4. Describe factors that affect O2 unloading (shift to right) to tissues.
As pH drops, saturation declines, which means more O2 will be released into the tissues. Bohr effect- CO2 is primary compound responsible for Bohr effect. Carbonic anhydrase catalyzes the reaction of CO2 with H2O molecules into H2CO3 (carbonic acid), which dissociates into H+ (hydrogen ion) and HCO-3 (bicarbonate ion). The H+ generated diffuse out of RBC and plasma pH drops.Metabolic pathway, glycolysis, generate 2,3-BPH- the higher the BPH, the greater the release of O2 by Hb molecules, improves O2 delivery to tissues.