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CTEPBA
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The etiology of IDA is?
- nutrition deficiency
- Faulty iron absorption
- excessive loss of iron
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Iron deficiency is still common in?
- toddlers
- adolescent girls
- women of childbearing age
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Decreased iron intake is associated with?
Meet-poor diet
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Physiological iron lass is associated with?
Menstruation
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Increased iron utilization is associated with?
Adolescent growth spurt
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Pathological iron lass is associated with?
Colon cancer
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Decreased iron intake is associated with?
Sprue
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The average adult has ____g of iron
3.5g - 5.0g
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Most functional iron in humans is found in?
Hemoglobin molecules of erythrocytes (RBC)
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Approximately ____% of iron from food is in the form of _____ iron?
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Most ingested iron is readily absorbed into the body in the ?
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Transferrin represents a?
- Beta globulin that moves iron
- Glycoprotein that moves iron
(Beta globulin glycoprotein)
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In IDA, the erythrocytic indices are typically ?
- MCV - decreased
- MCH - decreased
- MCHC - decreased
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Peripheral blood smear demonstrates ______ red blood cells in IDA?
Microcytic, Hypochromic
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Anemias of inflomation/chronic diseases can be caused by?
- Inflammation
- Infection
- Malignancy
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AOI can result from?
- inappropriately decreased erythropoietin
- suppression of erythropoiesis by cytokine from activated macrophages and lymphocytes
- impaired iron metabolism
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The typical peripheral blood film of a patient with AOI typically reveals _____ erythrocytes?
Normocytic, normochromic
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Leukoerythroblastosis can appear as ______ on a peripheral blood smear?
- Immature leukocytes
- Immature erythrocytes
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What is the most appropriate treatment for AOI?
treatment of inflammatory condition
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Sideroblastic anemia can be caused by?
- congenital ( chromosomal) defect
- drugs
- association with malignant disorders
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A common feature of sideroblastic anemia is?
Ringed sideroblasts
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The greatest portion of operational body iron is normally contained in what compound?
Hemoglobin
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Storage Iron in a human body is?
- found in Hepatocytes
- found in Macrophages
- sequestered as Ferritin
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The most sensitive assay for the diagnosis of hereditary hemochromatosis (HH) is
transferrin saturation
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in IDA, the ?
serum iron is severely decreased and the TIBC is increase
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