Chagas disease (topical regions) from reduviid bugs (not bedbugs); hard to clear trypanosomes in peripheral blood. Symptoms begin with a skin lesion or unilateral periorbital edema, then fever, malaise, generalized lymphadenopathy, and hepatosplenomegaly. Years later can develop fibrosis around heart (cardiomyopathy) from nerve cell ganglia destruction; and gut (megacolon). Treat with nifurtimox or benznidazole, also supportive care for heart failure, heart block, arrhythmia, esophageal stricture.
Protozoa Trypanosoma cruzi