Describe the effect of NSAIDs on the kidney
Prostaglandins are synthesised in the kidney. These are involved in renal blood flow and excretion of salt and water via their vasodilatory actions. NSAIDs inhibit the production of prostaglandins which impairs renal blood flow. In healthy well hydrated animals this is of little consequence but it can cause acute renal failure in conditions which depend on protective PGs e.g. if animals have a low circulating volume.