Card Set Information
Drug of choice for generalized seizures in children
Is physically addictive
Not used in breastfeeding due to possible liver toxicity
3rd line drug-recommended in patients that didn’t respond to other drugs and the epilepsy is so severe that additional risk is deemed necessary
Gingival hyperplasia and increase in body hair/hirsutism
Phenytoin that is given IV
How are the new drugs usually eliminated from the body? Liver or kidney
D/C if rash develops, and how do you prevent rash from occurring
Lamotrigine. Give drug slowly.
Visual field defects in 1/3 of patients delayed FDA approval in US
Inducers of microsomal enzymes (3) and what does this mean?
Carbamazepine, phenytoin, phenobarbital ….idk what it means
Has the longest half-life
Is an adjunct therapy with partial seizure
For Catamenial epilepsy
Aplastic anemia risk (2)
Lamotrigine-liver or kidney?
Use with extreme caution in renal failure patients
When should IV drugs be administered in status epilepticus
After 30 min of cont. seizure
Decreased effectiveness of OCP (4)
Topiramate, Phenytoin, Carbamazepine, phenobarbital
Increased spina bifida risk (2)
Carbamazepine (10X) Valproic Acid (20X)
For Lennox –Gousttaut and what is this?
Rufinamide. d/o of multiple diff seizure types
Drug of choice for absence seizures
Drug of choice for Status Epilepticus? What else can be used? Why is this not drug of choice?
Diazepam or Lorazepam.
can be used but doesn’t act as quickly
Must participate in a special program-lots of paperwork
Universal drugs (2)
Valproic acid, Lamotrigine
What do you give if status epilepticus isnt being controlled after 1 hr and you already gave 1st line drugs
May temporarily suppress WBC counts
What drug do you give for status epilepticus if you don’t have control after 2nd line drug?
Should a pregnant lady take anti-seizure meds
Drug of choice in febrile infant seizures and why
Phenobarbital – because it is easily absorbed
Steady state stabilized quickly
Levetiracetam (leve=level=levels/steady quickly)
May aggravate absence seizures
Can raise phenobarbital levels by 40%
Drug and route of administration for treating status epilepticus out of the hospital
Has minimal effects on behavior and therefore is OK in children
Which drug is <1% bound
Must monitor blood levels
Can produce Kidney stones (2)