Card Set Information
What are the products of pro-opiomelanocortin?
- Melanocyte stimulating hormone
(opoid peptide- mu, delta, kappa receptors)
What is somatomedin C?
Refered to as
insulin-like growth factor
which is released in response to
With which maternal blood types does erythroblastosis fetalis and hemolytic disease of the newborn occur?
Maternal blood types
A and B
: the antibodies (Anti-A and -B) are of the
cross the placenta.
In maternal blood type
, the antibodies are primarily
and can cross the placenta to cause
and can cross the placenta to cause hemolysis.
At what week of gestation are neural crest cells present in the rectum?
At what week of gestation are neural crest cells present in the colon?
What genetic mutation is Hirshsprung disease associated with?
Failure of neural crest cell migration
What causes orotic aciduria?
Can't convert orotic acid to Uridine monophosphate (UMP)
What is the pathology seen below?
Horse shoe kidney
What causes a horseshoe kidney?
Results from fusion of the inferior poles of both kidneys.
As the kidneys ascend from the pelvis during fetal development, horseshoe kidneys get trapped under
inferior mesenteric artery.
What does the medullary cord contain?
B cells, plasma cells
What does the medullary sinuses contain?
Reticular cells and macrophages
What causes Lynch syndrome?
Mutation of DNA mismatch repair genes
Mutation in the genes
MSH2 and MLH1
which code for components of the human
MutS and MutL
What are the effects of Radiation therapy?
Causes apoptosis of tumors via
free radical formation
What is the function of microglia?
(derived from monocytes) move into area of ischemic infarct 3-5 days and they phagocytize fragments of neurons, myelin and debris
HIGH LIPID STAINING