Mb230 3-4

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studysuccess
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294922
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Mb230 3-4
Updated:
2015-02-17 03:16:16
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Mb230
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Mb230 3-4
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Mb230 Destructive immune response
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  1. 3 types of destructive immune responses
    • 1) autoimmunity
    • 2) hypersensitivity
    • 3) Immunodeficiency
  2. Define autoimmunity
    Activation of self-reactive T and B cells which result in tissue damage.
  3. Type I Hypersensitivity causes what 2 excessive responses to Ag's?
    • *IgE-mediated release of histamines causing allergies and localized/ systemic anaphylaxis (release of histamine, leukotrienes etc.)
    • &
    • -Allergies and systemic/locallized anaphylaxix
  4. *-IgE-mediated (release of histamine, leukotrienes etc.) &
    -Allergies and systemic/locallized anaphylaxis 
    are both what type of destructive immune response?
    Type I Hypersensitivity.
  5. Type II hypersensitivity causes what destructive responses to Ag's
    • *IgG/IgM & complement causes cytolytic reactions &
    • -blood transfusion/erythroblastosis fetalis are both what type of destructive immune response
  6. -IgG/IgM+ complement cytolytic reactions &
    -blood transfusion/erythroblastosis fetalis are both what type of destructive immune response
    Type II hypersensitivity.
  7. Type IV hypersensitivity causes what 2 destructive responses to Ag's
    *Delayed CD*+ T cell-mediated immune reactions

    • and CTL (cytotoxic lymphocytes) responses &
    • -blood transfusion/erythroblastosis fetalis are both part of what destructive immune response
  8. -Delayed, cell-mediated immune reactions; CD4 T cells=TH (helper T cells) and CD8 T cells=CTL (cytotoxic lymphocytes) responses &
    -blood transfusion/erythroblastosis fetalis are both part of what destructive immune response
    Type IV hypersensitivity
  9. Type III hypersensitivity causes what 2 destructive responses to Ag's?
    • -immune complex formation (IgG) due to excessive amounts of soluble Ag &
    • -Localized excesive inflammatory responses (vasculitisblood vessels, Glomerulonephritiskidney, arthritisjoints, systemic lupus erythematosusskin)
  10. -immune complex formation (IgG) due to excessive amounts of soluble Ag &
    -Localized excesive inflammatory responses (vasculitisblood vessels, Glomerulonephritiskidney, arthritisjoints, systemic lupus erythematosusskin)
    Type III hypersensitivity
  11. An excessive response to appropriate Ag is
    Hypersensitivity
  12. What does Chemotherapy mean
    treatment or therapy with chenicals
  13. Antibacterial
    antimicrobials that interfere with or destroy microbial cells
  14. antibiotic
    • chemicals produced by a microorganism in order to inhibit or kill another microorganism
    • (used for bacteria, fungi, protozoal)
  15. Natural antibiotic
    • chemical produced by nature (not microorgism) to inhibit or kill another microorganism
    •  (used for bacteria, virus, fungi, protozoal)
  16. Semi-synthetic
    natural chemical modified before use (used for bacteria, virus, fungi, protozoal)
  17. synthetic
    created in lab to inhibit or kill another microorganism (used for bacteria, virus, fungi)
  18. Cidal means
    kill organism
  19. Static means
    inhibit organism growth
  20. selective toxic methods to effect bacteria include through
    -inhibition of cell wall synthesis by targeting pepdidoglycan synthesis.
    -inhibition of protein synthesis through targetting ribosomes.
    -inhibition of nucleic acid replication.
    -injury to PM stability
    -Inhibition of synthesis of essential metabolites.
    Antibacterial drugs.
  21. Defects in one or more components of the immune system are either
    congenital or acquired
  22. What 4 areas do antibacterials target
    • 1) cell wall
    • 2) PM
    • 3) protein synthesis
    • 4) nucleic acid
    • 5) essential metabolic pathways
  23. How does sulfanilamide/protosil work
    stops synthesis of folic acid in prokaryotes (effective against Gram-negative and Gram-positive)
  24. what does penicillin target
    • stops synthesis of peptidoglycan. 
    • -was made in fungi (penicillium notatum). Bacteria w/peniccinase are resistant
  25. what do broad-spectrum antibiotics target
    stops protein synthesis by interfering with amino acid and codon matching.
  26. Development of a microbial population which cannot be killed by the drug is known as
    drug resistance
  27. 3 ways microbes destroy or bypass the drug?
    • 1) change or destroy antimicrobial
    • 2) transport them out of cell
    • 3) change the structure of a binding site.
  28. 2 ways microbes develop resistance to antibiotics
    mutations and gene transfer from 1 microbacterium to another.

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