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3 ways to use monoclonal antibodies in tumor therapy
- 1) add mAb which binds tumor cell. Phagocytes bind Fc region and kill cell
- 2) couple mAb with a toxin that kills tumor cell
- 3) couple mAb with an enzyme that coverts a prodrug to active drug
adjuvents used in tumor therapy to increase immune response
BCG, muramyl tripeptide
used in tumor treatment. works by activating signaling pathways and increasing MHCI expression
released by TH1 cells. increases macrophage and NK cytotoxicity by increasing MHCI/II expression. can be used in cancer treatment
secreted by macrophages. cytotoxic to tumor cell
three phases of immunosurveillance
elimination, equilibration, and escape
hyper IgM syndrome
T-cells lack CD40L. thus, they can't induce the B-cells to make different Ig's. Result: only IgM made.
reduced T-cell function and some Ig classes are deficent. Due to inability to repair DNA
X-linked. T-cells make ineffective response to antigen.
If you have a problem with your B-cells, infections will mostly be caused by...
bacteria (high grade antigens)
If you have a problem with your T-cells, infections will mostly be caused by...
fungi, virus (low grade)
If you have a problem with your phagocytic cells, infections will mostly be caused by...
bacteria of low virulence, pyogenic organisms
If you have a problem with your complement cells, infections will mostly be caused by...
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