BME 350 Lecture 2
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What is the bio-design process for developing a need statement? flow chart
- Translate problem into need statement
- Verify accuracy of need statement against problem
- Confirm that need is solution independent
- Validate that scope of the need is appropriate
- Define need criteria and classify need
Superseding needs and related solutions
The closer a need is to addressing the fundamental aspects of a disease state, the less likely it is that the need will be displaced by an alternate need and its solution.
Categories of needs and their associated risk
Describe a heart attack and the resulting biological implications
- Heart muscle deprived of oxygen and nutrients
- Cardiomyocyte death
- Formation of a scar (fibrosis)
- Does not function like muscle (cannot contract, cannot pump)
- May lead to congestive heart failure (of not immediately deadly)
What is another name for a heart attack
What is atherosclerosis?
- Atherosclerosis is a condition in which plaque builds up on the inner lining of arteries. the plaque is formed from cholesterol, fat, calcium, and other substances in the blood. A fatty streak develops inside the Intima.
- This can develop into an unstable plaque with a thin fibrous cap and a fatty core.
- Often, the unstable plaque evolves into a stable plaque with a thick fibrous cap.
- the plaque can also remain unstable and vulnerable to rupture.
- If a rupture occurs it is usually located along the margins of the plaque.
- The ruptured material triggers blood clotting.
- Sometimes the blood clot can grow and block the artery entirely.
Describe a coronary artery bypass graft
- Vein graft: vein removed from the leg and is stitched to the aorta and coronary artery.
- Internal mammary artery graft: artery relocated from the chest wall. The artery graft is stitched to the coronary artery to bypass the blockage
What would you like to do?
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