Immuno MABs 1

Card Set Information

Author:
kyleannkelsey
ID:
291378
Filename:
Immuno MABs 1
Updated:
2014-12-12 13:32:42
Tags:
Immuno MABs
Folders:
Immuno MABs
Description:
Immuno MABs
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kyleannkelsey on FreezingBlue Flashcards. What would you like to do?


  1. Muromonab-CD3
    • Type: 100% mouse
    • Directed against: CD3 of T lymphocytes
    • Function: Reduces T lymphocytes and CD3 expression on T lymphocytes
    • Use: Prevent organ graft rejection by or depletes T cells prior to BM transplant
  2. Abciximab brand name is:
    Centorex, Reopro
  3. Centorex, Reopro generic name is:
    Abciximab
  4. Abciximab (Centorex, Reopro)
    • Type: Chimeric
    • Directed against: Glycoprotein (GP) IIb/IIIa receptors = integrin family of adhesion molecules
    • Function: inhibits monocyte and platelet adhesion through steric hindrance of the receptor, inhibits pro-coagulation vitronectin receptors and proliferation of endothelial and smooth muscle cell
    • Use: Antithrombotic, ED MI
  5. What is the brand name for Palvizumab:
    Synagis
  6. What is the generic name for Synagis?
    Palvizumab
  7. Palvizumab (Synagis)
    • Type: CDR grafted/Humanized/Human like
    • Directed against: RSV
    • Use: Serious LRTI caused by respiratory syncytial virus (RSV)
  8. What is the brand name for Adalimumab?
    Humira
  9. What is the generic name for Humira?
    Adalimumab
  10. Adalimumab (humira)
    • Type: 100% human
    • Directed against: TNF alpha
    • Function: Blocks TNF-a interaction with p55 and p75 cell surface TNF-a receptors, decreases acute phase proteins, serum cytokines, and metalloproteinase
    • Use: w or w/o methotrexate which reduces its clearance, to fight Adult and Juvenile Rheumatoid arthritis, Crohn’s disease, psoriatic arthritis and spondylitis
  11. What are the functions of TNF alpha?
    • Mediator of inflammation
    • Endothelial cells = will increase the expression of adhesion molecules
    • Increases the adhesiveness of PMNs to adhesion molecules
    • Activates inflammatory cytokines and leukocytes
    • Stimulates production of TNF alpha itself, IL-1 and IL-6
    • Release of chemokines
    • Causes acute phase response or the production of acute phase proteins
  12. What is the brand name for Infliximab?
    Remicade
  13. What is the generic name for Remicade?
    Infliximab
  14. Infliximab (Remicade)
    • Type: Chimeric
    • Direct against: TNF alpha
    • Function: Stops release of IL-1 and IL-6 (and other TNF-alpha effects), suppresses the expression of adhesion molecules, reduces inflammation and the acute phase response
    • Use: rheumatoid arthritis and Crohn’s Disease
  15. What is the brand name for Golimumab?
    Simponi
  16. What is the generic name for Simponi?
    Golimumab
  17. Golimumab (Simponi)
    • Type: 100% human
    • Direct against: TNF-alpha
    • Use: Monthly treatment for moderate to severe rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and ulcerative colitis in patients not taking taking abatacept, kineret, or other TNFa blockers
  18. What is the brand name for Certolizumab?
    Cimzia
  19. What is the generic name for Cimzia?
    Certolizumab
  20. Certolizumab (Cimzia)
    • Type: CDR grafted/Humanized/Human like
    • Direct against: membrane-bound and soluble human TNFα
    • Function: Dose dependent neutralization of TNF-a without antibody-dependent cellular cytotoxicity, complement activation, or apoptosis in T cells or macrophages
    • Use: Rheumatoid arthritis and Crohn’s disease (other autoimmune off label)
  21. What is the brand name for Natalizumab?
    Tysabri
  22. What is the generic name for Tysabri?
    Natalizumab
  23. Natalizumab (Tysabri)
    • Type: CDR grafted/Humanized/Human like
    • Direct against: alpha-4 integrin (adhesion molecule)
    • Function: interferes with the cellular traffic (T cells crossing BBB) and antiinflammatory
    • Use: multiple sclerosis and Crohn’s disease
  24. What are the notable SE of Natlizumab (Tysabri)?
    Progressive multifocal leukoencephalopathy (PML), which is an opportunistic infection caused by John Cunningham (JC) virus
  25. What MAB causes progressive multifocal leukoencephalopathy (PML), which is an opportunistic infection caused by John Cunningham (JC) virus?
    Natlizumab (Tysabri)
  26. What is the brand name for Tocilizumab?
    Actemra
  27. What is the generic name for Actemra?
    Tocilizumab
  28. Tocilizumab (Actemra)
    • Type: CDR grafted/Humanized/Human like
    • Direct against: soluble & membrane bound IL-6 receptors
    • Use: SQ q/ or w/o methotrexate for the treatment of moderate to severe rheumatoid arthritis and systemic juvenile idiopathic arthritis
  29. What MABs are used with Methotrexate?
    • Adalimumab (Humira)
    • Tocilizumab (Actemra)
  30. What is the brand name for Belimumab?
    Benlysta
  31. What is the generic name for Benlysta?
    Belimumab
  32. Belimumab (Benlysta)
    • Type: 100% human
    • Direct against: B-cell activating factor (BAFF or B-lymphocyte stimulator)
    • Function: Inhibits B cell development and survival
    • Use: Systemic lupus erythematosus
  33. What is the Brand name for Daclizumab?
    Zenapax
  34. What is the generic name for Zenapax
    Daclizumab
  35. Daclizumab (Zenapax)
    • Type: CDR grafted/Humanized/Human like
    • Direct against: alpha subunit of IL-2 receptors
    • Function: Inhibits IL-2 mediated activation of T cells
    • Use: Immunosuppression for kidney transplantation
  36. What is the brand name for Basiliximab?
    Simulect
  37. What is the generic name for Simulect?
    Basiliximab
  38. Basiliximab (Simulect)
    • Type: Chimeric
    • Direct against: Alpha subunit of IL-2 receptors (CD-25 antigen)
    • Function: Inhibits IL-2 mediated activation of T cells
    • Use: Immunosuppression
  39. What MABs inhibit IL-2 mediated activation of T cells by targeting the alpha chain of the IL-2 receptor?
    • Basiliximab (Simulect)
    • Daclizumab (Zenapax)
  40. What is the brand name for Efalizumab?
    Raptiva
  41. What is the generic name for Efalizumab?
    Raptiva
  42. Efalizumab (Raptiva)
    • Type:
    • Direct against: LFA-1 and ICAM-1
    • Function: inhibits adhesion of T cells to other cell types by inhibiting the binding of LFA-1 (CD 11) to ICAM-1. Inhibition of T cell proliferation, cytokine release, migration and interaction with tissue-specific cells
    • Use: Psoriasis

What would you like to do?

Home > Flashcards > Print Preview