LAB Animal Research
Card Set Information
LAB Animal Research
Basic Regulatory Information For Animal Research Laboratories.
Who over sees the care and use of animals?
What guidelines do the IACUC use?
AWR and PHS
If fluids are restricted how often must you way the animal?
At least once a week (twice for rodents)
What is a Micro and Macro environment?
Macro - Room
Micro - Kennel/Cage
What is Thigomotactic, and what species prefers it?
Mice: They prefer more wall space than floor space
What is the lighting lux and noise dB max?
325lux and 85dB
At what temp will food start detreriate?
why is cedar shavings looked down upon?
emit aromatic hydocarbons that effect liver enzymes
What two zoonotic diseases are from non-human primates?
Filovirus and mcobacterial
What intra-species disease is carried in rabbits?
Subclinical infections in rodents are? (5)
Sendai virus, kilham rat virus, mouse hep virus, lymohocytic choriomeningitis virus, mycoplasma pulmonis
Animal Room Doors measurements are...
~42in W and ~84in H
Humidity levels should be where?
30-70% with a 5% variation
Lighting should be on what system in animal rooms?
time-contolled diurinal lighting cycle
What members are necessary fro the IACUC?
Veterinarian, public member, and scientist
IACUC acronym stands fro what?
Institutional Animal Care Use Committee
Animals adapt to extreme temps by what three methods?
Physical, morphological, behavorial
What kind of cage do rodents like?
Solid bottom with bedding
How many air changes per hour in an animal room?
What animal helped determine illumination levels?
What is susceptiable to animals due to high room illumination levels?
When should bedding changes not be performed?
Pre- and Postpartum (child birth)
How often should solid bottoms and accessories be sanitized?
once a week for the cage and once every two weeks for accessories
What is the effective temp range for a quality sanitation?
What animal produces large amounts of proteins and minerals in their urine?
Which type of rodent has high levels of homozygosity?
Subclincial diseases are most common in what kind of rodents?
What are corridor widths in facility?
What should the floors be made of?
What type of walls help eliminate noise?
A Class-A dealer is....
raise and sell purpose-bred species
A class-B dealer is...
provide random source animals
How must dogs (and cats) be housed?
Not outdoors, 45-85F, 6in higher than dogs tallest head [(L+6)^2/144=floor space]
What is the temp range for the housing of guinea pigs and hamsters?
What is the temp range for housing rabbits?
What is the temp range for primates?
When air transporting primates, what must the container label say?
Live Animals: Wild Animals
USDA and IACUC inspect how often?
USDA, annually; IACUC, semiannually
USDA tags do not have which of the following: USDA letter, state identifier, id number, date of birth.
date of birth
How do you id pus under 16 weeks?
How long must pass before a USDA number can be reused?
What is the earliest a vet can do a health examination before transportation?
How long must an animal wait to be used in research when obtained by random source?
How often must dogs be exercised, or reviewed to exercise if exempted previously?
Once a day; 30 days
Minimal height for a guinea pigs cage is...
Interior height of hamster cages must be at least how many inches?
how long can temps exceed ranges before a deviation accurs?
What is the minimum height for a rabbits cage?
Rabbits sanitations are how many days before the next?
What is the max amount of rabbits in one inclosure while transporting?
What does APHIS stand for?
animal and Plant Health Inspection Service
How many principles are there for animal research?
PHS policy mandates animal care programs to be in accordance with what three laws?
AWA, the "Guide", and AVMA
How often must an assurance report be done for the "Guide"?
Every 5 years
What is a category 1 institute?
Accredited by the AAALAC and all facilities evaluated every 6 months
What is the difference from a category 2 institute from a category 1?
Evaluated by the institute, and most recent report submitted to assurance.
How many members at lest does the IACUC need?
5 members. One DVM, one scientist, and one public member
What does the IACUC consider an animal facility?
The holding of animals >24 hours
Who shall the IACUC notice for approved/disapproved projects?
the investigators and the institution
If the IACUC suspends a project that was already approved who do they contact?
IO and IACUC will review then send to OLAW
How long must records be kept?
How often must IACUC report to OLAW
At least every 12 months?
What agencies does the PHS consist of?
Substance abuse and mental health services, health resources and services, Indian health services, NIH, and CDC
When exceptions to laws and guides, who must approve?
How often must approved projects be reviewed?
Who bears ultimate responsibility for non clinical lab studies?
Who is responsible for the overall conduct of a nonclinic study?
What records are exempt from FDA inspections?
How long must raw data, records, and documentations be stored?
10 years minimum
Who is authorized to inspect a facility and records to be maintained?
FDA and EPA