Immuno- Autoimmunity Part 2.txt
Card Set Information
Immuno- Autoimmunity Part 2.txt
Autoimmune disorders that affect the epidermis.
Autoimmune disorder that affects the basement membrane.
Autoimmunity against the hair follicles result in __________.
Pemphigus complex results in immune targets _______________.
above the basal cells
Epidermal autoimmune disease found in the deep epidermis.
Pemphigus vulgaris often occurs at the ____________, causing production of antibodies against _____________.
mucocutaneous junctions; adhesion molecules
Pemphigus vulgaris results in proliferation of _________ that cannot bind to each other, leading to... (3)
keratinocytes; acantholysis, acantholytic cells, and bulla formation.
Loss of cohesion b/w cells.
Variant of pemphigus vulgaris that is associated with lymphoma and other neoplasias.
Superficial vesicular epidermal disease where Ab are against superficial adhesion molecules; cells are attacked in later stages of maturation and cornification.
Variant of pemphigus foliaceus that affects the face and ears.
Papillomatous variant of pemphigus foliaceus.
_____________ occurs at mucocutaneous junctions due to autoAb against type XVII collagen.
With bullous pemphigoid, bulla formation occurs at the _______ and ________; therefore, it is less likely to _______.
sub-epidermis; dermis; rupture
Autoimmune disease against melanocytes that first causes uveitis, leading to depigmentation of hair and skin.
uveodermatological syndrome (Vogt-Koyanagi-Harada-like syndrome)
Depigmentation of hair.
Depigmentation of skin.
5 diseases associated with SLE.
rheumatoid arthritis, polyarthritis, Sjogren's syndrome, polyarteritis nodosa, dermatomyositis
SLE often has genetic predisposition, associated with __________ and __________ deficiencies; it may be triggered by _________.
complement; Fc receptor; viral infections
SLE is more common in ________[sex] and usually responds to _____________ and ______________ therapies.
females; corticosteroid; immunosuppressive
With SLE, autoantibodies form against Ag in the _________; in dogs, the Ab are against _______ and ________, specifically.
nucleus; histones; ribonucleoproteins
With SLE, ANAs bind to nuclei of _____________ to form __________.
degenerating cells; hematoxylin bodies
Phagocytosis of opsonized nuclei associated with SLE.
2 clinical outcomes of SLE.
loss of tolerance, autoantibodies formed against other cells and immune complex lesions
Diagnosis of SLE requires...
at least 2 clinical findings and either a positive ANA or LE test
What are the 5 clinical findings that can be used to make a diagnosis of lupus?
characteristic skin lesions, polyarthritis, antiglobulin positive anemia, thrombocytopenia, proteinuria
Horses with SLE often present with... (2)
generalized skin disease, antiglobulin positive anemia
Dogs with SLE often present with... (2)
polyarthritis, progressive disease
Cats (uncommon) with lupus often present with... (1)
antiglobulin positive anemia
Discoid lupus erythematosus is characterized by ______________ only; it is exacerbated by __________ and treated by ____________.
skin lesions; exposure to sun; corticosteroids
Autoimmune polyarthritis that is erosive.
Autoimmune polyarthritis that is non-erosive.
Rheumatoid arthritis is likely stimulated by ___________; it also has a _________ component.
infectious agents; genetic
With rheumatoid arthritis, there are autoantibodies against _______, _________, and __________.
IgG; type II collagen; glycosaminoglycan autoantigens
With rheumatoid arthritis, activation of cytokines, complement, neutrophils, and osteoclasts leads to... (4)
synovitis, pannus formation (abnormal layer of granulation or fibrovascular tissue), protease secretion, and cartilage and bone erosion.
Rheumatoid factors are ______________.
In dogs with rheumatoid arthritis, _______ and ________ RFs are seen.
Detection of RF is via the _____________.
latex agglutination test
Polyarthritis/ polysynovitis can extend to the _________, __________ and __________; the synovial effusions are ______ and are characterized by ______________.
tendon sheaths; bursae; joint; sterile; suppurative (neutrophilic) inflammation
Horses with primary polyarthritis also often have signs of ______________; it is often reported in association with ________________ in foals as a secondary disease.
systemic inflammation; Rhodoccus equi pneumonia
Polyarthritis in dogs:
Type I- uncomplicated without other disease
Type II- in association with infectious diseases outside of the joints
Type III- in association with GI disease
Type IV- in association with neoplastic disease
Polyarthritis in cats is in association with ___________ and/ or _________.
feline syncytia-forming virus; FeLV
A diagnostic triad consisting of keratoconjunctivitis sicca, xerostomia, and the presence of RF.
Keratoconjunctivitis sicca (KCS) is a common ___________ in dogs that results in __________; it is the result of an immune attack on the ___________.
ophthalmic disorder; corneal dryness; lacrimal glands
Xerostomia results in ________; it is due to an immune attack on the _________.
dry mouth; salivary glands
With immune diseases against the neuroendocrine organs, autoantibodies may be produced against ________________, ______________ which can be destroyed by ___________, and there may be ____________.
key enzymes/hormones; structural components; ADCC; CD8 mediated destruction
With lymphocytic thyroiditis, there is a _____________ seen in the __________; autoantibodies are formed against __________ or __________, resulting in ADCC.
lymphoplasmacytic infiltrate; thyroid; thyroglobulin; thyroid peroxidase
With insulin dependent diabetes mellitus, autoantibodies are formed against the ____________________; this results in destruction of ________ and __________.
islet cell enzyme glutamic acid decarboxylase (GAD); β cells; islet atrophy
Myasthenia gravis may be associated with ___________ or ___________; clinical manifestations are due to antibody against the ___________ that blocks the binding of _________.
thymic hyperplasia; thymic neoplasia; acetylcholine binding site; acetylcholine
With myasthenia gravis, __________ drugs slow the degradation of Ach and allow for enhanced competition for binding.