Therapeutics - Chemo 1

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kyleannkelsey
ID:
300613
Filename:
Therapeutics - Chemo 1
Updated:
2015-04-12 21:31:58
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Therapeutics Chemo
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Therapeutics - Chemo
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Therapeutics - Chemo
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  1. What are the Common uses for 5FU?
    • Colorectal
    • Breast
    • H &N
    • Pancreatic
    • Gastric
  2. What are the SE for 5FU?
    • Stomatitis (HT, DLT)
    • Diarrhea (HT, DLT)
    • H & F syndrome
  3. What special information should you know about 5FU?
    • Radiosensitizer
    • Leucovorin enhances activity and toxicity
    • DDI with Warfarin
  4. What are the Common uses for Capecetibine?
    • Colorectal
    • Breast
  5. What are the SE for Capecetibine?
    • Diarrhea
    • Stomatitis
    • H & F syndrome (HT, DLT)
  6. What special information should you know about Capecetibine?
    • Prodrug of 5FU
    • Oral tablet
    • Hand and Foot Syndrome = desquamation, pain, bleeding, ulceration
    • DDI w/ warfarin
  7. What are the Common uses for Cytarbine?
    • AML
    • CML
    • Relapsed NHL
    • HL
  8. What are the SE for Cytarbine?
    • Std dose: Myelosupression
    • >1gm/m2: Cerebellar syndrome (DL, HT), conjunctivitis
  9. What special information should you know about Cytarbine?
    Neuro checks before each dose for Cerebellar syndrome (slurred speech, ataxia, confusion)
  10. What are the Common uses for Azacitidine?
    • MDS
    • CML
  11. What are the SE for Azacitidine?
    • Myelosupression
    • Febrile neutropenia
    • Fever
  12. What special information should you know about Azacitidine?
    • No live vaccines
    • <5% cardiac problems (A fib and CHF)
    • SQ injection
  13. What are the Common uses for Decitabine?
    CDL, MDS and AML
  14. What are the SE for Decitabine?
    • Hyperglycemia (HT)
    • Edema
    • Pneumonia
    • Decreased K and Mg
    • Myelosupression
  15. What special information should you know about Decitabine?
    • No live vaccines
    • <5% cardiac toxicity (A fib or CHF)
  16. What are the Common uses for Gemcitabine?
    • NSCLC and Metastatic Breast cancer
    • Increased QOL – DOC – Pancreatic cancer
  17. What are the Common uses for Methotrexate?
    All, NHL, breast cancer, Osteosarcoma
  18. What are the SE for Methotrexate?
    • LD: Hepatotoxicity and pulmonary toxicity
    • HD: Myelosupression, Mucositis and Diarrhea (HT and DL), Nephrotoxicity (HT)
  19. What special information should you know about Methotrexate?
    • DDI with Bactrim and NSAIDs
    • Hyrdrate w/ Bicarb, keep urine >7 pH until drug levels are safe
    • Rescue: give leucovorin 24-36hr post dose with doses >100 mg/m2, use until levels drop below 0.05 or 0.02
  20. What are the Common uses for Pemetrexed?
    NHL and Peripheral T-cell lymphoma
  21. What are the SE for Pemetrexed?
    Myelosupresssion, Edema, Mucositis and Diarrhea
  22. What special information should you know about Pemetrexed?
    • DDI with Bactrim and NSAIDs
    • Rescue: Folic Acid 1 mg/day (10 days before and 30 days after)
    • B12 100 mcg IM before and Q9wk
    • Dexamethasone 4 mg BID x3 days, starting before therapy
  23. What are the Anti-microtubule agents?
    • Taxanes: -taxel
    • Vinca Alkaloids: Vin-ine
    • Estramustine
  24. What are the Common uses for Paclitaxol?
    • Breast
    • Ovarian
    • Gastric
    • NSCLC/SCLC
    • H & N
  25. What are the SE for Paclitaxel?
    • Peripheral neuropathy (DLT)
    • Complete alopecia (HT)
    • Hypersensitivity
    • Myalgias
  26. What special information should you know about Paclitaxel?
    • Premedicate with Dexa, Benadryl and H2 antagonist
    • NO PVC
  27. What are the Common uses for Paclitaxel NAB?
    • Breast
    • H & N
    • NSCLC
  28. What are the SE for Paclitaxel NAB?
    • Myelosupresion
    • PN
  29. What special information should you know about Paclitaxel NAB?
    • Not dose equivalent to Paclitaxel
    • No pre-meds
  30. What are the Common uses for Docetaxel?
    • Breast
    • NSCLC
    • H & N
    • Prostate
    • Gastric
  31. What are the SE for Docetaxel?
    • Edema (HT)
    • PN
    • Complete alopecia
  32. What special information should you know about Docetaxel?
    • Dexamethasone 8 mg BID x 3 days
    • NO PVC
  33. What are the Common uses for Cabazitaxel?
    Hormone refractory metastatic prostate cancer
  34. What are the SE for Cabazitaxel?
    • Neutropenia
    • N/V
    • Diarrhea
    • Hypersensitivity
  35. What special information should you know about Cabazitaxel?
    • CYP3A4 metabolized
    • No PVC
    • Pre-medicate with Dexa, Benadryl and H2 antagonist
  36. What are the Common uses for Ixabepilone?
    Breast and Prostate cancer
  37. What are the SE for Ixabepilone?
    • PN (DLT)
    • Hypersensitivity
    • Myalgias
  38. What special information should you know about Ixabepilone?
    • CYP3A4 metabolized
    • No PVC
    • May cause cardiac dysfunction
    • Pre-medicate with Benadryl and H2 antagonist (Dexa if hypersensitivity occurs)
    • CI in hepatotoxicity

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