So, before an encounter with an antigen, Ig diversity is a product of combinatorial and junctional diversity. What is the theoretical numerical value, and how many times greater is this diversity than the 10^9 limit imposed by the number of B Cells in the body?
-combinatorial diversity accounts for 1,500,000 different antibodies (300 light chains x 5,000 heavy chains)
-junctional diversity accounts for a factor of 3x10^7
-these combined values, 1,500,000 x 3x10^7= 4.5x10^13 which is 10,000 times the 10^9 imposed limit