BME 350 Lecture 2

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  1. What is the bio-design process for developing a need statement? flow chart
    • Translate problem into need statement
    • Verify accuracy of need statement against problem
    • Confirm that need is solution independent
    • Validate that scope of the need is appropriate
    • Define need criteria and classify need
  2. Superseding needs and related solutions
    The closer a need is to addressing the fundamental aspects of a disease state, the less likely it is that the need will be displaced by an alternate need and its solution.
  3. Categories of needs and their associated risk
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  4. Describe a heart attack and the resulting biological implications
    • Heart muscle deprived of oxygen and nutrients
    • Cardiomyocyte death
    • Formation of a scar (fibrosis)
    • Does not function like muscle (cannot contract, cannot pump)
    • May lead to congestive heart failure (of not immediately deadly)
  5. What is another name for a heart attack
    Myocardial Infaction
  6. What is atherosclerosis?
    • Atherosclerosis is a condition in which plaque builds up on the inner lining of arteries. the plaque is formed from cholesterol, fat, calcium, and other substances in the blood. A fatty streak develops inside the Intima.
    • This can develop into an unstable plaque with a thin fibrous cap and a fatty core.
    • Often, the unstable plaque evolves into a stable plaque with a thick fibrous cap.
    • the plaque can also remain unstable and vulnerable to rupture.
    • If a rupture occurs it is usually located along the margins of the plaque.
    • The ruptured material triggers blood clotting.
    • Sometimes the blood clot can grow and block the artery entirely.
  7. Describe a coronary artery bypass graft
    • Vein graft: vein removed from the leg and is stitched to the aorta and coronary artery.
    • Internal mammary artery graft: artery relocated from the chest wall. The artery graft is stitched to the coronary artery to bypass the blockage
Card Set:
BME 350 Lecture 2
2015-02-22 20:56:44
BME 350
BME 350
BME 350
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