Immunogenicity of Biopharmaceuticals
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types of lymphocytes
- B cell
- t cell
- natural killer cells
what is clonal selection?
when a single progenitor cells gives wrist to a large # of lymphocytes with different antigen receptors. If the receptors bind to self antigens, they are destroyed. The rest mature into inactive lymphocytes
what is immunogenicity?
the ability of a substance to provoke an immune response.
ways to reduce immunogenicity for biopharmaceuticals
- optimize the structure (remove epitope)
- change from animal to human
- improve purity
- add barriers between biopharmaceuticals and immune system
manipulation of the immune system to treat cancer
what is an antagonist (antagonism)
prevents binging, neutralizes
crosslink receptors to exert effect
complement dependent cytotoxicity
antibody -dependent cellular cytotoxicity
when an antibody marks a pathogen for ingestion and destruction by a phagocyte
what happens if there are bacteria in extracellular space?
antibody opsonization--> ingestion by macrophage
what happens if there are bacterial toxins?
neutralization by antibodies --> ingestion by macrophage
what happens is there is a bacteria in the plasma?
Complement acitvation --> lysis and ingestion
What would you like to do?
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