process?
A) The work value is negative
B) The enthalpy value is negative
C) The entropy value is negative
D) The enthalpy value is positive
E) The free energy value is positive
C)
Which of the following is not a standard condition for standard free energy?
A) 1 Atm pressure
B) Concentration of reactants = 1 molar
C) Concentration of products = 1 molar
D) 25 0C
E) pH = 7
E)
The ionization constant of acetic acid is 1x10-5. What is ΔGo for the reaction?
A) 1624 cal/mol
B) 6500 cal/mol
C) 6000 cal/mol
D) –6500 cal/mol
E) 3250 cal/mol
B)
Under standard conditions is the ionization of a carboxylic acid spontaneous or not? A typical carboxylic acid has a pKa of 4.
A) It is not spontaneous
B) Not enough information is provided
C) It is spontaneous
A)
When water and hydrophobic molecules are mixed all of the following are true except:
A) The hydrophobic molecules aggregate
B) The free energy of dissolving molecules is unfavorable
C) -TΔS becomes negative
D) Water’s hydrogen-bonded interactions are disrupted
E) All of the above are true.
E)
The oxidation of food molecules to form CO2 and H2O is a(n) _______ process.
A) Exergonic
B) Lithotropic
C) Endergonic
D) Isothermic
E) Spontaneous
A)
The law of the conservation of energy states that
A) There are three laws of thermodynamics
B) The work that can be performed by a system is a constant
C) The energy of a system’s surroundings is constant
D) The total energy of the universe is constant
E) Entropy of a system increases
D)
Which of the following is a low quality energy source
Electromagnetic radiation
Heat
Electrical Energy
Chemical Energy
B and C
B
Which of the following statements regarding free energy changes is true?
A) At equilibrium ΔG0 = O
B) For the reaction to be spontaneous ΔGo must be positive
C) Free energy is a state function
D) Both A and C are true
E) All of the above are true
D)
Which of the following compounds would liberate the most free energy on hydrolysis?
A) PPi
B) Phosphoenolpyruvate
C) GTP
D) ATP
E) ADP
B)
Which of the following thermodynamic properties is the most useful criterion of spontaneity?
A) Change in temperature
B) Entropy
C) Enthalpy
D) Free energy
E) Standard free energy
D)
For a reaction to be spontaneous which of the following statements must be true?
ΔSuniv= O
ΔSuniv = positive
ΔSiniv = negative
A or B
Entropy has no effect on the spontaneity of a process
B
Which of the following processes are driven by the hydrolysis of ATP?
A) Biosynthesis of biomolecules
B) Active transport of substances across membranes
C) Mechanical work such as muscle contraction
D) Both A and B are correct
E) All of the above are correct
E)
The study of reaction rates is called ___________.
A) Kinetics
B) Mechanics
C) Reactions
D) Entropics
E) Thermodynamics
A)
Which of the following is described by the first law of thermodynamics
Enthalpy
Entropy
Free energy
A and B
A, B and C
A
Which of the following is described by the second law of thermodynamics
Enthalpy
Entropy
Free energy
A and B
A, B and C
B
What type of bond is being cleaved during the conversion of ATP to ADP?
A) Amide
B) Anhydride
C) Ether
D) Hydrogen
E) Ester
B)
The tendency of ATP to undergo hydrolysis is called __________.
A) Free energy of hydrolysis
B) Cleavage rate
C) Phosphoryl group transfer potential
D) High energy bond potential
E) None of the above is correct
C)
The products of the hydrolysis of ATP are more stable than ATP itself. This circumstance is due to __________.
A) pH effects
B) Relief of charge-charge repulsions
C) Resonance stabilization of the products
D) Relief of steric strain
E) Both B and C are correct
E)
A living organism is what type of thermodynamic system?
A) Closed
B) Open
C) A system at equilibrium
D) A system with negative entropy
E) Both C and D are correct
B)
Which of the following thermodynamic properties is pathway dependent?
A) Free energy
B) Entropy
C) Enthalpy
D) Work
E) Both B and C are correct
D)
The rate of a reaction can be determined from which of the following?
A) Free energy
B) Enthalpy
C) Entropy
D) All of the above are correct
E) None of the above are correct.
E)
Systems far from equilibrium are referred to as _________ systems.
A) Spontaneous
B) Heterotropic
C) Entropic
D) Dissipative
E) Critical
D)
An organism at equilbrium is said to be __________.
A) Organized
B) Dissipative
C) At rest
D) Dormant
E) Dead
E)
The following statement is made by which law of thermodynamics?
“At absolute zero the disorder of a perfect crystal approaches zero”.
First Law
Second Law
Third Law
A and B
All make this statement
C
A measure of a system’s internal energy is
Enthalpy
Entropy
Free energy
Work
Heat
A
In living organisms where does the increase in entropy takes place?
Cell
Surroundings
Either A or B
Entropy does not change
Entropy does not apply to living things
B
How many molecules of oxygen are required to completely oxidize one mole of stearic acid ( C17H35COOH)?
A) 53
B) 9
C) 45
D) 18
E) 34
A)
Given the following ΔH values calculate the ΔH for the complete combustion of stearic acid.
ΔH (kal/mol) Compound
-211.4 C17H35COOΗ
0 Oxygen
-94 Carbon dioxide
-68.4 Water
A) 3071.8 kal
B) –49 kal
C) 0 kal
D) –2711.8 kal
E) –2096.2 kal
D)
Magnesium ion (Mg++) forms complexes with ATP. What would happen to the stability of ATP if the magnesium was removed?
A) The ATP would be more stable
B) The ATP would be less stable
C) Either A or B is correct
D) There would be no change in stability
E) The effect on stability would depend on specific conditions
B)
Choose the molecule with the highest phosphate transfer potential.
Phosphoenolpyruvate
ATP
PPi
Glucose-1-phosphate
Carbamoyl phosphate
A
Biogeochemical cycles are pathways driven by which of the following?
Nuclear
Solar
Geothermal energy
Tectonic movements
B and C
E
Which of the following moves through a system in a biogeochemical cycle?
Chemical compounds
Heat
Light
Energy
All of the above
E
In classical thermodynamics which of the following is true?
All systems are at or near equilibrium
All materials are at low concentration
The system is far from equilibrium
The systems are always open
A and B
E
A Benard cell is an example of
A classical thermodynamic system
A system at equilibrium
A dissipative system
A system at uniform temperature
B and C
C
The evolution of living organisms is driven by
Size of the energy gradient to be dissipated
First law of thermodynamics
Second law of thermodynamics
Attainment of equilibrium
A and C
E
A process is spontaneous when
ΔG0 = 0
ΔG0 > 0
ΔG0 < 0
Energy is absorbed
Entropy is negative
C
Which of the following is a function of proteins?
A) Defense
B) Metabolic regulation
C) Transport
D) Catalysis
E) All of the above are correct
E)
The term protein refers to amino acid polymers with greater than ________amino acids.
50
Which of the following is a nonstandard amino acid?
A) 5-Hydroxyproline
B) Alanine
C) Glycine
D) Valine
E) Cysteine
A)
Which of the following is a heterocyclic amino acid?
A) Cystine
B) Alanine
C) Valine
D) Tyrosine
E) Proline
E)
Which of the following is not a class of amino acid?
A) Basic
B) Polar and neutral
C) Asymmetric
D) Acidic
E) Nonpolar and neutral
C)
Which of the following amino acids lacks a center of asymmetry?
A) Alanine
B) Glycine
C) Valine
D) Aspartic acid
E) Isoleucine
B)
Given the following pKa’s the isoelectric point of serine is ________.
pK1 = 2.21 pK2 = 9.15
A) 5.68
B) 6.62
C) 9.15
D) 11.36
E) 2.21
A)
The amino acid sequence of a polypeptide is referred to as ________structure.
A) Primary
B) Peptide
C) Tertiary
D) Quaternary
E) Secondary
A)
The overall three-dimensional structure of a polypeptide is referred to as _________ structure.
A) Primary
B) Quaternary
C) Secondary
D) Tertiary
E) Peptide
D)
Invariant amino acids in a protein are presumed:
A) To be unimportant in the structure and function of the protein
B) Always to occur at the end of the amino acid sequence of an enzyme
C) To be part of the prosthetic group.
D) To be essential to the structure and function of the protein
E) Always to occur at the beginning of the amino acid sequence of an enzyme
D)
β-pleated sheets are associated with what level of protein structure?
A) Tertiary
B) Primary
C) Superquaternary
D) Quaternary
E) Secondary
E)
Which of the following amino acids would foster an α-helix?
A) Alanine
B) Serine
C) Proline
D) Glycine
E) Tyrosine
A)
The Greek key is associated with which of the following?
A) Salt bridges
B) α-helix
C) Disulfide bridges
D) Antiparallel β-pleated sheets
E) Parallel β-pleated sheets
D)
Which of the following interactions do not stabilize tertiary structure?
A) Hydrophobic interactions
B) Electrostatic interactions
C) Hydrogen bonds
D) Covalent bonds
E) None of the above
E)
Detergents denature proteins by disrupting which of the following?
A) Hydrogen bonds
B) Disulfide bridges
C) Hydrophobic interactions
D) Salt bridges
E) Both A and B are correct
C)
Fibrous proteins typically have large amounts of:
A) α-Helix
B) β-Pleated sheets
C) Disulfide bridges
D) Salt bridges
E) Both A and B are correct
E)
The identity and arrangement of amino acids on the surface of a globular protein are important because they may:
A) Interact to form specific binding cavities
B) Stabilize the tertiary structure of the protein
C) Bind regulatory molecules
D) Both A and C are correct
E) All of the above are correct
E)
Which of the following statements regarding cooperative binding is true?
A) Two or more proteins aid the binding of a ligand.
B) The folding of part of a protein aids in the folding of the remainder of the protein
C) The binding of one ligand aids the binding of a second ligand
D) The binding of a cofactor to a protein aids in the binding of a ligand.
E) All proteins engage in cooperative binding
C)
Which of the following statements is true of the Bohr effect?
A) Oxygen is delivered to cells in proportion to their needs
B) Binding of protons to hemoglobin molecules facilitates the binding of oxygen
C) Metabolic waste products bond to oxyhemoglobin
D) A and B are both true
E) All of the above are true
A)
A polypeptide has a high pI value. Which of the following amino acids are likely to be present?
A) Arginine
B) Aspartic acid
C) Serine
D) Glycine
E) Valine
A)
Structural proteins “freeze” large amounts of water. Which of the following interactions is not likely to be involved in the binding of water?
A) Salt bridges
B) Hydrogen bonding
C) Hydrophilic interactions
D) Disulfide bridges
E) Both C and D are correct.
D)
Why is the peptide bond stronger than the ester bond?
A) Greater electronegativity of oxygen
B) Increased basicity of nitrogen
C) Greater electronegativity of nitrogen
D) Resonance stabilization of the amide bond
E) Size of the nitrogen atom compared to the oxygen atom
D)
Which of the following amino acids would be classified as a nonstandard amino acid
Tyrosine
Lysine
Cystine
Glycine
Arginine
C
Given that pK1 = 2.35 and pK2 = 9.69 for alanine. What is its isoelectric point
9.69
2.34
6.02
12.03
7.00
C
When not at the terminal of a protein which of the following amino acids cannot contribute to the PI of a protein?
Arginine
Lysine
Cysteine
Tyrosine
Alanine
E
When part of a polypeptide chain other than the N-terminus, which of the following amino acids can form a aldimines?
Glycine
Alanine
Proline
Histidine
Lysine
E
Collagen is classified as which of the following types of protein?
Enzyme
Structural
Movement
Defense
Regulatory
B
A prosthetic group is a :
A) Repair enzyme
B) Group that generates the native form of a protein
C) Group other than an amino acid that is part of a protein
D) Disulfide link
E) Group that reduces enzyme activity
C)
The major component of the dry weight of cells is _______.
A) Protein
B) Minerals
C) Carbohydrate
D) The major component will vary from organism to organism
E) Fats
A)
The total number of proteins that can be produced from any 10 amino acids is?
A) 10^10
B) 20^10
C) 10^20
D) 100
E) 200
B)
Schiff bases are also referred to as:
A) Aldimines
B) Amines
C) Carbinolamines
D) Amino acids
E) Both A and C are correct
A)
Which of the following amino acids would be found in a β-turn?
A) Alanine
B) Tyrosine
C) Proline
D) Phenylalanine
E) Lysine
C)
Which of the following is not a function of IUPs?
A) Translation
B) Cell proliferation
C) Transcription
D) Signal transduction
E) Oxygen transport
E)
The source of energy for motor proteins in addition to ATP is:
A) PEP
B) GTP
C) ADP
D) PPi
E) NAD+
B)
Keratin is classified as which of the following types of protein?
Enzyme
Structural
Movement
Defense
Regulatory
B
In which of the following mechanical properties does spider silk exceed all synthetic fibers?
A) Toughness
B) Tensile strength
C) Elasticity
D) Resilience
E) All of the above
E)
Which of the following is a hydrophobic amino acid?
A) Glycine
B) Serine
C) Lysine
D) Phenylalanine
E) Both C and D are hydrophobic
E)
A conjugated protein consists of a simple protein combined with a _________.
A) Apoprotein
B) Holoprotein
C) Prosthetic group
D) Answers B and C are correct
E) All of the above are correct
C)
Which of the following amino acids is not one of the twenty standard amino acids?
Glycine
Phenylalanine
Tyrosine
Cystine
Arginine
D
How many standard amino acids are there?
5
17
20
12
32
C
How many octapeptides containing only two amino acids are possible?
8
148
16
256
35
D
Amino acid polymers with a molecular weight between several thousand and several million Daltons are called
Dipeptides
Polypeptides
Proteins
Peptides
None of the above
C
Which of the following is not a function of proteins?
Structural materials
Catalyst
Metabolic regulation
Transport
All of the above are functions of proteins
E
Which of the following is a polar amino acid?
Phenylalanine
Tyrosine
Methionine
Tryptophan
Proline
B
The minimum amount of energy required to bring about a chemical reaction is called:
Activation energy
In contrast to inorganic catalysts, enzymes have an intricately shaped surface called the __________.
Active site