PHRD6925 MedChem Lecture 7 - Drugs affecting the renin-angiotensin pathway and calcium blockers

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daynuhmay
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297644
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PHRD6925 MedChem Lecture 7 - Drugs affecting the renin-angiotensin pathway and calcium blockers
Updated:
2015-03-05 03:27:45
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medchem
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medchem
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  1. what is the bradykininase enzyme now known as?
    ACE
  2. identify:
    captopril - sulfhydryl-containing ACEi
  3. which portion binds to ACE?
    OH of portion [A] & O of portion [B]
  4. which portion binds to Zn?
    O & OH of portion [C]
  5. identify:
    enalaprilat - dicarboxylate-containing ACEi
  6. purpose of pyrrolidine ring:
    restrict metabolism
  7. purpose of acyloxy group:
    improve lipophilicity & bioavailability
  8. what stereochemistry much ACEi's contain to be functional?
    L-amino acid stereochemistry
  9. 3 portions of angiotensin II ARB's mimic
    • 1) C-term carboxylate
    • 2) His6 imidazole
    • 3) Ile5 n-butyl group
  10. identify:
    ARB
  11. 4 classes of CCB's
    • 1) dihydropyridines
    • 2) phenylalkylamines
    • 3) benzothiazepines
    • 4) diaminopropanol
  12. therapeutic applications of CCB's
    vasodilation - HTN, angina, arrhythmias

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