MS- Bone Formation.txt
Card Set Information
MS- Bone Formation.txt
With both endochondral ossification and intramembranous ossification, the first tissue to be formed is ____________.
Both endochondral and intramembranous ossification can lead to the formation of ___________ or ___________.
Endochondral ossification functions in the formation of the _______________.
With endochondral ossification, the _________ is sequentially ________ and ___________.
hyaline cartilage model (anlage); resorbed; replaced with bone
Endochondral ossification results in bone growing __________ and ___________.
outward and longitudinally
Epiphyseal cartilage removal during endochondral ossification results in the __________.
secondary center of ossification
During endochondral ossification, after mineralization, _________ and __________ take place,
Endochondral ossification of the physeal cartilage take place b/w the...
primary and secondary centers of ossification
What are the 5 zones during endochondral ossification?
resting zone, proliferation zone, maturation/hypertrophy zone, calcification zone, ossification zone
What zone is closest to the joint surface/ epiphysis in endochondral ossification?
Which zone is moving into the diaphysis during endochondral ossification?
zone of ossification
The endochondral ossification zone with small, inactive mesenchymal stem cells that divide and give rise to chondrocytes/blasts.
The endochondral ossification zone that has columns of chondroblasts that are quickly dividing and pushing the epiphysis away from the diaphysis.
What endochondral ossification zone is responsible for lengthening of bone?
The growth plate is b/w the _________ and _________.
The endochondral ossification zone where chondrocytes mature and enlarge.
The endochondral ossification zone where the cartilaginous matrix calcifies to resemble trabeculae and chondrocytes die.
The endochondral ossification zone where osteoclasts degrade cartilage and osteoblasts form actual trabecular bone.
What is the key difference b/w endochondral ossification and intramembranous ossification?
intramembranous ossification does not utilize a cartilage intermediate
Intramembranous ossification involves condensation and differentiation of ______________.
mesenchymal stem cells
_____________ is circumferential bone growth.
Appositional bone growth occurs by...
direct deposition of bone at the periosteal surface.
While bone is being deposited on the periosteal surface during intramembranous ossification, bone is being _________ at the __________ surface in order to...
resorbed; endosteal; increase the size of the marrow cavity.
4 steps of bone remodeling.
1. activation 2. resorption 3. reversal 4. formation
Bone remodeling occurs at the bone surface without...
traumatic injury (normal everyday wear and tear)
The basic multicellular unit/ bone multicellular unit is composed of...
osteoblast + osteoclast
In trabecular bone remodeling, the BMU is located ____________.
on the surface
During trabecular bone remodeling, the BMU on the surface is covered by a canopy of ___________ with...
mesenchymal cell origin; osteoclasts resorbing bone.
During remodeling of cortical bone, the BMU consists of...
cutting zone led by osteoclasts.
The resultant space of the cutting zone during remodeling of cortical bone is filled by... (3)
blood vessels, nerves, and connective tissue.
Basophilic lines seen between lamellae that represent reversal points of remodeling.
______ was added on top of the cement line.
Modeling is only seen in ________________.
During bone modeling, formation ___ resorption, and there is _________ and __________ growth.
>>; longitudinal; appositional
Modeling involves changes in bone ______ and _______.
At skeletal maturity, formation ___ resorption.
4 things that drive remodeling.
mechanical loading, systemic and local hormones, trauma, microfractures
What is Wolff's law?
bone remodels according to the forces acting upon it
Bone deformation occurs due to...
piezo-electric currents, loading and unloading, and induction of osteoclast activity
Loading stimulates ____________.
Unloading stimulates ______________.
Restoration of optimal bone structure depends on _____________ and a _____________.
anatomic alignment; return to functional activity