Immuno- Autoimmunity Part 2.txt

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Immuno- Autoimmunity Part 2.txt
2015-03-02 18:03:57

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  1. Autoimmune disorders that affect the epidermis.
    pemphigus family
  2. Autoimmune disorder that affects the basement membrane.
    bullous pemphigoid
  3. Autoimmunity against the hair follicles result in __________.
  4. Pemphigus complex results in immune targets _______________.
    above the basal cells
  5. Epidermal autoimmune disease found in the deep epidermis.
    pemphigus vulgaris
  6. Pemphigus vulgaris often occurs at the ____________, causing production of antibodies against _____________.
    mucocutaneous junctions; adhesion molecules
  7. Pemphigus vulgaris results in proliferation of _________ that cannot bind to each other, leading to... (3)
    keratinocytes; acantholysis, acantholytic cells, and bulla formation.
  8. Loss of cohesion b/w cells.
  9. Variant of pemphigus vulgaris that is associated with lymphoma and other neoplasias.
    Paraneoplastic pemphigus
  10. Superficial vesicular epidermal disease where Ab are against superficial adhesion molecules; cells are attacked in later stages of maturation and cornification.
    pemphigus foliaceus
  11. Variant of pemphigus foliaceus that affects the face and ears.
    pemphigus erythematosus
  12. Papillomatous variant of pemphigus foliaceus.
    pemphigus vegetans
  13. _____________ occurs at mucocutaneous junctions due to autoAb against type XVII collagen.
    Bullous pemphigoid
  14. With bullous pemphigoid, bulla formation occurs at the _______ and ________; therefore, it is less likely to _______.
    sub-epidermis; dermis; rupture
  15. Autoimmune disease against melanocytes that first causes uveitis, leading to depigmentation of hair and skin.
    uveodermatological syndrome (Vogt-Koyanagi-Harada-like syndrome)
  16. Depigmentation of hair.
  17. Depigmentation of skin.
  18. 5 diseases associated with SLE.
    rheumatoid arthritis, polyarthritis, Sjogren's syndrome, polyarteritis nodosa, dermatomyositis
  19. SLE often has genetic predisposition, associated with __________ and __________ deficiencies; it may be triggered by _________.
    complement; Fc receptor; viral infections
  20. SLE is more common in ________[sex] and usually responds to _____________ and ______________ therapies.
    females; corticosteroid; immunosuppressive
  21. With SLE, autoantibodies form against Ag in the _________; in dogs, the Ab are against _______ and ________, specifically.
    nucleus; histones; ribonucleoproteins
  22. With SLE, ANAs bind to nuclei of _____________ to form __________.
    degenerating cells; hematoxylin bodies
  23. Phagocytosis of opsonized nuclei associated with SLE.
    LE bodies
  24. 2 clinical outcomes of SLE.
    loss of tolerance, autoantibodies formed against other cells and immune complex lesions
  25. Diagnosis of SLE requires...
    at least 2 clinical findings and either a positive ANA or LE test
  26. What are the 5 clinical findings that can be used to make a diagnosis of lupus?
    characteristic skin lesions, polyarthritis, antiglobulin positive anemia, thrombocytopenia, proteinuria
  27. Horses with SLE often present with... (2)
    generalized skin disease, antiglobulin positive anemia
  28. Dogs with SLE often present with... (2)
    polyarthritis, progressive disease
  29. Cats (uncommon) with lupus often present with... (1)
    antiglobulin positive anemia
  30. Discoid lupus erythematosus is characterized by ______________ only; it is exacerbated by __________ and treated by ____________.
    skin lesions; exposure to sun; corticosteroids
  31. Autoimmune polyarthritis that is erosive.
    rheumatoid arthritis
  32. Autoimmune polyarthritis that is non-erosive.
    polyarthriti/ polysynovitis
  33. Rheumatoid arthritis is likely stimulated by ___________; it also has a _________ component.
    infectious agents; genetic
  34. With rheumatoid arthritis, there are autoantibodies against _______, _________, and __________.
    IgG; type II collagen; glycosaminoglycan autoantigens
  35. With rheumatoid arthritis, activation of cytokines, complement, neutrophils, and osteoclasts leads to... (4)
    synovitis, pannus formation (abnormal layer of granulation or fibrovascular tissue), protease secretion, and cartilage and bone erosion.
  36. Rheumatoid factors are ______________.
    anti-Ig antibodies
  37. In dogs with rheumatoid arthritis, _______ and ________ RFs are seen.
    IgG; IgM
  38. Detection of RF is via the _____________.
    latex agglutination test
  39. Polyarthritis/ polysynovitis can extend to the _________, __________ and __________; the synovial effusions are ______ and are characterized by ______________.
    tendon sheaths; bursae; joint; sterile; suppurative (neutrophilic) inflammation
  40. Horses with primary polyarthritis also often have signs of ______________; it is often reported in association with ________________ in foals as a secondary disease.
    systemic inflammation; Rhodoccus equi pneumonia
  41. Polyarthritis in dogs:
    Type I-
    Type II-
    Type III-
    Type IV-
    • Type I- uncomplicated without other disease
    • Type II- in association with infectious diseases outside of the joints
    • Type III- in association with GI disease
    • Type IV- in association with neoplastic disease
  42. Polyarthritis in cats is in association with ___________ and/ or _________.
    feline syncytia-forming virus; FeLV
  43. A diagnostic triad consisting of keratoconjunctivitis sicca, xerostomia, and the presence of RF.
    Sjogren's syndrome
  44. Keratoconjunctivitis sicca (KCS) is a common ___________ in dogs that results in __________; it is the result of an immune attack on the ___________.
    ophthalmic disorder; corneal dryness; lacrimal glands
  45. Xerostomia results in ________; it is due to an immune attack on the _________.
    dry mouth; salivary glands
  46. With immune diseases against the neuroendocrine organs, autoantibodies may be produced against ________________, ______________ which can be destroyed by ___________, and there may be ____________.
    key enzymes/hormones; structural components; ADCC; CD8 mediated destruction
  47. With lymphocytic thyroiditis, there is a _____________ seen in the __________; autoantibodies are formed against __________ or __________, resulting in ADCC.
    lymphoplasmacytic infiltrate; thyroid; thyroglobulin; thyroid peroxidase
  48. With insulin dependent diabetes mellitus, autoantibodies are formed against the ____________________; this results in destruction of ________ and __________.
    islet cell enzyme glutamic acid decarboxylase (GAD); β cells; islet atrophy
  49. Myasthenia gravis may be associated with ___________ or ___________; clinical manifestations are due to antibody against the ___________ that blocks the binding of _________.
    thymic hyperplasia; thymic neoplasia; acetylcholine binding site; acetylcholine
  50. With myasthenia gravis, __________ drugs slow the degradation of Ach and allow for enhanced competition for binding.