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NADPH used in rxs
nicotinamides and flavin nucleotides are activated electron carriers, but only NADPH can be used in anabolic (energy-requiring) reactions. It is derived from vitamin B3 (niacin). Its uses in the body include the building of fatty acids and steroids, generation of the respiratory burst in WBCs, and the recycling (reducing) of glutathione in RBCs. Glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the oxidative portion of the pentose phosphate pathway, is the enzyme that generates NADPH.
disulfiram rx drugs
ke reaction after alcohol consumption, which include nausea, vomiting, headache, flushing, and tachycardia. First-generation sulfonylureas, and chlorpropamide in particular, can cause a disulfiram-like reaction when taken with ethanol. Other medications that are known to cause disulfiram-like reactions include metronidazole, procarbazine, and some cephalosporins.
specific neural tracts in the brain that are interrupted by chlorpromazine. Inte rruption of what neural tract is responsible for the amenorrhea observed in the studied chimpanzees?ct
Knowing both that the typical antipsychotics act as D2 receptor antagonists in the tuberoinfundibular tract causes hyperprolactinemia and that hyperprolactinemia causes abnormal menstruation and/or amenorrhea leads to selecting the tuberoinfundibular tract as the interrupted tract leading to prolactin disinhibition by D2 receptor antagonism.
Fibrates (gemfibrozil,..) moa
stimulates lipoprotein lipase by activation of the PPAR-α protein.
Adenosine is extremely useful in abolishing atrioventricular (AV) nodal arrhythmias when given in high-dose intravenous boluses. Adenosine works by hyperpolarizing AV node tissue by increasing the conductance of potassium and by reducing calcium current. As a result, the conduction through the AV node is markedly reduced. In addition to this, adenosine's extremely short duration of action (15 seconds) limits the occurrence of its toxicities (ie, hypotension, flushing, chest pain, and dyspnea).
Which CCB has the same effect as beta-1 blocker? to decrease contractility
- Diltiazem is a non-dihydropyridine calcium channel blocker, but is not as effective as verapamil in reducing the rate and contractility of the heart.