antiseizure

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thedewhub
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291019
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antiseizure
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2014-12-08 11:53:22
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antiseizure
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antiseizure
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  1. regional seizures in the brain
    Partial or local seizures -
  2. global involvement of the brain in a seizure
    Generalized seizures -
  3. {10%} cortical focal [Phenytoin, Carbamazepine, Valproate, newer Lamotrigine, Levetiracetam, Topiramate, Oxcarbazepine, Zonisamide] patient is conscious and aware 2. highly localized; minimal spread motor cortex - one limb jerking visual cortex - light flashes or colors somatosensory ctx. - tingling or numbness
    Simple partial seizures
  4. psychomotor epilepsy-[Carbamazepine, Phenytoin, Valproate,newer Lamotrigine, Levetiracetam, Topiramate, Oxcarbazepine, Zonisamide], usually bilateral limb involvement, altered level of consciousness doesn’t fall to the ground - just unaware, most difficult to treat pharmacologically***
    Complex partial seizures -
  5. {10%} partial seizure preceding a tonic-clonic attack with convulsions. [Phenytoin, Carbamazepine, Valproate newer Lamotrigine, Levetiracetam, Topiramate,Oxcarbazepine, Zonisamide]
    Partial seizures secondarily generalized
  6. [Ethosuximide > Valproate or Lamotrigine] usually children, blank stare, 10 sec
    Absence (petit mal) seizures
  7. [Valproate, Lamotrigine]sudden stiffening, frequently fall backwards, loss of consciousness
    Tonic seizures
  8. [Valproate, Lamotrigine] sudden loss of postural tone, usually fall forward
    Atonic seizures
  9. [Valproate, Lamotrigine]
    Clonic and myoclonic seizures
  10. [Lorazepam, Diazepam, Phenytoin and/or Propofol]A continuous seizure state that can be fatal.
    Status epilepticus
  11. is a heterogeneous group of disorders characterized by RECURRENT seizures.
    Epilepsy
  12. Drug of choice for generalized seziures in children
    Carbamazepine
  13. Is physically addictive
    Phenobarbital
  14. Not used in breastfeeding due to possible liver toxicity
    Valproic acid
  15. 3rd line drug-recommended in patients that didn’t respond to other drugs and the epilepsy is so severe that additional risk is deemed necessary
    Felbamate
  16. Gingival hyperplasia and increase in body hair/hirsutism
    Phenytoin
  17. Phenytoin that is given IV
    Fosphenytoin
  18. How are the new drugs usually eliminated from the body? Liver or kidney
    Kidney
  19. D/C if rash develops, and how do you prevent rash from occurring
    Lamotrigine. Give drug slowly.
  20. Visual field defects in 1/3 of patients delayed FDA approval in US
    Vigabatrin
  21. Inducers of microsomal enzymes (3) and what does this mean?
    Carbamazepine, phenytoin, phenobarbital ….idk what it means
  22. Has the longest half-life
    Phenobarbital
  23. Is an adjunct therapy with partial seizure
    Pregabalin
  24. For Catamenial epilepsy
    Acetazolamide
  25. Aplastic anemia risk (2)
    Carbamazepine, Felbamate
  26. Lamotrigine-liver or kidney?
    LIVER
  27. Use with extreme caution in renal failure patients
    Ethosuximde
  28. Replaced gabapentin
    Pregabalin
  29. When should IV drugs be administered in status epilepticus
    After 30 min of cont. seizure
  30. Decreased effectiveness of OCP (4)
    Topiramate, Phenytoin, Carbamazepine, phenobarbital
  31. Increased spina bifida risk (2)
    Carbamazepine (10X) Valproic Acid (20X)
  32. For Lennox –Gousttaut and what is this?
    Rufinamide. d/o of multiple diff seizure types
  33. Drug of choice for absence seizures
    Ethosuximde
  34. Drug of choice for Status Epilepticus? What else can be used? Why is this not drug of choice?
    Diazepam or Lorazepam. Phenytoin/Fosphenytoin can be used but doesn’t act as quickly
  35. Must participate in a special program-lots of paperwork
    Vigabatrin
  36. Universal drugs (2)
    Valproic acid, Lamotrigine
  37. What do you give if status epilepticus isnt being controlled after 1 hr and you already gave 1st line drugs
    Phenobarbitol
  38. May temporarily suppress WBC counts
    Carbamazepine
  39. What drug do you give for status epilepticus if you don’t have control after 2nd line drug?
    Propofol (IV)
  40. Should a pregnant lady take antiseizure meds
    Yes
  41. Drug of choice in febrile infant seizures and why
    Phenobarbital – because it is easily absorbed
  42. Steady state stabilized quickly
    Levetiracetam (leve=level=levels/steady quickly)
  43. May aggravate absence seizures
    Oxcarbazepine
  44. Can raise phenobarbital levels by 40%
    Valproic acid
  45. Drug and route of administration for treating status epilepticus out of the hospital
    Diastat-rectal form
  46. Has minimal effects on behavior and therefore is OK in children
    Valproic acid
  47. Which drug is <1% bound
    Ethosuximide
  48. Must monitor blood levels
    Phenytoin
  49. Can produce Kidney stones (2)
    Topiramate Zonisamide

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