Anti-seizure Medications

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Author:
Pandora320
ID:
291013
Filename:
Anti-seizure Medications
Updated:
2014-12-08 10:46:57
Tags:
Pharmacology
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Description:
Pharmacology PAP-570
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  1. Drug of choice for generalized seizures in children
    Carbamazepine
  2. Is physically addictive
    Phenobarbital
  3. Not used in breastfeeding due to possible liver toxicity
    Valproic acid
  4. 3rd line drug-recommended in patients that didn’t respond to other drugs and the epilepsy is so severe that additional risk is deemed necessary
    Felbamate
  5. Gingival hyperplasia and increase in body hair/hirsutism
    Phenytoin
  6. Phenytoin that is given IV
    Fosphenytoin
  7. How are the new drugs usually eliminated from the body? Liver or kidney
    Kidney
  8. D/C if rash develops, and how do you prevent rash from occurring
    Lamotrigine. Give drug slowly.
  9. Visual field defects in 1/3 of patients delayed FDA approval in US
    Vigabatrin
  10. Inducers of microsomal enzymes (3) and what does this mean?
    Carbamazepine, phenytoin, phenobarbital ….idk what it means
  11. Has the longest half-life
    Phenobarbital
  12. Is an adjunct therapy with partial seizure
    Pregabalin
  13. For Catamenial epilepsy
    Acetazolamide
  14. Aplastic anemia risk (2)
    Carbamazepine, Felbamate
  15. Lamotrigine-liver or kidney?
    LIVER
  16. Use with extreme caution in renal failure patients
    Ethosuximde
  17. Replaced gabapentin
    Pregabalin
  18. When should IV drugs be administered in status epilepticus
    After 30 min of cont. seizure
  19. Decreased effectiveness of OCP (4)
    Topiramate, Phenytoin, Carbamazepine, phenobarbital
  20. Increased spina bifida risk (2)
    Carbamazepine (10X) Valproic Acid (20X)
  21. For Lennox –Gousttaut and what is this?
    Rufinamide. d/o of multiple diff seizure types
  22. Drug of choice for absence seizures
    Ethosuximde
  23. Drug of choice for Status Epilepticus? What else can be used? Why is this not drug of choice?
    • Diazepam or Lorazepam.
    • Phenytoin/Fosphenytoin
    • can be used but doesn’t act as quickly
  24. Must participate in a special program-lots of paperwork
    Vigabatrin
  25. Universal drugs (2)
    Valproic acid, Lamotrigine
  26. What do you give if status epilepticus isnt being controlled after 1 hr and you already gave 1st line drugs
    Phenobarbitol
  27. May temporarily suppress WBC counts
    Carbamazepine
  28. What drug do you give for status epilepticus if you don’t have control after 2nd line drug?
    Propofol (IV)
  29. Should a pregnant lady take anti-seizure meds
    Yes
  30. Drug of choice in febrile infant seizures and why
    Phenobarbital – because it is easily absorbed
  31. Steady state stabilized quickly
    Levetiracetam (leve=level=levels/steady quickly)
  32. May aggravate absence seizures
    Oxcarbazepine
  33. Can raise phenobarbital levels by 40%
    Valproic acid
  34. Drug and route of administration for treating status epilepticus out of the hospital
    Diastat-rectal form
  35. Has minimal effects on behavior and therefore is OK in children
    Valproic acid
  36. Which drug is <1% bound
    Ethosuximide
  37. Must monitor blood levels
    Phenytoin
  38. Can produce Kidney stones (2)
    Topiramate Zonisamide

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