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In clinical study design; Compare and contrast the concepts of:
-Internal and external validity
-What are the potential sources of bias in clinical trials?
-Which strategies to eliminate or control for bias?
Outline the hierarchy of evidence generated by various study designs??
Compare and contrast the advantages & disadvantages of various study designs: Prospective
Randomized controlled clinical trials
Delineate the difference between:
Parallel & crossover study designs.
Select from various biostatistical measures to appropriately compare groups or their assessmentsfrom various study designs and use their findings/output to interpret results
- The different Test eg Chi square ANOVA etc
Define and evaluate odds, odds ratio, risk/incidence rate, risk ratio/relative risks (RRs), and other risk estimates. Compute and evaluate number neededto treat and number needed to harm. Define andcalculate terms such as point and period prevalence,incidence rate, prevalence rate, absolute risk difference, and RR difference
Define and calculate terms such as:
-Positive predictive value
-Negative predictive value
-Positive likelihood ratio and
-Negative likelihood ratio
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