What is the bio-design process for developing a need statement? flow chart
Translate problem into need statement
Verify accuracy of need statement against problem
Confirm that need is solution independent
Validate that scope of the need is appropriate
Define need criteria and classify need
Superseding needs and related solutions
The closer a need is to addressing the fundamental aspects of a disease state, the less likely it is that the need will be displaced by an alternate need and its solution.
Categories of needs and their associated risk
Describe a heart attack and the resulting biological implications
Heart muscle deprived of oxygen and nutrients
Formation of a scar (fibrosis)
Does not function like muscle (cannot contract, cannot pump)
May lead to congestive heart failure (of not immediately deadly)
What is another name for a heart attack
What is atherosclerosis?
Atherosclerosis is a condition in which plaque builds up on the inner lining of arteries. the plaque is formed from cholesterol, fat, calcium, and other substances in the blood. A fatty streak develops inside the Intima.
This can develop into an unstable plaque with a thin fibrous cap and a fatty core.
Often, the unstable plaque evolves into a stable plaque with a thick fibrous cap.
the plaque can also remain unstable and vulnerable to rupture.
If a rupture occurs it is usually located along the margins of the plaque.
The ruptured material triggers blood clotting.
Sometimes the blood clot can grow and block the artery entirely.
Describe a coronary artery bypass graft
Vein graft: vein removed from the leg and is stitched to the aorta and coronary artery.
Internal mammary artery graft: artery relocated from the chest wall. The artery graft is stitched to the coronary artery to bypass the blockage