Immuno- Vaccines and Cancer.txt

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Immuno- Vaccines and Cancer.txt
2015-03-02 18:06:50

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  1. Strategy for inducing immunoprotection that results in rapid but temporary protection; eg. colostral Ab.
  2. Strategy for inducing immunoprotection that takes longer but provides longer lasting immunity; eg. vaccination.
  3. Vaccines that require fewer and smaller doses and induce longer lasting immunity.
    Live vaccines
  4. Live vaccines induce ______ and stimulate...
    IFN; humoral and cell-mediated immunity.
  5. Vaccines that are more stable and storable and are unlikely to cause disease.
    Non-live vaccines
  6. 4 types of non-live vaccines.
    inactivated virus, purified subunits, recombinant products, and DNA vaccine
  7. Modified live vaccines are _________.
  8. Inactivated vaccines have the ______________.
    whole organism killed or fixed
  9. Recombinant vaccines either...
    purify out a component (purified sub-unit) or utilize a vector to produce a sub-unit (recombinant)
  10. 3 types of antibacterial vaccines.
    toxoids, bacterins, modified live
  11. Toxoid antibacterial vaccines contain _____________.
    denatured bacterial exotoxins
  12. Bacterin antibacterial vaccines contain __________, but they are less effective.
    killed bacteria
  13. ___________ are critical to help boost the immune response with non-live vaccines.
  14. 3 ways that adjuvants help boost the immune response to a vaccine.
    slow removal of Ag, enhance Ag presentation, and stimulate TLR responses
  15. What are the core vaccines for dogs?
    parvo, distemper, adeno-2, rabies
  16. What are the core vaccines for cats?
    pankleuk, herpes, calicivirus, rabies
  17. What are the typical vaccines given to horses?
    tetanus, E/W EE, West Nile, Rabies
  18. Maternal antibodies interfere with ___________; it declines around _________.
    vaccines; 8-12 weeks of age
  19. Normal proteins found on both normal and cancer cells.
    tissue specific antigens
  20. foreign proteins expresses on virally infected cancer cells.
    viral antigens
  21. proteins that normally are not expressed after fetal development that get "turned on" by cancer.
    reactivated gene products
  22. abnormal proteins.
    mutated gene products
  23. 3 methods of active immunization as cancer immunotherapy.
    chemically modified tumor cells, DNA vaccination, vaccination against oncogenic viruses
  24. The melanoma vaccine use an _____________ to express human tyrosinase gene, which is needed for the first step of _______________.
    E. coli plasmid vector; melanin production
  25. Plasma cell neoplasia that is a solid mass.
  26. Plasma cell neoplasia that is an infiltration in BM or extramedullary sites.
  27. Benign tumors of epidermal Langerhans cells that spontaneously regress.
  28. Malignant proliferation of Langerhans cells, interstitial dendritic cells, or macrophages with marked cellular pleomorphism; erythrophagocytosis may be present.
    histiocytic sarcoma