Drugs.txt

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Author:
rere_girl4ever
ID:
291432
Filename:
Drugs.txt
Updated:
2014-12-13 11:15:14
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pharmacology usmle
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pharmacology
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Pharmacology usmle
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  1. Intavenvous form of Penicillin?
    Penicillin G
  2. Intramuscular form of Penicillin?
    Penicillin G
  3. Oral form of Penicillin?
    Penicillin V
  4. What is the MOA of Penicillin?
    • Bind penicillin-binding proteins (transpeptidases).
    • Block transpeptidase cross-linking of peptidoglycan.
    • Activate autolytic enzymes
  5. This drug binds penicillin-binding proteins (transpeptidases).
    Penicillin
  6. This drug blocks transpeptidase cross-linking of peptidoglycan.
    Penicillin
  7. This drug works by activates autolytic enzymes of the bacteria.
    Penicillin
  8. Uses of Penicillin?
    • Mostly used for gram-positive organisms (S. pneumoniae, S. pyogenes, Actinomyces)
    • Also used for N. meningitidis and T. pallidum.
    • Bactericidal for gram-positive cocci, gram-positive rods, gram negative cocci, and spirochetes
  9. Side effects of Penicillin?
    Hypersensitivity reactions, hemolytic anemia
  10. What is Penicillinase?
    A type of beta-lactamase which cleaves -lactam ring.
  11. Resistance to this drug: Penicillinase in bacteria (a type of  beta-lactamase) cleaves -lactam ring.
    • Penicillin
    • Ampicillin
    • Amoxicillin
  12. What are the Penicillinase-sensitive penicillins?
    Ampicillin, Amoxicillin
  13. These drugs combine with Clavulanic acid to protect against beta-lactamase.
    Ampicillin Amoxicillin
  14. What are the uses of Ampicillin and Amoxicillin?
    • Haemophilus influenzae
    • E. coli
    • Listeria monocytogenes
    • Proteus mirabilis
    • Salmonella
    • Shigella
    • enterococci
  15. What are the side effects of Ampicillin, Amoxicillin?
    • Hypersensitivity reactions
    • Rash
    • Pseudomembranous colitis
  16. Between Amoxicillin and Ampicillin, which one has a greater Oral Bioavalability?
    Amoxicillin
  17. What are the Penicillinase-resistant penicillins? Why are they resistant?
    • Oxacillin
    • Nafcillin
    • Dicloxacillin
    • Because bulky R group blocks access of beta-lactamase to beta-lactam ring.
  18. These drugs are penicillinase resistant because bulky R group blocks access of beta-lactamase to beta-lactam ring.
    • Oxacillin
    • Nafcillin
    • Dicloxacillin
  19. What is the MOA, use and side effects of Oxacillin?
    • MOA: Same as penicillin. Penicillinase resistant because bulky R group
    • blocks access of beta -lactamase to beta-lactam ring.
    • CLINICAL USE: S. aureus (except MRSA)
    • TOXICITY: Hypersensitivity reactions, interstitial nephritis.
  20. What is the MOA, use and side effects of Nafcillin?
    • MOA: Same as penicillin. Penicillinase resistant because bulky R group
    • blocks access of beta-lactamase to beta-lactam ring.
    • CLINICAL USE: S. aureus (except MRSA)
    • TOXICITY: Hypersensitivity reactions, interstitial nephritis.
  21. What is the MOA, use and side effects of Dicloxacillin?
    • MOA: Same as penicillin. Penicillinase resistant because bulky R group
    • blocks access of beta-lactamase to beta-lactam ring.
    • CLINICAL USE: S. aureus (except MRSA)
    • TOXICITY: Hypersensitivity reactions, interstitial nephritis.
  22. This antibiotic can cause interstitial nephritis.
    Penicillinase-resistant penicillins: Oxacillin, Nafcillin, Dicloxacillin
  23. Which drugs are the antipseudomonals?
    Ticarcillin, piperacillin
  24. What is the MOA, use and side effects of Ticarcillin?
    • MOA: Bind penicillin-binding proteins (transpeptidases). Block transpeptidase cross-linking of peptidoglycan. Activate autolytic enzymes
    • CLINICAL USE Pseudomonas spp. and gram-negative rods; susceptible to penicillinase; use with -lactamase
    • inhibitors.
    • TOXICITY Hypersensitivity reactions
  25. What is the MOA, use and side effects of Piperacillin?
    • MOA: Bind penicillin-binding proteins (transpeptidases). Block transpeptidase cross-linking of peptidoglycan. Activate autolytic enzymes
    • CLINICAL USE Pseudomonas spp. and gram-negative rods; susceptible to penicillinase; use with -lactamase
    • inhibitors.
    • TOXICITY Hypersensitivity reactions
  26. What are the beta-lactamase inhibitors?
    • Clavulanic Acid
    • Sulbactam
    • Tazobactam
    • Often added to penicillin antibiotics to protect the antibiotic from destruction by beta-lactamase (penicillinase).
  27. What is the use of Clavulanic Acid?
    Often added to penicillin antibiotics to protect the antibiotic from destruction by beta -lactamase (penicillinase)
  28. What is the use of Sulbactam?
    Often added to penicillin antibiotics to protect the antibiotic from destruction by beta-lactamase (penicillinase)
  29. What is the use of Tazobactam?
    Often added to penicillin antibiotics to protect the antibiotic from destruction by beta-lactamase (penicillinase).

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