Chapter 1-statistics.txt

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Anonymous
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29661
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Chapter 1-statistics.txt
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2010-08-11 21:49:46
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Stockham Scott Vet Clin Path
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Chapter 1
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  1. What is the minimum # of subjects required to establish a reference interval? (according to this text)
    60
  2. Reference limits for data showing a normal distribution are calculated values representing what?
    Mean+/- 2 SD
  3. What is the likelihood of one value falling outside the Ref. Int?
    (1-0.95n)x100
  4. T/F: Reference intervals represent results expected in all healthy animals.
    F represents expected results in 95% of healthy animals
  5. "Why is ""reference range"" and inappropriate term?"
    b/c statistically it means the difference b/w the high and low values
  6. T/F: Analytical precision is the ability of an assay to get the same result if the same sample is analyzed several times
    T
  7. "Calculate the CV for the following diagnostic tests. Test A: Mean=10, SD=3, Test B: Mean=50, SD=4"
    "A:30%, B:8%" CV=(SD/Mean)x100
  8. Which test is more precise?
    B low CV-> high prec
  9. T/F: Within-assay CV represents random error w/in a run of the assay and the error from additional runs of the assay on the same sample.
    F That is between-assay CV
  10. "If a clinical decision is based on a minimal change in the value of an analyte, should the CV be high or low?"
    Low
  11. What term represents the ability of a test to produce a change in the signal for a defined change of the quantity?
    Analytical Sensitivity
  12. Define accuracy.
    the closeness of the agreement b/w the measured value and the true value
  13. Define analytical specificity
    ability to detect only the substance of interest freedom from interference
  14. T/F: A test w/ high diagnostic specificity is a good screening test.
    "F, screening tests should have high sensitivity"
  15. A test w/ high diagnostic sensitivity has few (FN/FP) results. Choose one
    FN
  16. Define positive predictive value.
    the probablitiy that a positive test indicates that the animal has the disease PPV=TP/(TP + FP)
  17. "When prevalence is low, which is more likely to occur? FN or FP"
    FP
  18. A test with few FN compared to TN results has a high (PPV/NPV). Choose one.
    NPV NPV=TN/(TN +FN)
  19. T/F: The clinical value of the calculated diagnostic properties is influenced by prevalence.
    T
  20. PPV is less when the disease prevalence is (high/low). Choose
    low
  21. "Disease prevalence=10%, n=1000, sensitivity=94%, specificity=85%. Calculate TP, FP, TN, FN, PPV and NPV"
    "TP=94, FP=135, TN=765, FN=6, PPV=41%, NPV=99%"
  22. What happens to the PPV when the prevalence increases to 25%?
    It increases b/c TP increase and FP decrease

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