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How fast after injury does acute inflammation occur?
Within 1-2 minutes
What is the role of leukocytes in inflammation and repair?
- They help clear the injury site of invading bacteria
- Degrade necrotic by-products
What is the process of acute inflammation?
- Presence of WBCs
What are the possible outcomes of acute inflammation?
- Complete resolution
- Abcess formation
- Progression to chronic inflammation
What cells are infiltrated to the site in chronic inflammation:
- Plasma cells
What 3 processes are occurring simultaneously in chronic inflammation?
- Active inflammation
- Tissue injury
Who are the typical culprits of chronic granulomatous bacterial inflammations?
- Both mycobacteria
Who are the typical culprits of chronic granulomatous fungal inflammations?
What are the typical culprits of chronic granulomatous foreign body inflammations?
What are the most common etiologies of binocular, anterior, chronic, granulomatous uveitis?
TB and Sarcoidosis
What are 7 events that affect wound healing?
- Local infection
- Decreased blood supply
- Decreased peripheral blood flow
- Immunocompromised states
- Other systemic infection
- Increased glucocorticoid production
What reversible causes cellular injury?
Decreased blood/O2 supply (hypoxia)
What does reversible cell injury do?
- Causes increase in glycolysis and anaerobic respiration
- Causes decrease in ATP production
What happens when there is an increase in glycolysis and anaerobic respiration?
- Increase in lactic acid concentration
- Decrease in pH
What happens when there is a decrease in ATP production?
Disrupts the Na/K gradient, leading to edema, and eventual necrosis
What types of necrosis are there?
When would you expect to see coagulative necrosis?
When would you expect to see liquefactive necrosis?
Fungal infections in the lung
When would you expect to see caseous necrosis?