Fusion inhibitor T20, binds to gp41 preventing the creation of an entry pore for the capsid of the virus, keeping it out of the cell.
Replaces 3’ OH
block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA, thus preventing HIV from multiplying
– binds a pocket in the
“palm” of reverse transcriptase
preventing RT from properly
grasping the nucleic acids
action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell. Since integration is a vital step in retroviral replication, blocking it can halt further spread of the virus.
prevent virus maturation and thus infectivity
* ritonavir probs
A PI and a p450 inhibitor and may thus influence the function of other drugs.