cholinergic

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Author:
klerandi
ID:
297195
Filename:
cholinergic
Updated:
2015-03-03 12:14:00
Tags:
choli
Folders:
phchem
Description:
dskgvn
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  1. Described the actions of the esters and ethers of choline on isolated organs and their relationship to muscarinic, pharmacologist, physiologists, chemists, and
    biochemists have applied their knowledge to understand the actions of the cholinergic nerve and its neurotransmitter
    Dale
  2. Found in the Central and Peripheral nervous system and use Ach as their neurotransmitter
    Cholinergic Receptor
  3. Cholinergic receptors use ____ as neurotransmitter
    Ach
  4. 2 kinds of cholinergic receptor
    • Nicotinic
    • Muscarinic
  5. Ionotropic receptors or Ligand-gated ion channels

    Responsive to Ach and Nicotine
    Nicotinic
  6. Metabolic receptors or G-protein couple receptors

    Responsive to Ach and Muscarine
    Muscarinic
  7. 2 subtype of Ncotinic Cholinergic Receptors
    Ganglionic receptor (neural) N2

    Muscle receptor (somatic) N1
  8. Ganglionic receptor (neural) N2 is blocked by ______ and ________ but stimulated by __________ and ___________
    hexamethonium

    trimethaphan

    tetramethylammonium

    dimethyl 4-phenylpiperazinium
  9. Muscle receptor (somatic) N1 is blocked by ______, _______ and ________ and stimulated by ________
    • succinycholine
    • d-tubocurarine
    • decamethonium

    phenyltrimethylammonium
  10. Muscle receptor (somatic) N1 is blocked by ______, _______ and ________ and stimulated by ________
    • succinycholine
    • d-tubocurarine
    • decamethonium

    phenyltrimethylammonium
  11. Post synaptic on neuromuscular junctions
    Muscle receptor (somatic) N1
  12. Found  in both the CNS and PNS
    Ganglionic receptor (neural) N2
  13. responsible for transmission at sympathetic and
    parasympathetic ganglia
    Ganglionic receptor (neural) N2
  14. responsible for skeletal muscle contraction
    Muscle receptor (somatic) N1
  15. Second-messenge systems that cause muscle contraction
    Phosphoinositol system
  16. Second-messenge systems that cause smooth muscle relaxation
    Adenylate cyclase
  17. Second-messenge systems that slows heart rate
    Ion channels
  18. provide the primary source of acetylcholine to
    the cerebral cortex, and are known for their role in promoting cortical activation during both wakefulness and during rapid eye movement (REM) sleep
    Cholinergic Neurons
  19. the specific study of neurochemicals  including neurotransmitters and other molecules (such as psychopharmaceuticals) that influence the function of neurons
    Neurochemistry
  20. is the study of the chemistry involved
    in the relative spatial arrangement of atoms and molecules
    Stereochemistry
  21. study of spatial arrange of cholinergic atoms and molecules
    Cholinergic Stereochemistry
  22. is a method of determining the arrangement of atoms within a crystal, in which a beam of X-rays strikes a crystal and diffracts into many specific directions
    X-ray crystallography
  23. a physical phenomenon in which nuclei in a magnetic field absorb and re-emit electromagnetic radiation
    Nuclear magnetic resonance
  24. encompasses all theoretical methods and computational techniques used to model or
    mimic the behaviour of molecules.
    Molecular modeling by computation
  25. The study of the relationship between
    a drug's molecular structure and the drug's biological activity
    Structure Activity Relationship
  26. Receptors that block synapses of the parasympathetic nerves
    Cholinergic Receptor Antagonists
  27. other name of cholinergic antagonist
    • cholinergic blockers, parasympatholytics or
    • anticholinergic
  28. inhibit the cholinesterase enzyme from breaking
    down ACh, increasing both the level and duration of the neurotransmitter action
    AChE inhibitors or anti-cholinesterases
  29. is an enzyme that specifically cleaves Ach to acetate and choline and, thus, terminates its actions
    Acetylcholinesterase
  30. 2 types of cholinesterases in humans
    • Butyrylcholinesterase
    • (BuChE)

    • Acetylcholinesterase
    • (AChE)
  31. 2 groups of AChEi
    Reversible Inhibitors

    Irreversible Inhibitors
  32. Agents that block the transmission of ACh at the
    motor end plate
    NEUROMUSCULAR BLOCKING AGENTS
  33. depolarize the membrane of the muscle end plate.
    Depolarizing Blocking Agents
  34. was a term used to describe collectively the
    very potent arrow poisons used since early times by the South American Indians
    curare

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