renin

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Author:
klerandi
ID:
297151
Filename:
renin
Updated:
2015-03-01 01:39:20
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renin
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renin
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scifna/
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  1. is a hormonal system that plays a central role in the control of Na excretion and body fluid volume
    renin angiotensin system
  2. is an enzyme secreted into the blood from specialized cells that encircle the arterioles at the entrance to the glomeruli of the kidneys
    renin
  3. primary stimulus for increased renin secretion
    decreased blood flow to the kidneys
  4. decreased blood flow to the kidneys is caused by (2)
    • loss of sodium and water
    • narrowing of a renal artery
  5. promotes secretion of aldosterone
    andiotensin II
  6. other name of aldosterone
    anti diuretic hormone
  7. stimulates salt and water reabsorption by the kidneys and the constriction of small arteries which may cause increase in BP
    aldosterone
  8. less potent but significant regulatory effect on sodium excretion by the renal tubules
    angiotensin 3
  9. 4 major types of drugs that act on the renal system
    • ACE inhibitor
    • Angiotensin II blockers
    • renin inhibitor
    • aldosterone antagonist
  10. agents of choice for heart failure
    ACE inhibitor
  11. drugs that block the enzyme that cleaves angiotensin 1 to form the potent vasoconstrictor angiotensin 2
    ACE inhibitor
  12. receptor antagonists at the mineral corticoid receptor
    aldosterone antagonist
  13. results of aldosterone antagonist (2)
    • interferes with sodium/potassium exchange
    • reducing urinary potassium secretion
  14. fomula for BP
    BP = CO X TPR
  15. agents that block aldosterone that may be used in the management of hypertension of HF
    • spironolactone (BN)
    • eplerenone (BN)

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