angio 2

Card Set Information

Author:
klerandi
ID:
297155
Filename:
angio 2
Updated:
2015-03-01 03:56:35
Tags:
angio
Folders:
renin
Description:
kjbklbk
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  1. First nonpeptide imidazole to be introduced as an orally active angiotensin II antagonist with high specificity for AT1.
    losartan
  2. Imidazole system has been replaced with a benzimidazole

    possessing an ester
    at position 7.
    candesartan
  3. Does not possess the acidic side chain. But has good affinity for the angiotensin II receptor because of hydrogen bonding with the carbonyl
    moiety of the amide system.
    Irbesartan
  4. No resemblance to the group when it comes to structure but difference is the replacement of the acidic tetrazole system with a simple carboxylic acid which plays a role in receptor binding.
    Telmisartan
  5. Rapidly and completely bioactivated by ester hydrolysis of the medoxomil during absorption from the gastrointestinal tract when administered to patients.
    olmesartan
  6. Possesses the acidic tetrazole system.
    valsartan
  7. First renin inhibitor introduced into the U.
    S. market. It was approved by the FDA in 2007 for the management of HTN.
    Aliskeran

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