Therapeutics - Schizophrenia 2

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kyleannkelsey
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297143
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Therapeutics - Schizophrenia 2
Updated:
2015-02-28 22:20:41
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Therapeutics Schizophrenia
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Therapeutics - Schizophrenia
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Therapeutics - Schizophrenia
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  1. Which Atypical antipsychotic causes the least Weight Gain:
    • Geodon (ziprasidone)
    • And
    • Abilify (aripiprazole)
  2. Which Atypical antipsychotic causes the least Hyperprolactinemia:
    • Clorazil (clozapine)
    • And
    • Seroquel (Quetiapine)
  3. Which Atypical antipsychotic causes the least Hyperglycemia:
    • Geodon (ziprasidone)
    • And
    • Abilify (aripiprazole)
  4. Which Atypical antipsychotic causes the least Hyperlipidemia:
    • Geodon (ziprasidone)
    • And
    • Abilify (aripiprazole)
    • (Risperdal is just a little higher at +)
  5. Which Atypical antipsychotic causes the least QTc Prolongation:
    • Abilify (aripiprazole)
    • (Zyprexa is just a little higher at +)
  6. Which Atypical antipsychotic causes the most Sedation:
    Clorazil (clozapine)
  7. Which Atypical antipsychotic causes the most Anticholinergic:
    Clorazil (clozapine)
  8. Which Atypical antipsychotic causes the most Orthostatic:
    Clorazil (clozapine)
  9. Which Atypical antipsychotic causes the most EPSE:
    Risperdal (Risperdone)
  10. Which Atypical antipsychotic causes the most Weight Gain:
    • Clorazil (clozapine)
    • (Then Zyprexa at +++)
  11. Which Atypical antipsychotic causes the most Hyperprolactinemia:
    Risperdal (Risperdone)
  12. Which Atypical antipsychotic causes the most Hyperglycemia:
    • Clorazil (clozapine)
    • (Followed by Zyprexa at +++)
  13. Which Atypical antipsychotic causes the most Hyperlipidemia:
    • Clorazil (clozapine)
    • (Followed by Zyprexa at +++)
  14. Which Atypical antipsychotic causes the most QTc Prolongation:
    Geodon (ziprasidone)
  15. What is the generic name for Clozaril
    clozapine
  16. What is the generic name for Risperdal
    risperidone
  17. What is the generic name for Zyprexa
    olanzapine
  18. What is the generic name for Seroquel
    quetiapine
  19. What is the generic name for Geodon
    ziprasidone
  20. What is the generic name for Abilify
    aripiprazole
  21. What is the brand name for clozapine
    Clozaril
  22. What is the brand name for risperidone
    Risperdal
  23. What is the brand name for olanzapine
    Zyprexa
  24. What is the brand name for quetiapine
    Seroquel
  25. What is the brand name for ziprasidone
    Geodon
  26. What is the brand name for aripiprazole
    Abilify
  27. What is the generic name for Thorazine
    chlorpromazine
  28. What is the generic name for Prolixin
    fluphenazine
  29. What is the generic name for Stelazine
    trifluoperazine
  30. What is the generic name for Trilafon
    perphenazine
  31. What is the generic name for Navane
    thiothixene
  32. What is the generic name for Haldol
    haloperidol
  33. What is the generic name for Loxitane
    loxapine
  34. What is the generic name for Orap
    pimozide
  35. What is the brand name for chlorpromazine
    Thorazine
  36. What is the brand name for fluphenazine
    Prolixin
  37. What is the brand name for trifluoperazine
    Stelazine
  38. What is the brand name for perphenazine
    Trilafon
  39. What is the brand name for thiothixene
    Navane
  40. What is the brand name for haloperidol
    Haldol
  41. What is the brand name for loxapine
    Loxitane
  42. What is the brand name for pimozide
    Orap
  43. What is Acute Dystonia and when does it arise?
    • Spasmodic or sustained muscle spasms
    • Few hours – 1 month
  44. What is Akathisia and when does it arise?
    • Sever motor restlessness
    • Days – weeks
  45. What is Pseudoparkinsonism and when does it arise?
    • Bradykinesia, mask-like face, resting tremor
    • 1 – 3 months
  46. What is Tardive Dyskinesia and when does it arise?
    • Mouth movements including lip smacking, puckering, tongue protusion
    • 1 year or longer
  47. What antipsychotics cause the lowest seizure threshold?
    • Low potency (except thioridazine)
    • Loxitane (loxapine)
    • Clorazil (Clozapine)
    • Seroquel (Quetiapine)
  48. Which Antipsychotics are CYP3A4 metabolized?
    • Abilify (aripiprazole)
    • Lurasidone (Latuda)
    • Clapine (Clorazil)
    • Iloperidone (Fanapt)
    • Quetiapine (Seroquel)
    • Ziprasidone (Geodon)
  49. What is Abilify (aripiprazole) used to treat
    • Schizophrenia
    • Bipolar
    • Major Depressive
    • Autism
  50. What is Lurasidone (Latuda) used to treat
    Schizophrenia
  51. What is Asenapine (Saphris) used to treat
    • Schizophrenia
    • Bipolar
  52. What is Clapine (Clorazil) used to treat
    Schizophrenia
  53. What is Iloperidone (Fanapt) used to treat
    Schizophrenia
  54. What is Olanzapine (Zyprexa) used to treat
    • Schizophrenia
    • Bipolar
    • Major Depressive
  55. What is Paliperidone (Invega) used to treat
    Schizophrenia
  56. What is Quetiapine (Seroquel) used to treat
    • Schizophrenia
    • Bipolar
    • Major Depressive
  57. What is Risperidone (Risperdal) used to treat
    • Schizophrenia
    • Bipolar
    • Autism
  58. What is Ziprasidone (Geodon) used to treat
    • Schizophrenia
    • Bipolar
  59. How is pseudoparkinsonism treated?
    Reduce dose of antipsychotic(s), add anticholinergics, symptoms disappear within 3 months of treatment, then reduce dose or discontinue the anticholinergic agent
  60. How is Dystonia treated?
    • Diphenhydramine (Benadryl®) 50mg intravenous or benztropine (Cogentin®) 2mg intravenous (effective in 2 minutes)
    • If no relief in 5 minutes then repeat dose
    • The intramuscular route will be effective in 20 to 40 minutes
    • Anticholinergics for duration of event then 3-5 days after last dosage increase.
  61. How is Akethesia treated?
    Lower the antipsychotic dose; switch antipsychotics
  62. How is NMS treated?
    • Primary – supportive – cooling blankets (antipyretics don’t work well)
    • Discontinue antipsychotic (after discontinue symptoms can last 5-10 days)
    • Secondary – for rigidity – anticholinergics possible – may not work well
    • Dantrolene – a direct skeletal muscle relaxant – 100-300mg/day given in divided doses po or 1.25-1.5mg/kg IV as a single dose
  63. How is Tardive Dyskinesia treated?
    • Treatment – prevention – proper indication for antipsychotic use; the minimum dose and duration of treatment as possible.
    • Vitamin E – decreases free radicals can be use preventatively and therapeutically – more studies needed.
    • Clozapine – may consider a switch to.
    • - Drug holidays make it worse, so don’t do
  64. Which Antipsychotic causes the most Hematological effects?
    Clorazil
  65. How do you treat Amenorrhea or Galactorrhea?
    • Change to Olanzapine or Clozapine
    • Give Amantadine or Bromocriptine
  66. Which Antipsychotic is most likely to cause Photosensitivity?
    Chlorpromazine
  67. How is Psychogenic Polydipsia treated?
    Demeclocycine 600 mg PO BID
  68. What is the “best” antipsychotic for pregnancy
    Latuda (B rating)
  69. What is the proposed MOA for Atypical Antipsychotics?
    Blockade of serotonin 2A receptors and dopamine 1 and dopamine 2 receptors
  70. What are the major points for Clorazil?
    • 5 BB Warnings: agranulocytosis, seizures, myocarditis, other cardiovascular and respiratory side effects, and dementia
    • Must restart drug at lower dose if been a few days since last took or risk myocarditis
    • Titrate slowly to avoid sedation, respiratory distress and Hypotension
    • Must have WBC >3000 or ANCs> 1500
    • Highest seizure potential
  71. What are the major points of Risperdal?
    • Most like Typicals (Haloperidol)
    • SE: Anxiety, sedation, EPSE, constipation, Nausea, dyspepsia, Hyperprolactinemia (most likely to cause), OH, rhinitis and rash
    • Requires slower titration
    • Potential for priapism
  72. What are the major points of Ivega (palperidone)?
    Active metabolite of risperdone used when liver cannot metabolize risperdone
  73. What are the major points of Zyprexa?
    • SE: Dizziness, constipation, OH, Hypotention, WG/Trig/BG, akathesia, excessive sedation (dose QHS)
    • Metabolic syndrome is high – worst for thin or normal BMIs
  74. What are the major points of Seroquel?
    • SE: Dizziness, sedation, postural hypotension, dry mouth and dyspepsia
    • Really sedative = don’t drive
    • Sedation at low doses
  75. What are the major points of Geodon (ziprasidone)?
    • Take with food to maintain absorption
    • QT prolongation – avoid w/ significant CV disease (potentially get ECG before commencement)
    • May decrease Triglycerides
    • Weight neutral
  76. What are the major points fo Abilify?
    • SE: HA, asthenia, nausea/vomiting, constipation, anxiety, insomnia, lightheadedness, sedation, akathesia and rash
    • Excitatory
    • Less metabolic syndrome
  77. What Antipsychotic comes as a SL tablet?
    Saphris (asenapine)
  78. What are the major points for Latuda (lurasidone)?
    • Middle of road for WG
    • 5-HT subtype 7 activity may help with cognition
    • Must take with 300-600 calories to get good F
    • Pregnancy Category B

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