Releases histamine and heparin in areas of tissue damage causing the manifestations of inflammation.
It contains Vasoactive Amine
s or chemicals (heparin, histamine, seratonin, kinins and leukotrienes) that are released. it acts on smooth muscle and blood vessel walls.
- heparin - inhibits clotting
- histamine - constrict small veins (inhibits blood flow and venous return) and respiratory smooth muscles (restricting airways) resulting in blood collecting in capillaries and arterioles
- seratonin -
- kinins - dilate arterioles and increase capillary permeability causing plasma to leak into interstitial space (vascular leak syndrome)
- leukotrienes -