HIV PHARMACOLOGY

Card Set Information

Author:
rere_girl4ever
ID:
298342
Filename:
HIV PHARMACOLOGY
Updated:
2015-03-13 17:04:16
Tags:
HIV PHARMACOLOGY
Folders:
HIV PHARMACOLOGY
Description:
HIV PHARMACOLOGY
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user rere_girl4ever on FreezingBlue Flashcards. What would you like to do?


  1. What is the MOA of Enfuvitide?
    Binds gp41, inhibiting viral entry.
  2. This drug used in HIV therapy binds gp41. What are its effects?
    Enfuvitide- prevents fusion and entry of the virus by inhibiting gp41
  3. Use of this drug in HIV therapy causes a skin reaction at injection sites.
    Enfuvitide- prevents fusion and entry of the virus by inhibiting gp41
  4. What adverse effects are associated with the use of Enfuvirtide?
    Skin reaction at injection sites
  5. What is the MOA of Maraviroc?
    • Binds CCR-5 on surface of T cells/monocytes, inhibiting interaction with gp120
  6. This drug inhibits interaction with gp120.
    • Maraviroc
    • Binds CCR-5 on surface of T cells/monocytes, inhibiting interaction with gp120
    • gp120 binds to CD4+ receptors
  7. This drug binds CCR-5 on surface of T cells and monocytes/ macrophages. What are its effects?
    • Maraviroc
    • Inhibits interaction with gp120 to CD4+ receptor
  8. This anti-HIV drug inhibits integrase.
    Raltegravir
  9. What is the MOA of Raltegravir?
    Inhibits HIV genome integration into host cell chromosome by reversibly inhibiting HIV integrase.
  10. This drug inhibits HIV genome integration into host cell chromosome.
    Raltegravir- inihibits integrase
  11. What side effects are associated with the use of Raltegravir?
    ⇧creatine kinase
  12. Elevated levels of creatine kinase are found in the use of this anti-HIV drug.
    Raltegravir- inihibits integrase
  13. What is the MOA of Delavirdine?
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
    • Bind to reverse transcriptase (at site different from NRTIs) and terminate the DNA chain (lack a 3′OH group)
    • Do not require phosphorylation to be active or compete with nucleotides.
  14. What is the MOA of Efavirenz?
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
    • Bind to reverse transcriptase (at site different from NRTIs) and terminate the DNA chain (lack a 3′OH group)
    • Do not require phosphorylation to be active or compete with nucleotides.
  15. What is the MOA of Nevirapine?
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
    • Bind to reverse transcriptase (at site different from NRTIs) and terminate the DNA chain (lack a 3′OH group)
    • Do not require phosphorylation to be active or compete with nucleotides.
  16. These drugs do not require phosphorylation to be active or compete with nucleotides.
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
    • Bind to reverse transcriptase (at site different from NRTIs) and terminate the DNA chain (lack a 3′OH group)
    • Do not require phosphorylation to be active or compete with nucleotides.
  17. What are the Non-nucleoside reverse transcriptase inhibitors (NNRTIs)?
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
    • Bind to reverse transcriptase (at site different from NRTIs) and terminate the DNA chain (lack a 3′OH group)
    • Do not require phosphorylation to be active or compete with nucleotides.
  18. What side effects are associated with the use of Efavirenz?
    • Vivid dreams and CNS symptoms
    • Rash
    • Hepatotoxicity
    • DO NOT USE IN PREGNANCY
  19. Vivid dreams and CNS symptoms are associated with the use of this anti-HIV medication.
    • Efavirenz
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
  20. Hepatotoxicity are associated with the use of this anti-HIV medication.
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
  21. Rash is a side effect in the use of this anti-HIV medication.
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Nevirapine
    • Delavirdine
  22. Which anti-HIV drugs are contraindicated in pregnancy?
    • Non-nucleoside reverse transcriptase inhibitor (NNRTI)
    • Efavirenz
    • Delavirdine
  23. What side effects are associated with the use of Nevirapine?
    • Rash
    • Hepatotoxicity
  24. What side effects are associated with the use of Delavirdine?
    • Rash
    • Hepatotoxicity
    • DO NOT USE IN PREGNANCY
  25. What is the MOA of Abacavir?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  26. What is the MOA of Didanosine?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  27. What is the MOA of Emtricitabine?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  28. What is the MOA of Lamivudine?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  29. What is the MOA of Stavudine?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  30. What is the MOA of Tenofovir?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Do not need to be phosphorylated to be active.
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  31. What is the MOA of Zidovudine
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain (lack a 3′OH group)
  32. This anti-HIV drug is used for general prophylaxis during pregnancy to ↓risk of fetal transmission.
    ZidovudineNucleoside Reverse Transcriptase Inhibitor (NRTI)
  33. Which anti-HIV drugs can cause bone marrow suppression? How do we treat?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Abacavir (ABC)
    • Didanosine (ddI)
    • Emtricitabine (FTC)
    • Lamivudine (3TC)
    • Stavudine (d4T)
    • Tenofovir (TDF)
    • Zidovudine (ZDV, formerly AZT)
    • Can be reverse with granulocyte colony-stimulating factor (G-CSF) and erythropoeitin
  34. What are the Nucleoside Reverse Transcriptase Inhibitors (NRTIs)?
    • Abacavir (ABC)
    • Didanosine (ddI)
    • Emtricitabine (FTC)
    • Lamivudine (3TC)
    • Stavudine (d4T)
    • Tenofovir (TDF)
    • Zidovudine (ZDV, formerly AZT)
  35. Which anti-HIV drugs can cause peripheral neuropathy?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Abacavir (ABC)
    • Didanosine (ddI)
    • Emtricitabine (FTC)
    • Lamivudine (3TC)
    • Stavudine (d4T)
    • Tenofovir (TDF)
    • Zidovudine (ZDV, formerly AZT)
  36. Which anti-HIV drugs can cause lactic acidosis?
    • NUCLEOSIDES
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Abacavir (ABC)
    • Didanosine (ddI)
    • Emtricitabine (FTC)
    • Lamivudine (3TC)
    • Stavudine (d4T)
    • Zidovudine (ZDV, formerly AZT)
  37. A side effect of this anti-HIV drug is anemia.
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Zidovudine (ZDV, formerly AZT)
  38. Which anti-HIV drug causes pancreatitis?
    • Nucleoside Reverse Transcriptase Inhibitor (NRTI)
    • Didanosine (ddI)
  39. What toxicities are associated with the use of Didanosine?
    • Pancreatitis*** 
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis
  40. What toxicities are associated with the use of Zidovudine?
    • Anemia***
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis
  41. What toxicities are associated with the use of Abacavir?
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis
  42. What toxicities are associated with the use of Emtricitabine?
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis
  43. What toxicities are associated with the use of Lamivudine?
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis
  44. What toxicities are associated with the use of Stavudine?
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis
  45. What toxicities are associated with the use of Tenofovir?
    • Bone marrow suppression
    • Peripheral neuropathy
    • DOES NOT CAUSE LACTIC ACISOSIS BECAUSE IT IS A NUCLEOTIDE
  46. What toxicities are associated with the use of Nucleoside Reverse Transcriptase Inhibitors (NRTI)?
    • Bone marrow suppression
    • Peripheral neuropathy
    • Lactic acidosis (nucleosides)
    • Anemia (Zidovudine)
    • Pancreatitis (didanosine).
  47. This protease inhibitor can boost other drug concentrations by inhibitinf cytochrome P-450
    Ritonavir
  48. This anti-HIV drug causes hyperglycemia.
    Protease inhibitors- NAVIR
  49. This anti-HIV drug causes nausea and diarrhea.
    Protease inhibitors- NAVIR
  50. This anti-HIV drug causes loss of adipose tissue on extremities, big belly, buffalo hump.
    Protease inhibitors- NAVIR
  51. This anti-HIV drug can cause hematuria.
    • Indinavir
    • Protease inhibitor
  52. What are the side effects assiociated with the use of Idinavir.
    Hematuria
  53. This anti-HIV drug can cause nephropathy.
    Protease inhibitors- NAVIR
  54. This anti-HIV drug prevents maturation of new viruses.
    Protease inhibitors- NAVIR

What would you like to do?

Home > Flashcards > Print Preview