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PHRD6925 MedChem Lecture 7 - Drugs affecting the renin-angiotensin pathway and calcium blockers
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what is the bradykininase enzyme now known as?
ACE
identify:
captopril - sulfhydryl-containing ACEi
which portion binds to ACE?
OH of portion [A] & O of portion [B]
which portion binds to Zn?
O & OH of portion [C]
identify:
enalaprilat - dicarboxylate-containing ACEi
purpose of pyrrolidine ring:
restrict metabolism
purpose of acyloxy group:
improve lipophilicity & bioavailability
what stereochemistry much ACEi's contain to be functional?
L-amino acid stereochemistry
3 portions of angiotensin II ARB's mimic
1) C-term carboxylate
2) His6 imidazole
3) Ile5 n-butyl group
identify:
ARB
4 classes of CCB's
1) dihydropyridines
2) phenylalkylamines
3) benzothiazepines
4) diaminopropanol
therapeutic applications of CCB's
vasodilation - HTN, angina, arrhythmias
Author
daynuhmay
ID
297644
Card Set
PHRD6925 MedChem Lecture 7 - Drugs affecting the renin-angiotensin pathway and calcium blockers
Description
medchem
Updated
2015-03-05T08:27:45Z
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