BIBC 120 Proteins

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Author:
andrewlee22087
ID:
294861
Filename:
BIBC 120 Proteins
Updated:
2015-02-04 17:06:05
Tags:
nutrition
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Description:
nutrition
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  1. How are digestive proteases secreted and how are they activated?
    • They are secreted as proenzymes, or zymogens
    • hydrolysis from the N-terminus activates the protease
  2. Pepsin
    site of action
    proenzyme secreted by
    site of action on substrate protein
    • stomach
    • chief cells in gastric pits
    • endopeptidase
  3. Trypsin
    site of action
    proenzyme secreted by
    site of action on substrate protein
    • Small intestine
    • pancreas
    • endopeptidase
  4. Chymotrypsin
    site of action
    proenzyme secreted by
    site of action on substrate protein
    • small intestine
    • pancreas
    • endopeptidase
  5. Carboxypeptidase A
    site of action
    proenzyme secreted by
    site of action on substrate protein
    • small intestine
    • pancreas
    • exopeptidase
  6. Carboxypeptidase B
    site of action
    proenzyme secreted by
    site of action on substrate protein
    • small intestine
    • pancreas
    • exopeptidase
  7. Different protein transporters for different amino acids are based on?
    R-groups
  8. What does tTG do?
    tTG binds to gliadin in the brush border to convert glutamine to glutamate. The reanimated peptides bind to HLA-DQ2 to stimulate the production of anti-tTG antibody, resulting in an attack of the brush border.

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