FA Immuno 2

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  1. IL-1 func:
    An endogenous pyrogen, also called osteoclast-activating factor. Causes fever,acute inflammation. Activates endotheliumto express adhesion molecules; induces chemokine secretion to recruit leukocytes.
  2. IL-6 func
    An endogenous pyrogen. Also secreted by Th2 cells. Causes fever and stimulates production of acute-phase proteins. pro-inflammatory. 
  3. IL-8 func:
    Major chemotactic factor for neutrophils.
  4. IL-12 func:
    Induces differentiation of T cells into Th1 cells.Activates NK cells. Also secreted by B cells.
  5. TNF-a func:
    Mediates septic shock. Activates endothelium.Causes leukocyte recruitment, vascular leak.
  6. IL-2 func:
    Stimulates growth of helper, cytotoxic, and regulatory T cells.
  7. IL-3 func:
    Supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF.
  8. Interferon-γ func:
    • Has antiviral and antitumor properties.Activates NK cells to kill virus-infected cells,Increases MHC expression and antigen
    • presentation in all cells.
  9. IL-4 func:
    Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.
  10. IL-5 func:
    Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates the growth and differentiation of eosinophils.
  11. IL-10 func:
    Modulates inflammatory response. Inhibits actions of activated T cells and Th1. Also secreted by regulatory T cells.
  12. Interferon alpha and beta func:
    • A part of innate host defense against both RNA and DNA viruses. Interferons are glycoproteins synthesized by viral-infected cells that act locally on uninfected cells,“priming them” for viral defense. When avirus infects “primed” cells, viral dsRNA activates:ƒƒ
    • -RNAase L Ž--> degradation of viral/hostmRNA.ƒƒ
    • -Protein kinase -->Ž inhibition of viral/hostprotein synthesis.
    • Essentially results in apoptosis, therebyinterrupting viral amplification.
  13. T cell Cell surface proteins
    • TCR (binds antigen-MHC complex)
    • CD3 (associated with TCR for signaltransduction)
    • CD28 (binds B7 on APC)
  14. helper T cell Cell surface proteins
    CD4, CD40 ligand
  15. cytotoxic T cell Cell surface proteins
  16. B cell Cell surface proteins
    Ig (binds antigen)CD19, CD20, CD21 (receptor for EBV), CD40MHC II, B7
  17. macrophages Cell surface proteins
    CD14, CD40MHC II, B7Fc and C3b receptors (enhanced phagocytosis)
  18. NK cells Cell surface proteins
    CD16 (binds Fc of IgG), CD56 (unique markerfor NK)
  19. Anergy
    Self-reactive T cells become nonreactive without costimulatory molecule. B cells also become anergic, but tolerance is less complete than in T cells.
  20. After exposure to _____ patients are given preformed antibodies (passive)
    • "To Be Healed Rapidly”
    • After exposure to Tetanus toxin, Botulinum toxin, HBV, or Rabies virus, patients are given preformed antibodies (passive)
  21. Live attenuated vaccine are
    Measles, mumps,rubella, polio (Sabin),influenza (intranasal),varicella, yellow fever.
  22. Inactivated or killed vaccine are
    Cholera, hepatitis A,polio (Salk), influenza(injection), rabies.
  23. Live attenuated vaccine induces
    induces a cellular response.
  24. Inactivated or killed vaccine induce
    Humoral immunity induced
  25. Arthus reaction
    reaction—a local subacute antibodymediated hypersensitivity (type III) reaction. Intradermal injection of antigen induces antibodies, which form antigen-antibody complexes in the skin. Characterized by edema, necrosis, and activation of complement.
  26. Serum sickness
    an immune complex disease (type III) in which antibodies to the foreign proteins are produced (takes 5 days).Immune complexes form and are deposited in membranes, where they fix complement (leads to tissue damage). More common than Arthus reaction.
  27. Anaphylaxis (e.g., bee sting, some food/drugallergies)
    Type I Hypersensitivity disorders
  28. Allergic and atopic disorders (e.g., rhinitis, hayfever, eczema, hives, asthma)
    Type I Hypersensitivity disorders
  29. Autoimmune hemolytic anemia HS?
    Type II Hypersensitivity disorders
  30. HS: Pernicious anemia
    Type II Hypersensitivity disorders
  31. HS Idiopathic thrombocytopenic purpura
    Type II Hypersensitivity disorders
  32. HS Erythroblastosis fetalis
    Type II Hypersensitivity disorders
  33. HS Acute hemolytic transfusion reactions
    Type II Hypersensitivity disorders
  34. HS Rheumatic fever
    Type II Hypersensitivity disorders
  35. HS Goodpasture syndrome
    Type II Hypersensitivity disorders
  36. HS Bullous pemphigoid
    Type II Hypersensitivity disorders
  37. HS  Pemphigus vulgaris
    Type II Hypersensitivity disorders
  38. HS Polyarteritis nodosa
    Type III Hypersensitivity disorders
  39. HS Poststreptococcal glomerulonephritis
    Type III Hypersensitivity disorders
  40. HS Serum sickness
    Type III Hypersensitivity disorders
  41. HS Arthus reaction (e.g., swelling and inflammation following tetanus vaccine)
    Type III Hypersensitivity disorders
  42. HS SLE
    Type III Hypersensitivity disorders
  43. HS Multiple sclerosis
    Type IV Hypersensitivity disorders
  44. HS Guillain-Barré syndrome
    Type IV Hypersensitivity disorders
  45. HS Graft-versus-host disease
    Type IV Hypersensitivity disorders
  46. HS PPD (test for M. tuberculosis)
    Type IV Hypersensitivity disorders
  47. HS Contact dermatitis (e.g., poison ivy, nickelallergy)
    Type IV Hypersensitivity disorders
  48. Myasthenia gravis AUTO ANTIBODY
    Anti-ACh receptor
  49. Goodpasture syndrome ab
    Anti-basement membrane
  50. SLE, antiphospholipid syndrome ab
    Anti-cardiolipin, lupus anticoagulant
  51. Limited scleroderma (CREST syndrome) ab
  52. Pemphigus vulgaris ab
  53. SLE ab
    Anti-dsDNA, anti-Smith
  54. Type 1 diabetes mellitus ab
    Anti-glutamate decarboxylase
  55. Bullous pemphigoid ab
  56. Drug-induced lupus ab
  57. Polymyositis, dermatomyositis ab
    Anti-Jo-1, anti-SRP, anti-Mi-2
  58. Hashimoto thyroiditis ab
    Antimicrosomal, antithyroglobulin
  59. 1° biliary cirrhosis ab
  60. SLE, nonspecific ab
    Antinuclear antibodies
  61. Scleroderma (diffuse) ab
    Anti-Scl-70 (anti-DNA topoisomerase I)
  62. Autoimmune hepatitis ab
    Anti-smooth muscle
  63. Sjögren syndrome ab
    Anti-SSA, anti-SSB (anti-Ro, anti-La)
  64. Graves disease ab
    Anti-TSH receptor
  65. Mixed connective tissue disease ab
    Anti-U1 RNP (ribonucleoprotein)
  66. Granulomatosis with polyangiitis (Wegener) ab
    c-ANCA (PR3-ANCA)
  67. Celiac disease ab
    IgA antiendomysial, IgA anti-tissue transglutaminase
  68. Microscopic polyangiitis, Churg-Strauss syndrome ab
  69. Rheumatoid arthritis ab
    Rheumatoid factor (antibody, most commonlyIgM, specific to IgG Fc region), anti-CCP
  70. if no B-cell what bacterial infection?
    • Bact: Encapsulated:(SHiNE SKiS)
    • Streptococcus pneumoniae, Haemophilusinfluenzae type B,
    • Neisseria meningitidis, Escherichia coli, Salmonella, Klebsiellapneumoniae, group B
  71. if no GRANULOCYTE  what bacterial infection?
    • Staphylococcus,
    • Burkholderia cepacia,
    • Serratia,
    • Nocardia
  72. if no complement what bacterial infections?
    Neisseria (nomembrane attackcomplex)
  73. if no T-cell what bacterial infection?
  74. if no T-cell what viral infection?
    CMV, EBV, JCV, VZVchronic infectionwith respiratory/GIviruses
  75. if no B-cell what viral infection?
    Enteroviral encephalitis, poliovirus (live vaccine contraindicated)
  76. If no T-cells what fungal/parasites infections?
    Candida, PCP
  77. If no B-cells what fungal/parasites infections?
    GI giardiasis (no IgA)
  78. If no GRANULOCYTE what fungal/parasites infections?
    Candida, Aspergillus
  79. SLE most specific ab?
    Anti dsDNA and anti-smith 
  80. which cytokine is involved w acute phase reaction? 
    IL-6 made by t-lymphocyte 
Card Set:
FA Immuno 2
2015-01-21 04:41:47

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