What does it mean for a drug to have a large arteriovenous concentration gradient?
⇧Arertiovenous concentration gradient = ⇧Tissue solubility
High tissue solubility means that more anestheic is taken up from the arterial blood, which results in ⇩venous blood concentration.
- In order to achieve saturation of the blood, more anesthetic needs to be applied to replace the amount absorbed by peripheral tissue.
- Blood saturation takes longer, brain saturation is delayed and onset of action is SLOWER.