neoplasia and integumentary NBEO.txt
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What is the 2nd most common form of skin cancer?
Squamous cell carcinoma
What are oncogenes?
Cancer activator genes
What forms of benign cancer are there?
- Adenomas (glandular)
- Cystadenomas (cystic masses)
What is a sarcoma?
Malignant mesenchymal (connective) tissues
What is a carcinoma?
Malignant epithelial cells
What is the most common primary orbital malignancy?
What is the most common cancer of young women?
What are the ABCDE's of melanoma?
- Border irregularity
- Color differences
- Large diameter
- Enlarging size
How is basal cell carcinoma described?
Shiny, firm, pearly nodule
What is rodent ulcer?
Basal cell carcinoma
What part of the skin is affected in BCC?
Basal cell of epidermis
What part of the skin is affected with SCC?
Stratum spinosum of epidermis
What is glioblastoma multiforme?
- Most common primary malignant brain tumor
- Less than a year life expectancy
What is the most common intraocular cancer of the eye?
Where does primary melanoma metastasize to first?
What is sebaceous gland carcinoma?
Cancer of meibomian glands that can resemble chalazion
What is a macule?
- Flat area with change of color <1cm
What is a papule?
- Elevated, less than 1 cm
What is a patch?
- Flat, irregular macule bigger than 1 cm
- Caf? au lait spots
What is a plaque?
- Elevated, rough, firm lesion greater than 1 cm
What is a nodule?
Elevated, firm lesion 1-2 cm
What is eczema?
Thick areas on hands and wrist and face that are pruritic
What is psoriasis?
Scaling lesions on knees, elbows, scalp
What is seborrheic dermatitis?
What is the tx for psoriasis?
Methotrexate, UVB exposure
What is impetigo?
Gram + infection with yellow crusts
What does nail clubbing signify?
Respiratory / cardiovascular disorders
What is CREST syndrome?
- Esophageal dysmotility
What is the outer layer of the skin called?
What is the epidermis made of?
Stratified squamous keratinized epithelium
What are the layers of the epidermis from most internal to most external?
- Stratum basal
- Stratum spinosum
- Stratum granulosum
- Stratum lucidum
- Stratum corneum
How long does it take for keratin cells to become the stratum corneum from the stratum basal?
Where in the epidermis is keratin produced?
What does the dermis do?
- Contains sensory nerve endings
- Contains vascularization
What type of nerve endings account for the sense of touch in the dermis?
- Open-ended endings
- Encapsulated nerve endings
What are Ruffini/Merkel discs?
Open-ended nerve endings for touch
What are pacinian corpuscles?
Encapsulated nerve endings for touch and pressure
What type of nerve endings sense pain?
What is the hypodermis?
- Adipose tissue under the dermis
- Hair follicles
- Serves as an insulator
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