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The common denominator in the hemoglobinopathies is that all are?
inherited, or genetic defect related to hemoglobin
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hemoglobinopathies can be classified as?
- abnormal hemoglobin globulin structure
- a defect of hemoglobin globulin synthesis
- a combination of defects of both structure and synthesis
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in a hemoglobinopathies a trait is described as?
heterozygous and asymptomatic
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in sickle cell anemia the cause is?
- a change of a single nucleotide ( GAT to GTT)
- a substitution of veline for glutamic acid at the 6th position on the beta chain of the hemoglobin molecule.
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In the sickle cell disease the abnormality is related to?
an abnormal molecular structure of hemoglobin
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one of the most common MONOGENIC diseases of man is ?
sickle cell anemia.
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if a patient with sickle cell anemia is in an acute crisis state, peripheral blood smears may exib
drepanocytes
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what estimated percentage of black Americans are heterozygous for Hd S?
8%
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What factors contribute to the sickling of erythrocytes in sickle cell anemia crisis?
- extremely reduced oxygen
- increased acidity in the blood.
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the most common complained associated with sickle cell anemia is?
Acute pain
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What is the primary risk to thalassemia major patients w ho receive frequent and multiple blood transfusions?
Iron overload
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the peripheral blood smear in silent state patients with alpha-thalassemia typically appears as ?
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Southeast Asia is highest in incidence of?
Hb E Hemoglobinopathy
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Normal adult hemoglobin contains the following components:
Hb A (95% to 98%),
Hb A2 (2% to 3%),
Hb A1(3% to 6%), and
Hb F (<1%).
TRUE
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