The potential targets for AED’s action on the GABAergic inhibitory synapses
(a) drugs that enhance the biosynthesis of GABA (gabapentin, pregabalin, and VPA
(b) drugs that inhibit GABA degradation (vigabatrin)
(c) drugs that inhibit the reuptake of GABA (tiagabine)
(d) drugs that bind to an allosteric site on the postsynaptic GABAA receptor complex that increase chloride conduc- tance (barbiturates, BZDs,neurosteroids, FBM, TPM).