dyslipidemia.txt

Card Set Information

Author:
kmegk22
ID:
300
Filename:
dyslipidemia.txt
Updated:
2009-10-15 13:01:28
Tags:
dyslipidemia
Folders:

Description:
statins and fibrates
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  1. Atorvastatin
    • lipitor
    • hmgcoa reductase inhibitor
    • 10-80mg 1 x day
    • fibrates and niacin --> inc myopathy
    • warfarin, macrolides
    • 3a4 inhib
    • dyspepsia, diarrhea, mypoathy, rhabdomyloys
  2. simvastatin
    • zocor
    • hmgcoa reductase inhib
    • 5-80mg po 1 x day
    • fibrates and niacin --> inc myopathy
    • warfarin, macrolides
    • 3a4 inhib
    • dyspepsia, diarrhea, mypoathy, rhabdomyloys
  3. lovastatin
    • mevacor
    • hmgcoa reductase inhib
    • 10-80mg in 1-2 divided doses
    • fibrates and niacin --> inc myopathy
    • warfarin, macrolides
    • 3a4 inhib
    • dyspepsia, diarrhea, mypoathy, rhabdomyloys
  4. rosuvastatin
    • crestor
    • hmg coa reductase inhib
    • 5-40mg 1 x day
    • fibrates and niacin --> inc myopathy
    • warfarin, macrolides
    • dyspepsia, diarrhea, mypoathy, rhabdomyloys, elevated liver enzymes
  5. pravastatin
    • pravachol
    • hmgcoa reductase inhib
    • 10-80 mg 1 x day
    • fibrates and niacin --> inc myopathy
    • warfarin, macrolides
    • dyspepsia, diarrhea, mypoathy, rhabdomyloys, elevated liver enzymes
  6. ezetimbime
    • zetia
    • cholesterol absroption inhibitor
    • 10mg 1 x day
    • bile acid resins, cyclosporins, fibrates
    • GI upset, diarrhea, fatigue
  7. ezetimibe/simvastain
    • vytorin
    • stain + cholesterol absorption inhibiton
    • 10/10 - 10/80
    • bile acid resins, cyclosprin, fibrates, niacin, warfarin, macrolides, 3a4 inhib
    • GI upset, diarrea, fatigue, dyspepsia, mypopathy, rhabdomyloys, elevated liver enzymes
  8. fenofibrate
    • tricor
    • fibrate: activation of peroxisome PPAR that activate lipase and dec apoC III leading to clearance of TG
    • 48-145 mg po daily
    • statins, niacin, warfarin, rosiglitazone, glyburide,
    • dyspepsia, myopathy, gallstones, elevated liver enzymes
  9. gemfibrozil
    • lopid
    • fibrate: activation of PPAR that activate lipase and dec apo c II leading to clearance of tg
    • 600mg po bid
    • statins, niacin, warfarin, rosiglitazone, glyburide,
    • dyspepsia, myopathy, gallstones, elevated liver enzymes

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