Immuno MABs 2

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kyleannkelsey
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291409
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Immuno MABs 2
Updated:
2014-12-12 22:05:28
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Immuno MABs
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Immuno MABs
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Immuno MABs
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  1. What is the brand name for Ustekinumab?
    Stelara
  2. What is the generic name for Stelara?
    Ustekinumab
  3. Ustekinumab (Stelara)
    • Type: 100% human IgG1α
    • Direct against: p40 subunit of the IL-12 (NK stimulatory factor or cytotoxic lymphocyte maturation factor) and IL-23
    • Function: Inhibit NK maturation, differentiation of CD4+ T cells into TH17 cells and the subsequent production of pro-inflammatory IL-17 (which in turn stimulates IL-1,6 and TNF-a)
    • Use: Anti-inflammatory
  4. What B cells do not express CD20+?
    Progenitor Stem Cells and Plasma cells
  5. Which MABs are directed at TNF-alpha?
    • Adalimumab (Humira)
    • Inflximab (Remicade)
    • Golimumab (Simponi)
    • Certolizumab (Cimzia)
  6. What is the brand name for Rituximab?
    • Rituxan
    • What is the generic name for Rituximab?
    • Rituxan
  7. Rituximab (Rituxan)
    • Type: Chimeric
    • Direct against: CD20
    • Function: Fab binds to CD20 and Fc domain recruits immune effector cells and mediators for B cell lysis
    • Use: Relapsed refractory, low grade or follicular B cell lymphoma (CD20+) and non-Hodgkin’s lymphoma
  8. What is the brand name for Trastuzumab?
    Herceptin
  9. What is the generic name for Herceptin?
    Trastuzumab
  10. Trastuzumab (Herceptin)
    • Type: CDR grafter/Humanized/Human like
    • Direct against: human epidermal growth factor type 2 receptor protein (HER-2) (Tyrosine Kinase involved in cell growth)
    • Function: inhibits the proliferation of tumor cells over expressing HER-2, causes down regulation and decreased cell growth signaling and lysis via antibody-dependent cell-mediated cytotoxicity
    • Use: HER-2 positive Metastatic Breast Cancer (with paclitaxel if previous Chemo)
  11. What are the unique SE for Trastuzumab (Herceptin)
    • Ventricular dysfunction and CHF
    • Exhibit symptoms of cardiac dysfunction, dyspnea, peripheral edema and reduced ejection fraction
    • Left ventricular function must be evaluated
    • Combo with anthracyclin and cyclophosphamide = severe cardiomyopathy
  12. What MAB causes Ventricular dysfunction and CHF, with symptoms of cardiac dysfunction, dyspnea, peripheral edema and reduced ejection fraction? Thus, must be given only in patients evaluated for Left ventricular function?
    Trastuzumab (Herceptin)
  13. _____________________ in Combo with anthracyclin and cyclophosphamide = severe cardiomyopathy.
    Trastuzumab (Herceptin)
  14. What is the brand name for Alemtuzumab?
    Campath
  15. What is the generic name for Campath?
    Alemtuzumab
  16. Alemtuzumab (Campath)
    • Type: CDR grafter/Humanized/Human like
    • Direct against: CD52 present on the surface of normal and malignant T and B cells, NK cells and monocytes or macrophages
    • Function: antibody-dependent lysis of target cells
    • Use: B cell chronic lymphocytic leukemia in patients who do not respond to the standard
  17. CD52 is not present on what types of cells?
    Erythrocytes and stem cells
  18. What is the brand name for Ofatumumab?
    Arzerra
  19. What is the generic name for Arzerra?
    Ofatumumab
  20. Ofatumumab (Arzerra)
    • Type: 100% human
    • Direct against: CD20 w/ different epitope than rituximab
    • Function: inhibits early stage B cell activation
    • Use: Non- first line treatment for chronic lymphocytic leukemia which is refractory to fludarabine and Alemtuzumab (Campath)
  21. What is the brand name for Trastuzumab emtansine?
    Kadcyla
  22. What is the generic name for Kadcyla?
    Trastuzumab emtansine
  23. Trastuzumab emtansine (Kadcyla)
    • Type: Conjugated Herceptin w/ cytotoxic mertansine
    • Direct against: HER-2
    • Function: Specifically targets cancer cells and kills them through tubulin inhibition
    • Use: HER-2 + metastatic breast cancer, previously treated with Herceptin or have re-developed tumor within six months of a therapy
  24. What is the brand name for Gemtuzumab-ozogamacin?
    Mylotarg
  25. What is the generic name for Mylotarg?
    Gemtuzumab-ozogamacin
  26. Gemtuzumab-ozogamacin (Mylotarg)
    • Type: conjugated CDR grafted monoclonal antibody (IgG4)
    • Direct against: CD33 of Leukemic blast and normal myelomocytic cells (not on hematopoietic stem cells)
    • Function: Conjugated with cytotoxic calicheamicin
    • Use: CD33 positive acute myeloid leukemia
  27. What is the brand name for Ibritumomab?
    Zevalin
  28. What is the generic name for Zevalin?
    Ibritumomab
  29. Ibritumomab (Zevalin)
    • Type: 100% murine MAB (IgG1) conjugated to a linker and chelated to either Indium-111 or Yttrium-90
    • Direct against: CD20
    • Function: Delivers radiation to CD20 + cells, kills by free radical formation
    • Use: Refractory low grade, follicular, or transformed B cell non-Hodgkin’s lymphoma or w/ rituximab in refractory follicular non-Hodgkin’s lymphoma
  30. How is Ibritumomab (Zevalin) administered?
    • Usually Rituximab is given
    • W/in 1 hour: Indium 111 is administered
    • 5-7 days after: Yttrium 90 is administered

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