3.Build on the Ideas of Others - No “buts,” only “ands”
4.Go for Quantity – Aim for 100 ideas in 60 minutes!
5.One Conversation at a Time – Let people have their say
6.Stay Focused on the Topic – Keep the discussion on target
7.Be Visual – Take advantage of your space. Use objects and toys to stimulate ideas
What was the proposed need relative to heart attacks?
A new approach to stimulate regeneration of the heart muscle in patients that have experienced a heart attack
Ideas to fulfill the proposed need:
Coronary Stent - need stent delivery catheter
Drug coated stent
Cellular cariomyoplasty - stem cells are filtered from the bone marrow removed from a patients hip. the cells are injected into the heart's damaged area. the cells embed themselves and produce proteins that signal the growth of new blood vessels and heart muscle.
Stem cell therapy for heart muscle - mouse adult stem cells are injected into the muscle of the damaged left ventricular wall of the mouse heart. Stem cells help regenerate damaged heart muscle. In addition, human adult bone marrow stem cells are injected into the tail vasculature of a rat. The stem cells induce new blood vessel formation in the damaged heart muscle and proliferation of existing vasculature.
Tissue engineering - expand cells in culture, seed cells onto scaffold, culture engineered tissue in bioreactor, patient (take tissue biopsy), cells suspension (isolated from biopsy), cycle restarts.
Cardiac patch - ?
What is the critical challenge solutions will face when resolving the needs of the post heart attack patient?
What is a major need in tissue engineering? What is the current level of achievement. Why does this need exist?
Current tissue engineering success limited to thin, avascular tissues (<2mm).
Network of vessels necessary to provide nutrients and oxygen to cells in thicker tissues.