autonomic agents

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  1. what is innervated by the Autonomic NS? Sensory Comp?
    • smooth muscle, cardiac muscles , glands
    • 2 neuron PW. originate in CNS, first nerve is myelinated, second cell body is a ganglia- second axon is generally unmyelinated
    • Symp and para make up ANS
    • slower than somatic
    • sensory comp- interoceptors- mechano/chemo
  2. Parasympathetic NS role
    • control at rest
    • decrease HR and BP
    • food seeking
    • digestion
    • energy storage
    • NEVER discharges as a system but individual organs
    • Required for LIFE
    • Hypothal and reticular system control

  3. Sympathetic NS role
    • dormant unless stimulated, emergency
    • responds as a SINGLE system, not required for life
    • HR BP increase
    • skin and viscera vasoconstrict
    • blood shifts to muscle and brain
    • bronchodilation
    • pupil dilate
    • increase in blood glucose and metabolic rate
    • inhibits gi and decrease salivation
  4. Somatic Nervous syetm
    • bundle of myelinated nerves run directly from spinal cord to stirated muscles. 
    • Makes up peripheral Nervous System along with the autonomic
  5. parasymp respond as a system?
  6. sympathetic respond as a system?
  7. para preganglionic fibers origin?
    ganglia location
    • cranial sacral
    • closer to effector organ- longer preganglionic fibers
  8. sympathetic preganglionic fibers origin?
    ganglia location?
    • thoracolumbar 
    • close to sc- short preganglionic fiber
  9. parasympathetic neccessary for life?
    directed or divergent?
    • yes
    • directed
  10. sympathetic neccessary for life?
    directed or divergent?
    • no
    • divergent
  11. What is the NTs of the ANS?
    Where is each used?
    • Both para and sym use ACh from preganglionic to ganglia
    • Para Post uses Ach
    • Sym Post use NE or Epi (if adrenal)
  12. Receptors of ANS?
    • Sympathetic uses Nicotinic first then Adrenergic Receptors- accept Epi/ NE
    • Para- Cholinergic receptors: First Nicotinic (ACh) and  second Muscarinic (ACh)
  13. general response to stimulation of receptor for Beta 1
    • stimulate heart and kidney. Positive inotrope- release of renin and renal blood flow
    • Dopamine and dobutamine- Severe CHF stress testing
    • S/E- tachy
  14. general response to stimulation of receptor beta 2
    • bronchodilation and uterine relaxation
    • asthma- copd- delay premature labor with terbutaline, priapism
    • S/E- beta 1 cross rxt- tachy, muscle tremor, nervous
    • albuterol
  15. alpha 1 agonist response
    • sm contraction
    • norepi
    • mydriasis
  16. general response to stimulation of receptor alpha 1 antagonist
    • vasodilation- prostate and bladder neck relaxhtn, BPH
    • S/E- syncope, orthostatic htn, dizziness, reflex tach
    • prazosin, terazosin, doaxasin SIN
  17. general response to stimulation of receptor alpha 2
    • decrease sympathetic ns
    • htn
    • S/E dry mouth, fatigue, sedation, 
    • clonidine and methyldopa
  18. general response to stimulation of receptor to muscarinic
    • cardiac muscle- decrease sa and av node
    • smooth muscle contract of bladder and bronchial tissue
    • bronchoconstirction
    • increases secretory gland activity increase saliva and GI
    • SLUDD-C
  19. Nicontinic Receptor channel type
    Muscarinic channel type
    • ion- excite
    • Metabotropic- excite OR inhibits
  20. where would one target drugs to be most effective?
    where would it be least effective?
    • at the effector organ receptor
    • at the axon
  21. Adrenal Gland- how is it activated?
    What system controls it?
    NT released?
    Where does NT Act?
    Where is inactivation?
    • via ACh
    • sympathetic NS
    • Epi
    • on adrenergic receptors
    • metabolized by MAO/ COMT
    • IF in ECF THEN primarily reuptake by catecholamine boutons, or MAO metab
  22. what is tone?
    baroceptor reflex?
    control of peripheral resistance- sympathetically innervated! response depends on population of vasodil(beta) or vasoconstricting(alpha) receptors

    high BP activates stretch baroreceptors which leads to sympathetic inhibition and slows the heart
  23. primary control for:
    A. Blood Vessels?
    B. Heart?
    C. Pulm Smooth muscle?
    D. GI?
    E. Salivary?
    • A. Sympathetic
    • B. Para
    • C. Para
    • D. Para
    • E. Para
Card Set:
autonomic agents
2015-02-09 18:35:25
autonomic agents
autonomic agents
autonomic agents
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