PHRD6925 MedChem Lecture 5 - Cardiac Agents

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  1. name the 2 components of cardiac glycosides
    • 1) sugar
    • 2) aglycone
  2. aglycone ring configuration
    cis, trans, cis
  3. type of linkage used to conjugate the hydroxyl group of the aglycone to a mono- or polysacharride
    Image Upload-1,4-glycosidic linkage
  4. most essential for cardiac glycoside activity
    cis, trans, cis ring configurations
  5. identify:
    Image Upload
    • PDE3 inhibitors 
    • (inamrinone, milrinone, olprinone)
  6. MOA of PDE3 inhibitors
    inhibit hydrolysis of cAMP
  7. MOA of adrenergic and dopaminergic agonists
    stimulate synthesis of cAMP
  8. MOA of nitrodilators
    mimic the actions of endogenous NO by releasing NO or forming NO within tissues
  9. identify:
    Image Upload
    nitrodilators
  10. most common SE's of organic nitrates
    headache, hypotension
  11. identify:
    Image Upload
    calcium channel blockers
  12. identify:
    Image Upload
    quinidine - prototypical Class 1A antiarrhythmic drug
  13. identify:
    Image Upload
    lidocaine - Class IB antiarrhythmic
  14. identify:
    Image Upload
    • flecainide - Class IC antiarrhythmic 
    • (fluorinated benzamide derivative)
  15. Image Upload-adrenergic receptor blocking agents, which block the role of sympathetic NS in the genesis of certain cardiac arrythmias (depress adrenergically enhanced influx through Image Upload-receptor blockade)
    • Class II antiarrhythmics
    • (eg: propranolol)
  16. identify:
    Image Upload
    propranolol - Class II antiarrhythmic
  17. antiarrhythmic that cause a homogenous prolongation of the duration of action potential which results in a prolongation of the effective refractory period (through blocking K+ channels)
    Class III inhibitors of repolarization
  18. identify:
    Image Upload
    bretylium tosylate - Class III inhibitor of repolarization
  19. administration of this class of drug causes a prolongation of the refractory period in the AV node and the atria, a decrease in AV conduction, and a decrease in spontaneous diastolic depolarization
    Class IV CCB's
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daynuhmay
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PHRD6925 MedChem Lecture 5 - Cardiac Agents
Updated:
2015-03-05 07:22:25
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medchem
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medchem
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