respiratory drugs

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rere_girl4ever
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291468
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respiratory drugs
Updated:
2014-12-13 19:00:08
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respiratory drugs
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respiratory drugs
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respiratory drugs
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  1. What are the 1st generation H1 blockers, their MOA, use and toxicity?
    • Diphenhydramine
    • Dimenhydrinate
    • Chlorpheniramine
    • Names contain “-en/-ine” or “-en/-ate.”
    • CLINICAL USES: Allergy, motion sickness, sleep aid.
    • TOXICITY: Sedation, antimuscarinic, anti-a-adrenergic.
  2. What are the 2nd generation H1 blockers, what are their uses and side effects?
    • Loratadine
    • Fexofenadine
    • Desloratadine
    • Cetirizine
    • Names usually end in “-adine.”
    • CLINICAL USES: Allergy.
    • TOXICITY: Far less sedating than 1st generation because of decreased entry into CNS.
  3. What is the MOA, use and side effects of Diphenhydramine?
    • MECHANISM: H1 blocker (1st generation)
    • CLINICAL USES: Allergy, motion sickness, sleep aid.
    • TOXICITY: Sedation, antimuscarinic, anti-a-adrenergic.
  4. What is the MOA, use and side effects of Dimenhydrinate?
    • MECHANISM: H1 blocker (1st generation)
    • CLINICAL USES: Allergy, motion sickness, sleep aid.
    • TOXICITY: Sedation, antimuscarinic, anti-a-adrenergic.
  5. What is the MOA, use and side effects of Chlorpheniramine?
    • MECHANISM: H1 blocker (1st generation)
    • CLINICAL USES: Allergy, motion sickness, sleep aid.
    • TOXICITY: Sedation, antimuscarinic, anti-a-adrenergic.
  6. What is the MOA, use and side effects of Loratadine?
    • MECHANISM: H1 blocker (2nd generation)
    • CLINICAL USES: Allergy.
    • TOXICITY: Far less sedating than 1st generation because of decreased entry into CNS.
  7. What is the MOA, use and side effects of Fexofenadine?
    • MECHANISM: H1 blocker (2nd generation)
    • CLINICAL USES: Allergy.
    • TOXICITY: Far less sedating than 1st generation because of decreased entry into CNS.
  8. What is the MOA, use and side effects of Desloratidine?
    • MECHANISM: H1 blocker (2nd generation)
    • CLINICAL USES: Allergy.
    • TOXICITY: Far less sedating than 1st generation because of decreased entry into CNS.
  9. What is the MOA, use and side effects of Cetirizine?
    • MECHANISM: H1 blocker (2nd generation)
    • CLINICAL USES: Allergy.
    • TOXICITY: Far less sedating than 1st generation because of decreased entry into CNS.
  10. What is the MOA and use of Guaifenesin?
    Expectorant—thins respiratory secretions; does not suppress cough reflex.
  11. This drug is an expectorant—thins respiratory secretion.
    Guaifenesin
  12. What the MOA and use of N-acetylcysteine?
    • Mucolytic—can loosen mucous plugs in CF patients
    • Also used as an antidote for acetaminophen overdose.
  13. This drug can loosen mucous plugs in CF patients.
    N-acetylcysteine
  14. This drug is used as an antidote for acetaminophen overdose.
    N-acetylcysteine
  15. What is the MOA, use and side effects of Dextromethorphan?
    • MOA: Antagonizes NMDA (N-methyl-d-aspartate) glutamate receptors. Synthetic codeine analog. Has mild opioid effect when used in excess.
    • USE: Cough reliever.
  16. Treatmet of overdose of Dextromethorphan.
    Naloxone can be given for overdose. Mild abuse potential.
  17. This respiratory drug antagonizes NMDA (N-methyl-d-aspartate) glutamate receptors.
    Dextromethorphan
  18. This respiratory drug is a synthetic codeine analog.
    Dextromethorphan
  19. What is the MOA, use and side effects of Pseudoephedrine? phenylephrine
    • MECHANISM: Sympathomimetic a-agonistic nasal decongestants.
    • CLINICAL USE: Reduce hyperemia, edema, and nasal congestion; open obstructed eustachian tubes. Pseudoephedrine also illicitly used to make methamphetamine.
    • TOXICITY: Hypertension. Can also cause CNS stimulation/anxiety (pseudoephedrine).
  20. What is the MOA, use and side effects of Phenylephrine?
    • MECHANISM: Sympathomimetic a-agonistic nasal decongestants.
    • CLINICAL USE: Reduce hyperemia, edema, and nasal congestion; open obstructed eustachian tubes.
    • TOXICITY: Hypertension. Can also cause CNS stimulation/anxiety (pseudoephedrine).

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