MS- Osteoporosis.txt

Card Set Information

Author:
Mawad
ID:
297351
Filename:
MS- Osteoporosis.txt
Updated:
2015-03-02 18:11:12
Tags:
musculoskeletal osteoporosis
Folders:

Description:
vetmed
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user Mawad on FreezingBlue Flashcards. What would you like to do?


  1. Clinical disease related to reduced bone mass.
    Osteoporosis
  2. Reduced bone mass without clinical disease.
    Osteopenia
  3. 3 causes of osteoporosis.
    protein calorie malnutrition, low calcium/normal phosphorous diets, localized osteopenia/osteoporosis due to disuse
  4. Protein calorie malnutrition causes osteoporosis because there is decreased ____________, so ________ are are reduced in vigor in ____________.
    energy; osteoblasts; forming bone
  5. The pathogenesis of osteoporosis involves an imbalance b/w...
    formation and resorption during remodeling of bone.
  6. With protein calorie malnutrition, there is normal ________.
    resorption
  7. Osteoporosis that is localized due to disuse occur when there is increased ___________ and decreased ___________.
    resorption; formation
  8. With osteoporosis that is localized due to disuse, osteocytes sense ____________ and signal osteoblasts to stop forming bone via __________.
    mechanical use; sclerostin
  9. 3 structural changes that occur with osteoporosis.
    less bone, increased microcracks, pathologic fractures
  10. With osteoporosis, there are fewer trabeculae, meaning the trabeculae do not extend to the _________; there is also _________ of cortices.
    metaphyseal/diaphyseal junction; increased porosity
  11. Failure of mineralization of bone in the adult.
    osteomalacia
  12. Failure of mineralization of bone and growth place cartilage in the young animal.
    rickets
  13. 3 causes of osteomalacia/rickets.
    vitamin D deficiency, phosphorous deficiency, xenobiotics that inhibit mineralization
  14. The pathogenesis of osteomalacia/ rickets involves inadequate ______________ at the _____________.
    calcium/phosphorous product; mineralization site
  15. The pathogenesis of osteomalacia/ rickets involves lack of ____________ needed at the mineralization site or for calcium absorption in the intestines.
    vitamin D metabolites
  16. The pathogenesis of osteomalacia/ rickets involves inhibition of the ______________ by drugs.
    mineralization process
  17. With osteomalacia/rickets, there is an accumulation of __________.
    osteoid
  18. With osteomalacia/rickets, there is a retention of _________ in the growth plate due to failure of ________; this causes flaring of the metaphysis due to ________________ and failure of ______________________.
    chondrocytes; mineralization; the thickened growth plate; osteoclasts (only resorb mineralized bone) to taper the bone at the cut back zone
  19. With osteomalacia/rickets, the accumulation of microcracks is secondary to _______________.
    reduced ability to remodel bone
  20. Response of bone to pathologic levels of PTH.
    fibrous osteodystrophy
  21. 3 causes of fibrous osteodystrophy.
    primary hyperparathyroidism, secondary renal hyperparathyroidism, secondary nutritional hyperparathyroidism
  22. With secondary renal hyperparathyroidism causes a decrease in ________ with a secondary increase in _______; ________ is possible.
    serum Ca; PTH; soft tissue mineralization
  23. Secondary nutritional hyperparathyroidism causes elevated PTH due to elevated _____ in the feed, causing decreased _____________ from the intestine; ________ is not likely, unlike secondary renal hyperparathyroidism.
    P; absorption of Ca; soft tissue mineralization
  24. With fibrous osteodystrophy, PTH stimulates... (3)
    osteoclastic bone resorption, fibrous differentiation, and hyperplasia of osteoprogenitor cells.
  25. 4 structural changes associated with fibrous osteodystrophy.
    decreased bone mass, reduced bone dimensions, pliable bones, pathological fractures/deformity
  26. 3 clinical consequences of fibrous osteodystrophy.
    deformity, pathologic fractures, bone pain
  27. Stress shielding causes ________ because it simulates _________.
    osteopenia; disuse

What would you like to do?

Home > Flashcards > Print Preview