ANTIFUNGAL THERAPY

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rere_girl4ever
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298347
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ANTIFUNGAL THERAPY
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2015-03-13 17:50:54
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ANTIFUNGAL THERAPY
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ANTIFUNGAL THERAPY
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  1. This drug binds ergosterol and forms membrane pores that allow leakage of electrolytes.
    • Amphotericin B 
    • Nystatin
  2. What is the MOA of Amphotericin B?
    Binds ergosterol and forms membrane pores that allow leakage of electrolytes.
  3. What is the MOA of Nystatin?
    Binds ergosterol and forms membrane pores that allow leakage of electrolytes.
  4. This drug inhibits DNA and RNA biosynthesis by conversion to 5-fluorouracil by cytosine deaminase.
    Flucytosine
  5. What is the MOA of Flucytosine?
    Inhibits DNA and RNA biosynthesis by conversion to 5-fluorouracil by cytosine deaminase.
  6. These drugs inhibit fungal sterol (ergosterol) synthesis, by inhibiting the cytochrome P-450 enzyme that converts lanosterol to ergosterol.
    • Azoles
    • Fluconazole
    • Ketoconazole
    • Clotrimazole
    • Miconazole
    • Itraconazole
    • Voriconazole
  7. What is the MOA of Azoles- Fluconazole, ketoconazole, clotrimazole, miconazole, itraconazole, voriconazole?
    Inhibit fungal ergosterol synthesis, by inhibiting the cytochrome P-450 enzyme that converts lanosterol to ergosterol.
  8. This drug inhibits the fungal enzyme squalene epoxidase.
    • Inhibits squaline epoxidase
    • Squaline ⇨ Squaline epoxide ⇨ Lanosterol
  9. What is the MOA of Terbinafine?
    • Inhibits squaline epoxidase
    • Squaline ⇨ Squaline epoxide ⇨ Lanosterol
  10. What is the MOA of Echinocandins?
    • Inhibits cell wall synthesis by inhibiting synthesis of β-glucan
    • Echinocandins:
    • Caspofungin, micafungin, anidulafungin
  11. What is the MOA of Caspofungin?
    • Inhibits cell wall synthesis by inhibiting synthesis of β-glucan
    • Echinocandins:
    • Caspofungin, micafungin, anidulafungin
  12. What is the MOA of Anidulafungin?
    • Inhibits cell wall synthesis by inhibiting synthesis of β-glucan
    • Echinocandins:
    • Caspofungin, micafungin, anidulafungin
  13. These drugs inhibits cell wall synthesis by inhibiting synthesis of β-glucan.
    • Echinocandins:
    • Caspofungin, micafungin, anidulafungin
  14. This type of drug works by interfering with microtubule function; disrupts mitosis.
    Griseofulvin
  15. This drug deposits in keratin-containing tissues (e.g., nails).
    Griseofulvin
  16. What is the MOA of Griseofulvin?
    • Interferes with microtubule function, disrupts mitosis.
    • Deposits in keratin-containing tissues (e.g., nails).
  17. This drug is used in the treatment of oral candidiasis.
    Nystatin
  18. This drug is used topically for the treatment of diaper rash caused by Candidia.
    Nystatin
  19. What is the use of Nystatin?
    • Swish and swallow” for oral candidiasis (thrush)
    • Topical for diaper rash or vaginal candidiasis
  20. What is the use of Flucytosine?
    Systemic fungal infections (esp. meningitis caused by Cryptococcus) in combination with amphotericin B.
  21. What are the side effects of Flucytosine?
    Bone marrow suppression
  22. This antifungal medication can cause bone marrow suppression.
    Azoles
  23. This antifungal drug can cause liver dysfunction.
    • Azoles
    • inhibits cytochrome P-450
  24. This antifungal medication can cause gynecomastia.
    • Azoles
    • Testosterone synthesis inhibition (gynecomastia - especially with ketoconazole)
  25. What are the side effects associated with the use of Azoles?
    • Testosterone synthesis inhibition (gynecomastia, esp. with ketoconazole)
    • Liver dysfunction (inhibits cytochrome P-450).

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