CBF2

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Cadence
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291000
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CBF2
Updated:
2014-12-08 05:01:09
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cell biology
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CBF2
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  1. For each of the following (21 – 23), pick the correct cellular location from the indicated list.
    A. inner membrane of mitochondria
    B. intermembrane space of mitochondria
    C. outer membrane of mitochondria
    D. matrix of mitochondria
    E. cytoplasm

    21. breakdown of glucose to pyruvate-
    E. cytoplasm
    (this multiple choice question has been scrambled)
  2. For each of the following (21 – 23), pick the correct cellular location from the indicated list.
    A. cytoplasm
    B. outer membrane of mitochondria
    C. matrix of mitochondria
    D. inner membrane of mitochondria
    E. intermembrane space of mitochondria

    22. enzymes of citric acid cycle -
    C. matrix of mitochondria
    (this multiple choice question has been scrambled)
  3. For each of the following (21 – 23), pick the correct cellular location from the indicated list.
    A. cytoplasm
    B. outer membrane of mitochondria
    C. matrix of mitochondria
    D. inner membrane of mitochondria
    E. intermembrane space of mitochondria

    23. Highest concentration of H+ ions in mitochondria -
    E. intermembrane space of mitochondria
    (this multiple choice question has been scrambled)
  4. 24. A nucleoside contains the following groups a. phosphate and ribose sugar
    b. phosphate and organic base
    c. ribose sugar and organic base
    d. ribose, phosphate, and organic base
    c. ribose sugar and organic base
  5. Tertiary and quaternary structures include a type of covalent bond called a ____________________, which is formed from the R groups of the AA _________________________.
    A. disulfide; cysteine
    B. dihydride; lysine
    C. disulfide; tyrosine
    D. dipolar; cysteine
    E. dihydride; serine
    A. disulfide; cysteine
    (this multiple choice question has been scrambled)
  6. Nucleic acids are formed by phosphodiester bonds between the ____________ group of one nucleotide and the ______________________________ group of the other nucleotide.
    A. 5’ phosphate; 5’phosphate
    B. organic base; 5’ phosphate
    C. 3’OH’; 3’OH
    D. 5’ OH; 3’ phosphate
    E. 3’ OH; 5’ phosphate
    E. 3’ OH; 5’ phosphate
    (this multiple choice question has been scrambled)
  7. In competitive inhibition of enzyme activity, the compound will bind
    A. anywhere on the enzyme, depending on the inhibitor.
    B. to a special binding site on the enzyme.
    C. to the active site of the enzyme.
    D. to the N-terminus of the enzyme.
    E. to the C-terminus of the enzyme
    C. to the active site of the enzyme.
    (this multiple choice question has been scrambled)
  8. What is the fate of the ATP produced in glycolysis?
    A. Used for the production of acetyl-CoA
    B. Goes to the mitochondria for used in oxidative phosphorylation.
    C. Not used for anything, must be turned into ADP so it can be used in glycolysis again.
    D. Used in coupled chemical reactions throughout the cell.
    D. Used in coupled chemical reactions throughout the cell.
    (this multiple choice question has been scrambled)

  9. 29. How many substrates are in the metabolic pathway shown above?
    A. 1
    B. 3
    C. 2
    D. 4
    B. 3
    (this multiple choice question has been scrambled)

  10. What is the likely mechanism by which this pathway is regulated?
    a. “A” compound concentration is regulated.
    b. “C” compound concentration is regulated.
    c. “D” compound acts as inhibitor of enzymes in the pathway.
    d. “A” compound acts as an allosteric activator of enzymes in the pathway.
    “A” compound acts as an allosteric activator of enzymes in the pathway.

  11. 21.  The final resting membrane potential in this cell is due to contributions from
    a. Na+K+ pump
    b. Ca2+ pump
    c.  K+ leak channels
    d.  Both a and c
    • a. Na+K+ pump
    • c.  K+ leak channels
    • d.  Both a and c

  12. The channel at “D” is located in the postsynaptic cell and is involved in signal transmission When opened, it causes depolarization of the membrane (but not necessarily an action potential).This channel is a _____________________ gated ___________ channel.
    A. voltage; Na+
    B. ligand; Na+
    C. voltage; K+
    D. ligand; Cl-
    B. ligand; Na+
    (this multiple choice question has been scrambled)

  13. The vesicles at “C” are regulated secretory vesicles filed with neurotransmitters.  Where were the neurotransmitter molecules concentrated in the vesicles?
    A.  transport vesicle
    B.  trans-Golgi
    C.  ER
    D.  cis-Golgi
    B.  trans-Golgi
    (this multiple choice question has been scrambled)

  14. These same vesicles “C” fuse to the plasma membrane of the presynaptic neuron due to increase of which ion in the cell?
    A.  H+
    B.  K+       
    C.  Na+         
    D. Ca2+         
    D. Ca2+
    (this multiple choice question has been scrambled)

  15. What signal sequences would be required for correct targeting of these neurotransmitter proteins to the regulated secretory vesicles at “C”?
    A.  ER signal and another “special signal”
    B.  ER signal sequence and KDEL
    C.  ER signal and mannose-6-phosphate
    D. none
    A.  ER signal and another “special signal”
    (this multiple choice question has been scrambled)

  16. The channel protein “B” ensures that the action potential doesn’t move backwards (towards the cell body).  This is a ___________________________ channel that when opened causes the inside of the membrane to become more ___________________.
    A. ligand gated K+, positive
    B. voltage gated Cl-, negative
    C. ligand gated Na+; positive
    D. voltage gated K+; negative
    D. voltage gated K+; negative
    (this multiple choice question has been scrambled)

  17. The channel at “A” is responsible for the action potential in this neuron.  The channel opens when the membrane potential becomes more ________________ and one of its transmembrane domains ________________________________.
    A. positive; changes conformation
    B.  positive; becomes phosphorylated
    C.  negative; becomes phosphorylated
    D.  negative; changes conformation
    A. positive; changes conformation
    (this multiple choice question has been scrambled)
  18. The structures of the mitochondria and chloroplasts offer a particular challenge to transferring proteins into these organelles.  What is this structural feature?
    A.  They both have double membranes.
    B.  They both have a membrane and outer carbohydrate wall.
    C.  They are both very large organelles.
    D.  They both have their own DNA and can replicate.
    A.  They both have double membranes.
    (this multiple choice question has been scrambled)
  19. Uptake of cholesterol in cells is an example of how small molecules are taken up by endocytosis.  In this process, what stimulates the cell to begin forming endocytotic vesicles?
    A. binding of the LDL particles to receptors in the membrane.
    B. binding of the cholesterol to the phospholipids in the plasma membrane.
    C. binding of the LDL particles to particular glycolipids in the membrane.
    D. insertion of the cholesterol into the phospholipids bilayer.
    A. binding of the LDL particles to receptors in the membrane.
    (this multiple choice question has been scrambled)
  20. Proteins can get through membranes by all of the following molecular mechanism except which one?
    A.  in vesicles
    B.  through transporter proteins
    C.  through protein translocators
    D.  through nuclear pores
    B.  through transporter proteins
    (this multiple choice question has been scrambled)
  21. Which of the following statements about the plasma membrane phospholipids is NOT TRUE?
    A.  A given phospholipid can be saturated or unsaturated but not both.
    B. The phospholipid lipids can easily move in each leaflet (side).
    C.  Carbohydrates can be attached to phospholipids.
    D.  The types of phospholipids vary in the plasma membrane.
    A.  A given phospholipid can be saturated or unsaturated but not both.
    (this multiple choice question has been scrambled)
  22. A highly non-fluid phospholipid membrane would be expected to contain
    a.  cholesterol
    b.  saturated fatty acid tails
    c.  unsaturated fatty acid tails
    d.  Both a and b
    • a.  cholesterol
    • b.  saturated fatty acid tails
    • d.  Both a and b
  23. Consider a membrane protein that is glycosylated (sugar group added) in the Golgi. Which region of the plasma membrane would the glycosylated portion of the protein be expected to be situated when inserted in the plasma membrane by a vesicle?
    A. inside the phospholipid bilayer
    B. cytosolic face ( intracellular)
    C.  non-cytosolic face (extracellular)
    C.  non-cytosolic face (extracellular)
    (this multiple choice question has been scrambled)
  24. The redistribution of specific phospholipids from one side of the phospholipid bilayer to the other side takes place in the ________________ by the action of the enzyme _____________.
    A.  ER; scramblase
    B.  ER; flippase
    C.  Golgi; scramblase
    D.  Golgi: flippase
    D.  Golgi: flippase
    (this multiple choice question has been scrambled)
  25. A molecule that can pass through the plasma membrane by simple diffusion
    a.  requires some form of energy.
    b.  must be going down its concentration gradient.
    c. is generally small and uncharged.
    d.  Both b and c
    • b.  must be going down its concentration gradient.
    • c. is generally small and uncharged.
    • d.  Both b and c
  26. How is the energy of ATP “utilized” or “transferred” in the process of active transport?
    A.  An inorganic phosphate is generated when ATP is hydrolyzed to ADP.
    B.  The molecule being transported is phosphorylated when ATP is hydrolyzed to ADP
    C.  High energy electrons are transferred.
    D.  The transporter is phosphorylated when ATP is hydrolyzed to ADP.
    D.  The transporter is phosphorylated when ATP is hydrolyzed to ADP.
    (this multiple choice question has been scrambled)
  27. What most likely would happen if the Na+K+ Pump stopped working in a cell?
    A.  The inside of the cell would be more negative.
    B.  The cell would shrink by pumping out water.
    C. The inside of the cell would have fewer ions.
    D.  The cell would swell by taking up water.
    D.  The cell would swell by taking up water.
    (this multiple choice question has been scrambled)
  28. Consider the Na+K+ pump (transporter).  How is it possible for the pump to transport the ions in opposite directions?
    A.  The Na+ and K+ ions are located on different sides of the plasma membrane, so the same binding site can be used on each side of the membrane to transport them in opposite directions.
    B. The transporter has one binding site that is randomly changing it shape to fit either Na+ or K+.  Thus, sometimes Na+ is pumped and other times K+.
    C.  The transporter has two unique binding sites that are exposed on each side of the membrane, one binding site for Na+ and one binding site for K+.   
    D.  The pump has one binding site for both ions but this binding site can change shape on each side of the membrane when the transporter is phosphorylated      
    C.  The transporter has two unique binding sites that are exposed on each side of the membrane, one binding site for Na+ and one binding site for K+.
    (this multiple choice question has been scrambled)
  29. The electrochemical gradient of K+ depends on which of the following
    a.  the concentration of the Na+ inside and outside the cell.
    b.  the concentration of K+ ions inside and outside the cell.
    c.  the membrane potential.
    d.  Both a and c.
    • a.  the concentration of the Na+ inside and outside the cell.
    • c.  the membrane potential.
    • d.  Both a and c.
  30. Signal sequences that direct proteins to the correct cellular compartments are _________.
    A.  encoded in the amino acid sequence.
    B.  added to a protein by a protein translocator.
    C.  added to the protein during protein synthesis by the ribosome
    D.  added to proteins after protein synthesis.
    A.  encoded in the amino acid sequence.
    (this multiple choice question has been scrambled)
  31. After isolating the rough endoplasmic reticulum from the rest of the cytoplasm, you purify the RNAs attached to it. Which of the following proteins do you expect the RNA from the rough endoplasmic reticulum to encode?
    a.  soluble secreted proteins
    b.  ER membrane proteins
    c.  plasma membrane proteins
    d.  all of the above
    d.  all of the above
  32. A ribosome synthesizing a protein that contains an ER signal sequence becomes bound to the rough ER because
    A.  A protein complex binds to the nascent protein chain being made, which then binds it to a receptor on the ER.
    B.  A cytoplasmic protein complex binds the ribosomes, which then attaches the translation complex to the ER
    C.  the ribosome, itself, with the translation complex, binds to specific lipids in the ER.
    D.  A protein complex binds to the mRNA, which then binds it to a receptor on the ER.
    A.  A protein complex binds to the nascent protein chain being made, which then binds it to a receptor on the ER.
    (this multiple choice question has been scrambled)
  33. Removal of ALL signal sequences from a protein would result in the protein being localized to
    A.  secreted from the cell
    B.  the cytoplasm
    C.  the nucleus
    D.  the ER lumen
    B.  the cytoplasm
    (this multiple choice question has been scrambled)
  34. Proteins targeted to the lysosomes will contain how many signal sequences?
    A. none       
    B. three
    C. one         
    D. two              
    D. two
    (this multiple choice question has been scrambled)
  35. Lysosomes function to
    a.  digest of worn-out mitochondria.
    b.  digest LDL particles and release of cholesterol in the cell.
    c.  degrade proteins and lipids.
    d.  All of the above
    d.  All of the above
  36. The site of new membrane synthesis is the
    A. cytoplasm
    B.  ER
    C. trans-Golgi
    D.  cis-Golgi
    B.  ER
    (this multiple choice question has been scrambled)
  37. The ER is involved in protein quality control in what way?
    A.  ER proteins with mutations are not moved through the protein translocator.
    B.  Proteins that are folded incorrectly are degraded in the lumen of the ER.
    C.  Proteins that are folded incorrectly are rejected from the ER.
    D.  Proteins that are folded incorrectly are retained in the ER by binding to chaperones.
    D.  Proteins that are folded incorrectly are retained in the ER by binding to chaperones.
    (this multiple choice question has been scrambled)
  38. The v- and t-SNARE proteins are involved in what process?
    A.  targeting of transport vesicle with target membrane.
    B.  packaging of cargo into vesicles.
    C.  fusion of transport vesicle with a target membrane.
    D.  formation of vesicles.
    C.  fusion of transport vesicle with a target membrane
    (this multiple choice question has been scrambled)
  39. The process for targeting proteins to the nucleus, mitochondria, chloroplast and peroxisomes includes this similar first step.  What is this step?
    A.  The protein is first completely synthesized on free ribosomes in the cytosol and then interacts with a targeting protein (receptor).
    B. The protein is first passed through the endomembrane system and then targeted to these locations.
    C.  The newly made protein binds directly to the protein translocator.
    D. The N-terminus of the protein appears and then the ribosome-translation complex is moved to these locations.
    A.  The protein is first completely synthesized on free ribosomes in the cytosol and then interacts with a targeting protein (receptor).
    (this multiple choice question has been scrambled)
  40. During which phase of the cell cylce does the majority of cell growth take place?
    A. g1
    B. g2
    C. s
    D. m
    A. G1
    (this multiple choice question has been scrambled)
  41. What is the major reason for activity of a specific cyclin-dependent kinase restricted to a particular period of the cell cycle?
    Because the kinase sub-unit only appears during that defined period of the cell cycle
  42. How does the cylcin-cdk control the actual start of DNA replication? That is, what does the cyclin-cdk do to make DNA replication start?
    phosphorylate the helicase
  43. The function of Rb in cell cycle regulation is to
    bind to and block the function of various transcription factors and stop the cell in G1
  44. Which is not a way by which the activity of cyclin-cdks can be modified?
    methylation of the cyclin subunit
  45. How does the RAS pathway connect to cell cycle regualtion and control progression through G1 phase of the cell cycle?
    the ERK kinase phosphorylates a transcription factor that turns on the cyclin D gene
  46. Cyclin B-cdk1 controls the events of mitosis by doing what?
    • phosphorylating proteins involved in chromosome condensation
    • phosphorylating proteins involved in nuclear membrane breakdown
    • phosphorylating proteins involved in microtubule formation
  47. Checkpoint control during M phase involves sensing what?
    if the chromosomes are properly attached to the spindle
  48. When DNA undergoes damage in a particular cell, it can stop entry into the cell cycle by increasing the activity of p53. How does p53 stop cell cycle production?
    It increases expression of a cyclin E-cdk2 inhibitor, stopping entry into S- phase
  49. Steroid hormones can function as what?
    nuclear transcription factors
  50. During what phase of the cell cycle is there some cell growth and preparation for mitosis?
    G2
  51. Which is not a way by which Ca2+ is kept at a low concentration in the cytosol of the cell
    pumped into the nucleus
  52. Activated G protein can activate phospholipase C. What is the specific activity of phospholipase  C?
    Breakdown the phospholipid PIP3 to IP3 and DAG
  53. The hormone acetylcholine causes the pancreas to release amylase (a digestive protein). What is the likely RECEPTOR; ACTIVATED ENZYME; INTRACELLULAR 2ND MESSENGER
    G-protein coupled receptor; phospholipase C; Ca2+
  54. Both G-protein coupled receptors and enzyme coupled receptors use a common mechanism to modify cell function. What is it?
    Phosphorylate proteins involved in cell function
  55. Activation of enzyme linked receptors includes all of the following except
    internalization of the receptors

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