Medical Immunology (Exam II Material) Lecture 6

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mbailey585
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298220
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Medical Immunology (Exam II Material) Lecture 6
Updated:
2015-03-12 03:08:58
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Immunology
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The Development of B Lymphocytes Parham Ch. 6
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  1. What part of the immune system is B Cell function?
    adaptive immune system
  2. What are B cells responsible for?
    generating and secreting (Ig) antibiodies
  3. What do B cells transform into?
    Plasma cells
  4. What are plasma cells adept at making?
    antibodies
  5. What are "memory" B cells responsible for?
    providing rapid high-specificity/hight-affinity antibody responses if the body is presented with a pathogen for a second time.
  6. Where do B cells start their development and from what pre-cursor?
    B cells develop in the bon marrow from stem cells
  7. How many B cells are generated every day?
    >60 billion
  8. B cell inventory expands and contracts in response to...
    need and circumstance
  9. What are the six stages of B cell development?
    1. Repertoire assembly: generation of diverse clonal B cell receptors in bone marrow

    2. Negative selection: alteration, elimination, or inactivation of B cell receptors that may be self reactive

    3. Positive selection: promotion of fraction of immature B cells to become mature; occurs in secondary lymph nodes (spleen, lymph nodes, mucosa of lymphoid tissue)

    4. Searching for infection: recirculation of mature B cells between lymph, blood,a nd secondary lymphoid tissue

    5. Finding infection: activation and clonal expansion; pathogen derived antigens in secondary lymphoid tissue

    6. Attacking infection: differentiation to antibody-secreting plasma cells and memory B cells in secondary lymphoid tissue
  10. What is the sole purpose of a B cell?
    To make Ig
  11. What is the goal of  B cell in bone marrow during development?
    To become mature and express a functional B cell receptor on its cell surface
  12. What does a functional B cell receptor require to be productive during development?
    Ig gene rearrangement to produce functional IgM
  13. What are two checkpoints in the development of  B cells?

    What does failure of either checkpoints lead to?
    creation of a functional Ig heavy chain

    creation of a functional Ig light chain with cell-surface expression of B cell receptor

    failure of either, leads to apoptosis
  14. What does the Stem cell express during B cell development?
    • 1. Ig heavy chain DNA: germ-line
    • 2. Ig light chain DNA: germ-line
    • 3. Ig protein expression: none
  15. What does the Early pro B cell express during B cell development?
    • 1. Ig heavy chain DNA: D-J rearrangement 
    • 2. Ig light chain DNA: germ-line
    • 3. Ig protein expression: none
  16. What does the Late pro B cell express during B cell development?
    • 1. Ig heavy chain DNA: V-DJ rearrangement 
    • 2. Ig light chain DNA: germ-line
    • 3. Ig protein expression: none
  17. What does the Large pre B cell express during B cell development?
    • 1. Ig heavy chain DNA: VDJ rearranged (process complete) 
    • 2. Ig light chain DNA: germ-line
    • 3. Ig protein expression: μ heavy chain
  18. What does the Small pre B cell express during B cell development?
    • 1. Ig heavy chain DNA: VDJ rearranged (process complete) 
    • 2. Ig light chain DNA: V-J rearrangement
    • 3. Ig protein expression: μ heavy chain in endoplasmic reticulum
  19. What does the Immature B cell express during B cell development?
    • 1. Ig heavy chain DNA: VDJ rearranged (process complete) 
    • 2. Ig light chain DNA: VJ rearranged (process complete)
  20. When would you see the Ig expression of a functional IgM at the B cell surface?
    When you have a μ heavy chain with either a λ or κ light chain (in association with Igα or Igβ)
  21. What tissue in the bone marrow influences B cell development ?
    Bone marrow stream cells
  22. What are stroma?
    supportive cells and connective tissue of an organ
  23. How do non-lymphoid bone marrow stream cells affect B cell development?
    1. make specific contacts with developing B cells through the interaction of adhesion molecules with ligands

    2. produce growth factors acting on attached B cells
  24. Where do B cells migrate in bone as they develop?
    from the subendosteum to the central axis of bone marrow cavity as they develop, maintaining contact with stromal cells, until they eventually leave the bone marrow
  25. What rearrangement happens first in Pro B cell gene rearrangement of the μ heavy chain?
    D-J rearrangement happens first, simultaneously on both chromosomes

    D segments give functional protein sequence when read in ANY of the three possible reading frames; high probability of productive D-J rearrangement
  26. What rearrangement happens second in Pro B cell gene rearrangement of the μ heavy chain?
    VDJ rearrangement happens second

    if nonproductive in first chromosome, will happen on second

    if nonproductive on either then cell will undergo apoptosis

    This is first checkpoint (happens to 50% of cells)

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