PHRD6925 MedChem Lecture 5 - Cardiac Agents

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daynuhmay
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297632
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PHRD6925 MedChem Lecture 5 - Cardiac Agents
Updated:
2015-03-05 02:22:25
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medchem
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medchem
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  1. name the 2 components of cardiac glycosides
    • 1) sugar
    • 2) aglycone
  2. aglycone ring configuration
    cis, trans, cis
  3. type of linkage used to conjugate the hydroxyl group of the aglycone to a mono- or polysacharride
    -1,4-glycosidic linkage
  4. most essential for cardiac glycoside activity
    cis, trans, cis ring configurations
  5. identify:
    • PDE3 inhibitors 
    • (inamrinone, milrinone, olprinone)
  6. MOA of PDE3 inhibitors
    inhibit hydrolysis of cAMP
  7. MOA of adrenergic and dopaminergic agonists
    stimulate synthesis of cAMP
  8. MOA of nitrodilators
    mimic the actions of endogenous NO by releasing NO or forming NO within tissues
  9. identify:
    nitrodilators
  10. most common SE's of organic nitrates
    headache, hypotension
  11. identify:
    calcium channel blockers
  12. identify:
    quinidine - prototypical Class 1A antiarrhythmic drug
  13. identify:
    lidocaine - Class IB antiarrhythmic
  14. identify:
    • flecainide - Class IC antiarrhythmic 
    • (fluorinated benzamide derivative)
  15. -adrenergic receptor blocking agents, which block the role of sympathetic NS in the genesis of certain cardiac arrythmias (depress adrenergically enhanced influx through -receptor blockade)
    • Class II antiarrhythmics
    • (eg: propranolol)
  16. identify:
    propranolol - Class II antiarrhythmic
  17. antiarrhythmic that cause a homogenous prolongation of the duration of action potential which results in a prolongation of the effective refractory period (through blocking K+ channels)
    Class III inhibitors of repolarization
  18. identify:
    bretylium tosylate - Class III inhibitor of repolarization
  19. administration of this class of drug causes a prolongation of the refractory period in the AV node and the atria, a decrease in AV conduction, and a decrease in spontaneous diastolic depolarization
    Class IV CCB's

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