FA Immuno 1

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Author:
Neda317
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293370
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FA Immuno 1
Updated:
2015-01-20 23:31:42
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immuno
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FA
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  1. paracortex is not well developed in pts with
    digeorge syndrome
  2. Head and neck drains to ___ LN
    Cervical LN
  3. Lungs drain to ____ LN
    Hilar LN
  4. Trachea and esophagus drain to ___ LN
    Mediastinal LN
  5. Upper limb, breast, skin above umbilicus drain in ___ LN
    Axillary LN
  6. Liver, stomach, spleen, pancreas, upperduodenum drain in ___ LN
    Celiac LN
  7. Lower duodenum, jejunum, ileum, colon tosplenic flexure drain in ___ LN
    Superior mesenteric LN
  8. Colon from splenic flexure to upper rectum drain in ___ LN
    Inferior mesenteric LN
  9. Lower rectum to anal canal (above pectinateline), bladder, vagina (middle third), prostate drain in ___ LN
    Internal iliac LN
  10. Testes, ovaries, kidneys, uterus drain in ___ LN
    Para-aortic LN
  11. Anal canal (below pectinate line), skin belowumbilicus (except popliteal territory) drain in ___ LN
    Superficial inguinal LN
  12. Dorsolateral foot, posterior calf drain in ___ LN
    Popliteal LN
  13. Right lymphatic duct—drains
    right side of body above diaphragm
  14. Thoracic duct—drains
    everything else into junction of left subclavian and internal jugular veins.
  15. encapsulated organisms
    • SHiNE SKiS):
    • Streptococcus pneumoniaeƒƒ
    • Haemophilus influenzae type Bƒƒ
    • Neisseria meningitidisƒƒ
    • Escherichia coliƒƒ
    • Salmonella spp.ƒƒ
    • Klebsiella pneumoniae
    • ƒƒGroup B Streptococci
  16. Postsplenectomy:
    • ƒƒHowell-Jolly bodies (nuclear remnants)ƒƒ
    • Target cellsƒƒ
    • Thrombocytosis
  17. Innate immunity components
    • Neutrophils,
    • macrophages,
    • monocytes,
    • dendritic cells,
    • NK cells (lymphoid origin),
    • complement
  18. Innate immunity resistance
    Germline encodedResistance persists through generations, doesnot change within an organism’s lifetime
  19. Innate immunity response to pathogen
    • Nonspecific
    • Occurs rapidly (minutes to hours)
  20. Innate immunity physical barrier
    Epithelial tight junctions, mucus
  21. Innate immunity secreted protein
    Lysozyme, complement, CRP, defensins
  22. Innate immunity KEY FEATURES IN PATHOGEN RECOGNITION
    Toll-like receptors (TLRs): pattern recognitionreceptors that recognize pathogen-associatedmolecular patterns (PAMPs). Examples ofPAMPs include LPS (gram-negative bacteria),flagellin (bacteria), ssRNA (viruses)
  23. Adaptive immunity components
    T cells, B cells, circulating antibodies
  24. Adaptive immunity RESISTANCE
    • Variation through V(D)J recombination duringlymphocyte development
    • Microbial resistance not heritable
  25. Adaptive immunity RESPONSE TO PATHOGENS
    Highly specific, refined over timeDevelops over long periods; memory response is faster and more robust
  26. Adaptive immunity PHYSICAL BARRIER S
    none
  27. Adaptive immunity SECRETED PROTE INS
    Immunoglobulins
  28. Adaptive immunity KEY FEATURE S IN PATHOGEN RECOGN ITION
    Memory cells: activated B and T cells;subsequent exposure to a previouslyencountered antigen Ž stronger, quicker immune response
  29. MHC I binding
    TCR and CD8
  30. MHC II binding
    TCR and CD4
  31. MHC I Expression
    • Expressed on all nucleated cells 
    • Not expressed on RBCs
  32. MHC II expression
    Expressed only on APCs
  33. MHC I func
    Present endogenously synthesized antigens(e.g., viral) to CD8+ cytotoxic T cells
  34. MHC II func
    Present exogenously synthesized proteins (e.g.,bacterial proteins, viral capsid proteins) to T-helper cells
  35. MHC I ANTIGEN LOADING
    Antigen peptides loaded onto MHC I in RER after delivery via TAP peptide transporter
  36. MHC II ANTIGEN LOADING
    Antigen loaded following release of invariant chain in an acidified endosome
  37. MHC I MODE OF TRANSPORT TO CELL SURFACE
    β2-microglobulin
  38. MHC II MODE OF TRANSPORT TO CELL SURFACE
    unknown
  39. HLA subtypes associated with diseases: A3
    hemochromatosis
  40. HLA subtypes associated with diseases: B27
    • MN: PAIR:
    • psoriasis, ankylosing spondylitis, inflammatory bowel disease, reiter's syndrome
  41. HLA subtypes associated with diseases: B8
    Grave's disease
  42. HLA subtypes associated with diseases: DR2
    multiple sclerosis, hay fever, SLE, goodpasture's
  43. HLA subtypes associated with diseases:DR3
    Diabetes mellitus type 1
  44. HLA subtypes associated with diseases: DR4
    rheumatoid arthritis, DM type I
  45. HLA subtypes associated with diseases: DR5
    PERNICIOUS ANEMIA leading to B12 deficiency, hashimoto's thyroiditis
  46. HLA subtypes associated with diseases: DR7
    steroid-responsive nephrotic syndrome
  47. HLA subtypes associated with diseases: DQ2/DQ8
    Celiac disease
  48. Natural killer cells Activity enhanced by
    IL-2, IL-12, IFN-β, and IFN-α.
  49. POSITIVE (UPREGULATED )
    Serum amyloid A
    Prolonged elevation can lead to amyloidosis
  50. POSITIVE (UPREGULATED )
    C-reactive protein
    Opsonin; fixes complement and facilitates phagocytosis.Measured clinically as a sign of ongoing inflammation.
  51. POSITIVE (UPREGULATED )
    Ferritin
    Binds and sequesters iron to inhibit microbial iron scavenging
  52. POSITIVE (UPREGULATED )
    Fibrinogen
    Coagulation factor; promotes endothelial repair; correlates with ESR.
  53. POSITIVE (UPREGULATED )
    Hepcidin
    Prevents release of iron bound by ferritin -->Ž anemia of chronic disease
  54. NEGATIVE (DOWN-REGULATED )
    Albumin
    Reduction conserves amino acids for positive reactants.
  55. NEGATIVE (DOWN-REGULATED )
    Transferrin
    Internalized by macrophages to sequester iron.
  56. C1 esterase inhibitor deficiency
    Causes hereditary angioedema. ACE inhibitors are contraindicated.
  57. C3 deficiency
    Increases risk of severe, recurrent pyogenic sinus and respiratory tract infections;  susceptibility to type III hypersensitivity reactions.
  58. C5–C9 deficiencies
    Increase susceptibility to recurrent Neisseria bacteremia
  59. DAF (GPI anchoredenzyme) deficiency
    Causes complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria.
  60. cytokines SECRETED BY MACROPHAGES
    • IL-1
    • IL-6
    • IL-8
    • IL-12
    • TNF-alpha
  61. cytokines SECRETED BY T CELLS
    • IL-2
    • IL-3
  62. cytokines SECRETED BY Th1 CELLS
    INF-gama
  63. cytokines SECRETED BY Th2 CELLS
    • IL-4
    • IL-5
    • IL-10
  64. What cytokine works the same as IL-10 which is an inhibitory cytokine (inhibiting inflammation) ? 
    TGF-beta 

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